{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:05:52Z","timestamp":1785888352410,"version":"3.56.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Certain mutations in the unc-105 II gene of the nematode Caenorhabditis elegans have dominant effects on morphology and behavior: animals become small, severely hypercontracted and paralyzed. These unc-105 mutants revert both spontaneously and with mutagens at high frequencies to a wild-type phenotype. Most of the reversion events are intragenic, apparently because the null (loss-of-function) phenotype of unc-105 is wild type. One revertant defined an extragenic suppressor locus, sup-20 X. Such suppressor alleles of sup-20 are rare, and the apparent null phenotype of sup-20 is embryonic lethality. By constructing animals genetically mosaic for sup-20, we have shown that the primary effect of sup-20 is in muscle cells. In addition to mutations in sup-20, other mutations causing muscle defects, such as unc-54 and unc-22 mutations, suppress the hypercontracted phenotype of unc-105. The ease of identifying nonhypercontracted revertants of unc-105 mutants greatly facilitates the isolation of new mutants defective in muscle structure and function.<\/jats:p>","DOI":"10.1093\/genetics\/113.4.853","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T07:17:03Z","timestamp":1609917423000},"page":"853-867","source":"Crossref","is-referenced-by-count":51,"title":["<i>C. ELEGANS unc-105<\/i> MUTATIONS AFFECT MUSCLE AND ARE SUPPRESSED BY OTHER MUTATIONS THAT AFFECT MUSCLE"],"prefix":"10.1093","volume":"113","author":[{"given":"Eun-Chung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Robert","family":"Horvitz","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1986,8,1]]},"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/113\/4\/853\/34450959\/genetics0853.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/113\/4\/853\/34450959\/genetics0853.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:22:22Z","timestamp":1619115742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/113\/4\/853\/5997022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/113.4.853","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1986,8,1]]},"published":{"date-parts":[[1986,8,1]]}}}