{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:54:57Z","timestamp":1750812897228},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The meiotic properties of paracentric inversion heterozygotes have been well studied in insects and plants, but not in mammalian species. In essence, a single meiotic recombination event within the inverted region results in the formation of a dicentric chromatid, which usually breaks or is stretched between the two daughter nuclei during the first meiotic anaphase. Here, we provide evidence that this is not the predominant mode of exchange resolution in female mice. In sharp contrast to previous observations in other organisms, we find that attempts to segregate the dicentric chromatid frequently result not in breakage, stretching, or loss, but instead in precocious separation of the sister centromeres of at least one homolog. This often further results in intact segregation of the dicentric into one of the meiotic products, where it can persist into the first few embryonic divisions. These novel observations point to an unusual mechanism for the processing of dicentric chromosomes in mammalian oogenesis. Furthermore, this mechanism is rare or nonexistent in mammalian spermatogenesis. Thus, our results provide additional evidence of sexual dimorphism in mammalian meiotic chromosome behavior; in \u201cstressful\u201d situations, meiotic sister chromatid cohesion is apparently handled differently in males than in females.<\/jats:p>","DOI":"10.1093\/genetics\/162.3.1367","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T05:21:20Z","timestamp":1619155280000},"page":"1367-1379","source":"Crossref","is-referenced-by-count":22,"title":["Sex-Specific Differences in Meiotic Chromosome Segregation Revealed by Dicentric Bridge Resolution in Mice"],"prefix":"10.1093","volume":"162","author":[{"given":"Kara E","family":"Koehler","sequence":"first","affiliation":[{"name":"Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise A","family":"Millie","sequence":"additional","affiliation":[{"name":"Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P","family":"Cherry","sequence":"additional","affiliation":[{"name":"Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S","family":"Burgoyne","sequence":"additional","affiliation":[{"name":"Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward P","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry J","family":"Hassold","sequence":"additional","affiliation":[{"name":"Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2022010518015071500_R1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/hmg\/10.9.963","article-title":"Analysis of a malsegregating mouse Y chromosome: evidence that the earliest cleavage divisions of the mammalian embryo are non-disjunction-prone","volume":"10","author":"Bean","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"2022010518015071500_R2","first-page":"1452","article-title":"Chromosomal variants","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Beechey","year":"1996","edition":"Ed. 3"},{"key":"2022010518015071500_R3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF01731725","article-title":"Synapsis in single and double heterozygotes for partially overlapping inversions in the chromosome 1 of the house mouse","volume":"99","author":"Borodin","year":"1990","journal-title":"Chromosoma"},{"key":"2022010518015071500_R4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF00346017","article-title":"Synaptic interrelationships between the segments of the heteromorphic bivalent in double heterozygotes for paracentric inversions in chromosome 1 of the house mouse","volume":"101","author":"Borodin","year":"1992","journal-title":"Chromosoma"},{"key":"2022010518015071500_R5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1242\/dev.117.1.341","article-title":"A Y chromosomal effect on blastocyst cell number in mice","volume":"117","author":"Burgoyne","year":"1993","journal-title":"Development"},{"key":"2022010518015071500_R6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000056819","article-title":"A high frequency of XO offspring from X(Paf)Y* male mice: evidence that the Paf mutation involves an inversion spanning the X PAR boundary","volume":"91","author":"Burgoyne","year":"2000","journal-title":"Cytogenet. Cell Genet."},{"key":"2022010518015071500_R7","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1073\/pnas.131022798","article-title":"Evidence that replication fork components catalyze establishment of cohesion between sister chromatids","volume":"98","author":"Carson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. 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Cell Genet."},{"key":"2022010518015071500_R12","first-page":"123","article-title":"Meiosis and fertility in mice heterozygous for paracentric inversions","volume-title":"Current Chromosome Research, Kew Chromosome Conference","author":"Ford","year":"1976"},{"key":"2022010518015071500_R13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/hdy.1995.114","article-title":"Recombination in single and double heterozygotes for two partially overlapping inversions in chromosome 1 of the house mouse","volume":"75","author":"Gorlov","year":"1995","journal-title":"Heredity"},{"key":"2022010518015071500_R14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/106.2.185","article-title":"Meiotic and mitotic behavior of dicentric chromosomes in Saccharomyces cerevisiae","volume":"106","author":"Haber","year":"1984","journal-title":"Genetics"},{"key":"2022010518015071500_R15","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1242\/jcs.114.13.2417","article-title":"Coordinating the segregation of sister chromatids during the first meiotic division: evidence for sexual dimorphism","volume":"114","author":"Hodges","year":"2001","journal-title":"J. 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Cell Genet."},{"key":"2022010518015071500_R32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/genetics\/21.5.554","article-title":"The relations of inversions in the X chromosome of Drosophila melanogaster to crossing over and disjunction","volume":"21","author":"Sturtevant","year":"1936","journal-title":"Genetics"},{"key":"2022010518015071500_R33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000129914","article-title":"An air-drying method for chromosome preparations from mouse eggs","volume":"5","author":"Tarkowski","year":"1966","journal-title":"Cytogenetics"},{"key":"2022010518015071500_R34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00285827","article-title":"Further examination of the production-line hypothesis in mouse foetal oocytes. I. 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