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The study identified 21 multimegabase polymorphic inversions ranging in size from 5 to 55 Mbp. Inversions were more abundant in African than in non-African strains, 15 versus 3 inversions, with the highest number observed in West Africa. All inversions were grouped into two geographic clusters of African or non-African origin, suggesting their association with A. aegypti subspecies. Inversions were unevenly distributed along chromosomal arms, with the highest number found in the 1q and 3p arms homologous to the inversion-rich 2R chromosomal arm in the malaria vector Anopheles gambiae. Direct comparison of inversions between A. aegypti and An. gambiae revealed significant overlap in their genomic locations. This finding may explain the parallel evolution of the two species under similar environmental conditions. Some of the inversions colocalized with chemoreceptor genes and quantitative trait loci associated with pathogen infection, suggesting their potential role in host preference and disease transmission. Our study revealed the large pool of structural variations in the A. aegypti genome and provides the foundation for future studies of their impact on the biology of this important arboviral vector.<\/jats:p>","DOI":"10.1093\/gbe\/evaf118","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T07:45:32Z","timestamp":1749282332000},"source":"Crossref","is-referenced-by-count":10,"title":["Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector <i>Aedes aegypti<\/i>"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8468-7457","authenticated-orcid":false,"given":"Jiangtao","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Entomology, Virginia Polytechnic Institute and State University , Blacksburg, VA ,","place":["USA"]},{"name":"Fralin Life Science Institute, Virginia Polytechnic Institute and State University , Blacksburg, VA 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