{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:57:22Z","timestamp":1762102642280},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A study of DNA polymorphism and divergence was conducted for the cytosolic phosphoglucose isomerase (PGI:E.C.5.3.1.9) gene of five species of the mustard genus Leavenworthia: Leavenworthia stylosa, L. alabamica, L. crassa, L. uniflora, and L. torulosa. Sequences of an internal 2.3-kb PgiC gene region spanning exons 6\u201316 were obtained from 14 L. stylosa plants from two natural populations and from one to several plants for each of the other species. The level of nucleotide polymorphism in L. stylosa PgiC gene was quite high (\u03c0 = 0.051, \u03b8 = 0.052). Although recombination is estimated to be high in this locus, extensive haplotype structure was observed for the entire 2.3-kb region. The L. stylosa sequences fall into at least two groups, distinguished by the presence of several indels and nucleotide substitutions, and one of the three charge change nucleotide replacements within the region sequenced correlates with the haplotypes. The differences between the haplotypes are older than between the species, and the haplotypes are still segregating in at least two of five species studied. There is no evidence of recent or ancient population subdivision that could maintain distinct haplotypes. The age of the haplotypes and the results of Kelly's ZnS and Wall's B and Q tests with recombination suggest that the haplotypes are maintained due to balancing selection at or near this locus.<\/jats:p>","DOI":"10.1093\/genetics\/153.3.1423","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T05:10:41Z","timestamp":1619586641000},"page":"1423-1434","source":"Crossref","is-referenced-by-count":77,"title":["DNA Polymorphism, Haplotype Structure and Balancing Selection in the Leavenworthia PgiC Locus"],"prefix":"10.1093","volume":"153","author":[{"given":"Dmitry A","family":"Filatov","sequence":"first","affiliation":[{"name":"Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Charlesworth","sequence":"additional","affiliation":[{"name":"Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"2022010403532141800_R1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/genetics\/134.4.1289","article-title":"The effect of deleterious mutations on neutral molecular variation","volume":"134","author":"Charlesworth","year":"1993","journal-title":"Genetics"},{"key":"2022010403532141800_R2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.hdy.6884000","article-title":"Flowering plant self-incompatibility: the molecular population genetics of Brassica S-loci","volume":"81","author":"Charlesworth","year":"1998","journal-title":"Heredity"},{"key":"2022010403532141800_R3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2540.1998.00415.x","article-title":"Allozyme diversity in Leavenworthia populations with different inbreeding levels","volume":"81","author":"Charlesworth","year":"1998","journal-title":"Heredity"},{"key":"2022010403532141800_R4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/oxfordjournals.molbev.a025955","article-title":"The evolution of the alcohol dehydrogenase gene family in plants of the genus Leavenworthia (Brassicaceae): loss of introns, and an intronless gene","volume":"15","author":"Charlesworth","year":"1998","journal-title":"Mol. 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