{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:34:49Z","timestamp":1760369689679},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genetic screens in zebrafish have provided mutations in hundreds of genes with essential functions in the developing embryo. To investigate the possible uses of chromosomal rearrangements in the analysis of these mutations, we genetically characterized three gamma-ray induced alleles of cyclops (cyc), a gene required for development of midline structures. We show that cyc maps near one end of Linkage Group 12 (LG 12) and that this region is involved in a reciprocal translocation with LG 2 in one gamma-ray induced mutation, cyc b213. The translocated segments together cover approximately 5% of the genetic map, and we show that this rearrangement is useful for mapping cloned genes that reside in the affected chromosomal regions. The other two alleles, cycb16 and cycb229, have deletions in the distal region of LG 12. Interestingly, both of these mutations suppress recombination between genetic markers in LG 12, including markers at a distance from the deletion. This observation raises the possibility that these deletions affect a site required for meiotic recombination on the LG 12 chromosome. The cycb16 and cycb229 mutations may be useful for balancing other lethal mutations located in the distal region of LG 12. These results show that chromosomal rearrangements can provide useful resources for mapping and genetic analyses in zebrafish.<\/jats:p>","DOI":"10.1093\/genetics\/148.1.373","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T23:03:49Z","timestamp":1613171029000},"page":"373-380","source":"Crossref","is-referenced-by-count":31,"title":["Genetic Analysis of Chromosomal Rearrangements in the cyclops Region of the Zebrafish Genome"],"prefix":"10.1093","volume":"148","author":[{"given":"William S","family":"Talbot","sequence":"first","affiliation":[{"name":"Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S","family":"Egan","sequence":"additional","affiliation":[{"name":"Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Gates","sequence":"additional","affiliation":[{"name":"Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charline","family":"Walker","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan C F","family":"Neuhauss","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B","family":"Kimmel","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Postlethwait","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2021042713175698400_R1","volume-title":"Drosophila: A Laboratory Handbook","author":"Ashburner","year":"1989"},{"key":"2021042713175698400_R2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0168-9525(96)30094-2","article-title":"Combining mutagenesis and genomics in the mouse\u2014closing the phenotype gap","volume":"12","author":"Brown","year":"1996","journal-title":"Trends 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