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Here, we identify segmental duplications from long-read-sequenced genomes of 117 vertebrates and one starfish, generating the largest multispecies dataset of its kind. We find that vertebrate genomes show a higher propensity for tandem duplications than for interspersed duplications. However, when focusing only on subtelomeric regions, avian and mammalian genomes show the opposite propensity toward interspersed duplications. We also observe that, across vertebrates, tandem duplications tend to be larger than interspersed duplications. Next, we construct a segmental-duplication network for each species and use network-derived metrics to quantify the duplication landscape for that species. We then compute interspecies distances for each metric and find that these distances show at most weak correlations with phylogenetic distance, indicating that segmental-duplication landscapes evolve rapidly. Functional-enrichment analysis of hyperduplicated genes reveals a strong enrichment in platypus for pheromone response, driven by the expansion of the vomeronasal pheromone receptor V1R gene family. Overall, our results uncover the general properties of vertebrate segmental duplications, demonstrate the lability of segmental-duplication landscapes, and highlight the utility of network-based approaches for studying genome evolution.<\/jats:p>","DOI":"10.1093\/gbe\/evag043","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:40:11Z","timestamp":1772109611000},"source":"Crossref","is-referenced-by-count":3,"title":["Genomes From 117 Vertebrate Species Reveal Rapidly Evolving Segmental-Duplication Landscapes"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-6495","authenticated-orcid":false,"given":"Alber","family":"Aqil","sequence":"first","affiliation":[{"name":"Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, MI ,","place":["USA"]},{"name":"Department of Biological Sciences, State University of New York at Buffalo , Buffalo, NY ,","place":["USA"]},{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, NJ ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiful","family":"Islam","sequence":"additional","affiliation":[{"name":"Institute for Artificial Intelligence and Data Science, State University of New York at Buffalo , Buffalo, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-0172","authenticated-orcid":false,"given":"Faraz","family":"Hach","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre , Vancouver, British Columbia ,","place":["Canada"]},{"name":"Department of Urologic Sciences, University of British Columbia , Vancouver, British Columbia ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-7937","authenticated-orcid":false,"given":"Ibrahim","family":"Numanagi\u0107","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Victoria , Victoria, BC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-801X","authenticated-orcid":false,"given":"Naoki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Gilbert S. 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