{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:36:22Z","timestamp":1791200182033,"version":"4.2.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It has been shown previously that abnormal placental growth, i.e., hyper- and hypoplasia, occurs in crosses and backcrosses between different mouse (Mus) species. A locus that contributes to this abnormal development has been mapped to the X chromosome. Unexpectedly, an influence of fetal sex on placental development has been observed, in that placentas attached to male fetuses tended to exhibit a more pronounced phenotype than placentas attached to females. Here, we have analyzed this sex dependence in more detail. Our results show that differences between male and female placental weights are characteristic of interspecific matings and are not observed in intraspecific Mus musculus matings. The effect is retained in congenic lines that contain differing lengths of M. spretus-derived X chromosome. Expression of the X-linked gene Pgk1 from the maternal allele only and lack of overall activity of two paternally inherited X-linked transgenes indicate that reactivation or lack of inactivation of the paternal X chromosome in trophoblasts of interspecific hybrids is not a frequent occurrence. Thus, the difference between male and female placentas seems not to be caused by faulty preferential X-inactivation. Therefore, these data suggest that the sex difference of placental weights in interspecific hybrids is caused by interactions with the Y chromosome.<\/jats:p>","DOI":"10.1093\/genetics\/157.1.341","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:48:37Z","timestamp":1619581717000},"page":"341-348","source":"Crossref","is-referenced-by-count":27,"title":["Genetic and Developmental Analysis of X-Inactivation in Interspecific Hybrid Mice Suggests a Role for the Y Chromosome in Placental Dysplasia"],"prefix":"10.1093","volume":"157","author":[{"given":"Myriam","family":"Hemberger","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Genetik, 14195 Berlin, Germany"},{"name":"Health Sciences Centre, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haymo","family":"Kurz","sequence":"additional","affiliation":[{"name":"Anatomisches Institut II, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Orth","sequence":"additional","affiliation":[{"name":"Laboratoire G\u00e9nome et Populations, Universit\u00e9 de Montpellier, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Otto","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Genetik, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"L\u00fcttges","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Genetik, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Elliott","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute, Buffalo, New York 14263"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Nagy","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Toronto M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Seng","family":"Tan","sequence":"additional","affiliation":[{"name":"Howard Florey Institute, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tam","sequence":"additional","affiliation":[{"name":"Children\u2019s Medical Research Institute, University of Sydney, Wentworthville, New South Wales 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Zechner","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Genetik, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinald H","family":"Fundele","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Genetik, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"issue":"Suppl.","key":"2022010422133534600_R1","first-page":"405","article-title":"The influence of fetal genotype upon endometrial cup development and PMSG and progestagen production in equids","volume":"23","author":"Allen","year":"1975","journal-title":"J. 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