{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:28:00Z","timestamp":1760956080679},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The courtship song of a Drosophila melanogaster male consists of tone pulses interspersed with humming sounds. An X chromosomal mutation, cacophony (cac), causes the production of polycyclic pulses readily distinguishable from those in wild type, which are mono- or bicyclic. Yet, courtship hums and flight wing beats are normal in this mutant, suggesting a specific role of the cac gene in the neural program underlying one particular feature of the fly's wing vibrations. A precise cytogenetic localization of cac is presented; this was obtained by uncovering the song abnormality with deletions that are missing all or the distal part of region 11A; the flies tested were diplo-X adults that had been turned into males by the transformer mutation. Duplications including distal 11A covered cac. The possibility of behavioral specificity for cac's effects was examined by screening a variety of sexual and nonsexual behaviors; these experiments included tests of flies in which the mutation was uncovered by a small deletion. We conclude that cac causes only a limited array of well-defined defects: longer and louder tone pulses in the song and depressed locomotor activity. Further complementation tests involving cac and other closely linked genetic variants-the night-blind-A (nbA) visual mutation, l(1) L13 lethal mutations, and a series of X chromosomal breakpoints-suggested complex interactions among these factors: the breakpoints uncover all three types of mutations; cac and nbA appear to be alleles of l(1)L13, whereas the two behavioral mutations complement each other<\/jats:p>","DOI":"10.1093\/genetics\/115.3.461","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T08:48:16Z","timestamp":1609922896000},"page":"461-475","source":"Crossref","is-referenced-by-count":63,"title":["Behavioral and Cytogenetic Analysis of the <i>cacophony<\/i> Courtship Song Mutant and Interacting Genetic Variants in <i>Drosophila melanogaster<\/i>"],"prefix":"10.1093","volume":"115","author":[{"given":"Shankar J","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Department of Biology, Brandeis University, Waltham, Massachusetts 02254"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biology, Brandeis University, Waltham, Massachusetts 02254"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,3,1]]},"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/115\/3\/461\/34452445\/genetics0461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/115\/3\/461\/34452445\/genetics0461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:25:15Z","timestamp":1619115915000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/115\/3\/461\/5997261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/115.3.461","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1987,3,1]]},"published":{"date-parts":[[1987,3,1]]}}}