{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T12:50:58Z","timestamp":1648903858764},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Recessive lethal mutations have been isolated and used to maintain n + 1 aneuploid strains of Dictyostelium discoideum carrying a duplication of part or all of linkage group VII. The recessive lethal mutations, relA351 and relB352, arose spontaneously in diploids; no mutagenic treatment was used in the isolation of these mutations. The probable gene order on linkage group VII is: centromere, relB, couA, bsgB, cobA, relA . Maintenance of aneuploids disomic for linkage group VII was made possible by complementation of a rel mutation on each linkage group VII homologue by the corresponding wild-type allele on the other linkage group VII homologue. The duplication-bearing disomic strains were slow-growing and produced faster-growing sectors on the colony edge. Haploid sectors probably arise by a combination of mitotic recombination and subsequent loss of one homologue, diploid sectors may be formed by chromosome doubling to 2n + 2, followed by chromosome loss to return to 2n, and aneuploid sectors may arise by deletion or new mutation.<\/jats:p>","DOI":"10.1093\/genetics\/115.1.101","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T09:33:37Z","timestamp":1609925617000},"page":"101-106","source":"Crossref","is-referenced-by-count":1,"title":["Recessive Lethal Mutations and the Maintenance of Duplication-Bearing Strains of <i>Dictyostelium discoideum<\/i>"],"prefix":"10.1093","volume":"115","author":[{"given":"Dennis L","family":"Welker","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biochemie, 8033 Martinsried bei M\u00fcnchen, Federal Republic of Germany, Department of Biology, Utah State University, Logan, Utah 84322-5500"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith L","family":"Williams","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Biochemie, 8033 Martinsried bei M\u00fcnchen, Federal Republic of Germany, School of Biological Sciences, Macquarie University, North Ryde, N.S.W., Australia 2113"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,1,1]]},"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/115\/1\/101\/34452802\/genetics0101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/115\/1\/101\/34452802\/genetics0101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:26:38Z","timestamp":1619115998000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/115\/1\/101\/5997336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/115.1.101","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1987,1,1]]},"published":{"date-parts":[[1987,1,1]]}}}