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The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine. The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye. Analysis ofthe various courtship and visual phenotypes associated with this array ofcac mutants demonstrates that Dmca1A calcium channels mediate multiple, separable biological functions; these correlate in part with transcript diversity generated via alternative splicing.<\/jats:p>","DOI":"10.1093\/genetics\/149.3.1407","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T01:47:08Z","timestamp":1619574428000},"page":"1407-1426","source":"Crossref","is-referenced-by-count":77,"title":["Courtship and Visual Defects of cacophony Mutants Reveal Functional Complexity of a Calcium-Channel \u03b11 Subunit in Drosophila"],"prefix":"10.1093","volume":"149","author":[{"given":"Lee A","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Villella","sequence":"additional","affiliation":[{"name":"Department of Biology, Brandeis University, Waltham, Massachusetts 02254"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biology, Brandeis University, Waltham, Massachusetts 02254"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2022010309475186800_R1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.275.5303.1119","article-title":"Calmodulin regulation of calcium stores in phototransduction of Drosophila","volume":"275","author":"Arnon","year":"1997","journal-title":"Science"},{"key":"2022010309475186800_R2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1857984","article-title":"A component of calcium-activated potassium channels encoded by the Drosophila slo locus","volume":"253","author":"Atkinson","year":"1991","journal-title":"Science"},{"key":"2022010309475186800_R3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/384078a0","article-title":"K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current","volume":"384","author":"Barhanin","year":"1996","journal-title":"Nature"},{"key":"2022010309475186800_R4","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1073\/pnas.58.3.1112","article-title":"Behavioral mutants of Drosophila isolated by countercurrent distribution","volume":"58","author":"Benzer","year":"1967","journal-title":"Proc. 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