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By sequence analysis, we find that the Cb-GLP-1 and Cr-GLP-1 proteins have retained the same motif architecture as Ce-GLP-1, including number of domains. In addition, two regions (CC-linker and regions flanking the ANK repeats) are as highly conserved as regions previously recognized as essential for signaling (e.g., ANK repeats). Phylogenetic analysis of glp-1 sequences suggests a C. briggsae\/C. remanei clade with C. elegans as a sister taxon. Using RNAi to test biological functions, we find that Ce-glp-1, Cb-glp-1, and Cr-glp-1 are all required for proliferation of germline stem cells and for specifying blastomere fates in the embryo. In addition, certain biological roles of Cb-glp-1, e.g., in the vulva, have diverged from those of Ce-glp-1 and Cr-glp-1, suggesting a change in either regulation or function of the Cb-glp-1 gene during evolution. Finally, the regulation of glp-1 mRNA, previously analyzed for Ce-glp-1, is conserved in Cb-glp-1, and we identify conserved 3\u2032 UTR sequences that may serve as regulatory elements.<\/jats:p>","DOI":"10.1093\/genetics\/157.2.639","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T05:23:44Z","timestamp":1618291424000},"page":"639-654","source":"Crossref","is-referenced-by-count":47,"title":["Conservation of <i>glp-1<\/i> Regulation and Function in Nematodes"],"prefix":"10.1093","volume":"157","author":[{"given":"David","family":"Rudel","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kimble","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706"},{"name":"Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706"},{"name":"Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin 53706"},{"name":"Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,2,1]]},"reference":[{"key":"2022010422334161200_R1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(00)80909-5","article-title":"The yin and yang of evo\/devo [meeting review]","volume":"92","author":"Akam","year":"1998","journal-title":"Cell"},{"key":"2022010422334161200_R2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.7716513","article-title":"Notch signaling","volume":"268","author":"Artavanis-Tsakonas","year":"1995","journal-title":"Science"},{"key":"2022010422334161200_R3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"2022010422334161200_R4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(87)90128-0","article-title":"glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans","volume":"51","author":"Austin","year":"1987","journal-title":"Cell"},{"key":"2022010422334161200_R5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1139\/z97-051","article-title":"The buccal capsule of Aduncospiculum halicti (Namata: Diplogasterina): an ultrastructural and molecular phylogenetic study","volume":"75","author":"Baldwin","year":"1997","journal-title":"Can. 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