{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:29:26Z","timestamp":1789907366113,"version":"4.0.1"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genomic imprinting is a phenomenon in which the expression of a gene or chromosomal region depends on the sex of the individual transmitting it. The term imprinting was first coined to describe parent-specific chromosome behavior in the dipteran insect Sciara and has since been described in many organisms, including other insects, plants, fish, and mammals. In this article we describe a mini-X chromosome in Drosophila melanogaster that shows genomic imprinting of at least three closely linked genes. The imprinting of these genes is observed as mosaic silencing when the genes are transmitted by the male parent, in contrast to essentially wild-type expression when the same genes are maternally transmitted. We show that the imprint is due to the sex of the parent rather than to a conventional maternal effect, differential mitotic instability of the mini-X chromosome, or an allele-specific effect. Finally, we have examined the effects of classical modifiers of position-effect variegation on the maintenance and the establishment of the imprint. Factors that modify position-effect variegation alter the somatic expression but not the establishment of the imprint. This suggests that chromatin structure is important in maintenance of the imprint, but a separate mechanism may be responsible for its initiation.<\/jats:p>","DOI":"10.1093\/genetics\/151.4.1503","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:03:36Z","timestamp":1619579016000},"page":"1503-1516","source":"Crossref","is-referenced-by-count":49,"title":["Genomic Imprinting and Position-Effect Variegation in Drosophila melanogaster"],"prefix":"10.1093","volume":"151","author":[{"given":"Vett K","family":"Lloyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don A","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Grigliatti","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2022010314430643600_R1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/333852a0","article-title":"Transgenes as probes for active chromosomal domains in mouse development","volume":"333","author":"Allen","year":"1988","journal-title":"Nature"},{"key":"2022010314430643600_R2","first-page":"81","article-title":"The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preimplantation development","volume-title":"Genomic Imprinting (Development, supplement 1990)","author":"Babinet","year":"1990"},{"key":"2022010314430643600_R3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/genetics\/38.4.328","article-title":"V-type position effects of a gene in Drosophila virilis normally located in heterochromatin","volume":"38","author":"Baker","year":"1953","journal-title":"Genetics"},{"key":"2022010314430643600_R4","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1101\/gad.7.9.1663","article-title":"Epigenetic mechanisms underlying the imprinting of the mouse H19 gene","volume":"7","author":"Bartolomei","year":"1993","journal-title":"Genes Dev."},{"key":"2022010314430643600_R5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/genetics\/96.1.165","article-title":"Male-specific lethal mutations of Drosophila melanogaster","volume":"96","author":"Belote","year":"1980","journal-title":"Genetics"},{"key":"2022010314430643600_R6","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/nar\/8.7.1485","article-title":"Variable patterns of total DNA and rDNA methylation in animals","volume":"8","author":"Bird","year":"1980","journal-title":"Nucleic Acids Res."},{"key":"2022010314430643600_R7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1469-1809.1974.tb01833.x","article-title":"A sex related factor in the inheritance of Huntington's chorea","volume":"37","author":"Bird","year":"1974","journal-title":"Ann. 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