{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:27:54Z","timestamp":1762900074492},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex\u2013linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA\/2J \u00d7 B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.<\/jats:p>","DOI":"10.1093\/genetics\/148.4.1941","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T23:48:59Z","timestamp":1613173739000},"page":"1941-1949","source":"Crossref","is-referenced-by-count":21,"title":["Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus\u2013Induced Demyelination in the Mouse"],"prefix":"10.1093","volume":"148","author":[{"given":"J-F","family":"Bureau","sequence":"first","affiliation":[{"name":"Unite des Virus Lents, Centre National de la Recherche Scientifique ERS 572, Institut Pasteur, Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Drescher","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L R","family":"Pease","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Vikoren","sequence":"additional","affiliation":[{"name":"Unite des Virus Lents, Centre National de la Recherche Scientifique ERS 572, Institut Pasteur, Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Delcroix","sequence":"additional","affiliation":[{"name":"Unite des Virus Lents, Centre National de la Recherche Scientifique ERS 572, Institut Pasteur, Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zoecklein","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Brahic","sequence":"additional","affiliation":[{"name":"Unite des Virus Lents, Centre National de la Recherche Scientifique ERS 572, Institut Pasteur, Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"2022010308575385100_R1","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1007\/s003359900326","article-title":"Mouse chromosome 14","volume":"7","author":"Abbadi","year":"1997","journal-title":"Mamm. Gen."},{"key":"2022010308575385100_R2","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/jvi.68.6.4049-4052.1994","article-title":"FVB mice transgenic mice for the H-2Db gene become resistant to persistent infection by Theiler's virus","volume":"68","author":"Azoulay","year":"1994","journal-title":"J. Virol."},{"key":"2022010308575385100_R3","first-page":"65","volume-title":"Zmap-A QTL Cartographer","author":"Basten"},{"key":"2022010308575385100_R4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0993-87","article-title":"Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system","volume":"5","author":"Bureau","year":"1993","journal-title":"Nature Genet."},{"key":"2022010308575385100_R5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics"},{"key":"2022010308575385100_R6","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.4049\/jimmunol.135.2.1408","article-title":"Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity","volume":"135","author":"Clatch","year":"1985","journal-title":"J. Immunol."},{"key":"2022010308575385100_R7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/BF00354297","article-title":"An anchored molecular map of mouse chromosome 6 with an analysis of interference","volume":"6","author":"Davies","year":"1995","journal-title":"Mamm. 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Neuroimmunol."},{"key":"2022010308575385100_R12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/ng0896-472","article-title":"A full genome screen in multiple sclerosis","volume":"13","author":"Ebers","year":"1996","journal-title":"Nature Genet."},{"key":"2022010308575385100_R13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00352339","article-title":"Additional microsatellite markers for mouse genome mapping","volume":"1","author":"Hearne","year":"1991","journal-title":"Mamm. 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Differences between susceptible SJL\/J and resistant BALB\/c strains map near the T cell beta chain constant genes on chromosome 6","volume":"138","author":"Melvold","year":"1986","journal-title":"J. Immunol."},{"key":"2022010308575385100_R20","first-page":"735","article-title":"H-2 genes in TMEV-induced demyelination, a model for multiple sclerosis","volume-title":"Major Histocompatibility Genes and Their Role in Immune Function","author":"Melvold","year":"1987"},{"key":"2022010308575385100_R21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/jvi.64.2.686-690.1990","article-title":"Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease","volume":"64","author":"Melvold","year":"1990","journal-title":"J. Virol."},{"key":"2022010308575385100_R22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00352333","article-title":"PCR-analyzedmicrosatellites: data concerning laboratory and wild-derived mouse inbred strains","volume":"1","author":"Montagutelli","year":"1991","journal-title":"Mamm. Gen."},{"key":"2022010308575385100_R23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ng0896-469","article-title":"A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex","volume":"13","author":"Multiple Sclerosis Study Group","year":"1996","journal-title":"Nature Genet."},{"key":"2022010308575385100_R24","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1099\/0022-1317-71-9-2123","article-title":"Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL\/J mice","volume":"71","author":"Patick","year":"1990","journal-title":"J. Gen. Virol."},{"key":"2022010308575385100_R25","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1128\/jvi.64.11.5570-5576.1990","article-title":"Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice","volume":"64","author":"Patick","year":"1990","journal-title":"J. Virol."},{"key":"2022010308575385100_R26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1179\/his.1989.12.1.35","article-title":"Eichrome stain for myelin on osmicated tissue embedded in glycol methacrylate plastic","volume":"12","author":"Pierce","year":"1989","journal-title":"J. Histotech."},{"key":"2022010308575385100_R27","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.4049\/jimmunol.135.3.2145","article-title":"Demyelination induced by Theiler's virus: influence of the H-2 haplotype","volume":"135","author":"Rodriguez","year":"1985","journal-title":"J. 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Neurol."},{"key":"2022010308575385100_R30","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1212\/WNL.36.7.964","article-title":"Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immuneresponse gene products (Ia antigens)","volume":"36","author":"Rodriguez","year":"1986","journal-title":"Neurology"},{"key":"2022010308575385100_R31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1084\/jem.163.3.620","article-title":"Susceptibility to Theiler's virus\u2013induced demyelination. Mapping of the gene within the H-2D region","volume":"163","author":"Rodriguez","year":"1986","journal-title":"J. Exp. Med."},{"key":"2022010308575385100_R32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.4049\/jimmunol.148.3.921","article-title":"Role of T cell receptor V\u03b2 genes in Theiler's virus-induced demyelination in mice","volume":"148","author":"Rodriguez","year":"1992","journal-title":"J. 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