{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T12:34:24Z","timestamp":1723293264199},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Parasites have profound effects on host ecology and evolution, and the effects of parasites on host ecology are often influenced by the magnitude of host susceptibility to parasites. Many parasites have complex life cycles that require intermediate hosts for their transmission, but little is known about the genetic basis of the intermediate host's susceptibility to these parasites. This study examined the genetic basis of susceptibility to a tapeworm (Hymenolepis diminuta) in the red flour beetle (Tribolium castaneum) that serves as an intermediate host in its transmission. Quantitative trait loci (QTL) mapping experiments were conducted with two independent segregating populations using amplified fragment length polymorphism (AFLP) markers and randomly amplified polymorphic DNA (RAPD) markers. A total of five QTL that significantly affected beetle susceptibility were identified in the two reciprocal crosses. Two common QTL on linkage groups 3 and 6 were identified in both crosses with similar effects on the phenotype, and three QTL were unique to each cross. In one cross, the three main QTL accounted for 29% of the total phenotypic variance and digenic epistasis explained 39% of the variance. In the second cross, the four main QTL explained 62% of the variance and digenic epistasis accounted for only 5% of the variance. The actions of these QTL were either overdominance or underdominance. Our results suggest that the polygenic nature of beetle susceptibility to the parasites and epistasis are important genetic mechanisms for the maintenance of variation within or among beetle strains in susceptibility to tapeworm infection.<\/jats:p>","DOI":"10.1093\/genetics\/165.3.1307","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T06:50:37Z","timestamp":1619592637000},"page":"1307-1315","source":"Crossref","is-referenced-by-count":20,"title":["Quantitative Trait Loci for Susceptibility to Tapeworm Infection in the Red Flour Beetle"],"prefix":"10.1093","volume":"165","author":[{"given":"Daibin","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, State University of New York, Buffalo, New York 14260"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, State University of New York, Buffalo, New York 14260"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, State University of New York, Buffalo, New York 14260"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"2022010522210751800_R1","doi-asserted-by":"crossref","first-page":"15503","DOI":"10.1073\/pnas.93.26.15503","article-title":"High-resolution mapping and isolation of a yeast artificial chromosome contig containing fw2.2: a major fruit weight quantitative trait locus in tomato","volume":"93","author":"Alpert","year":"1996","journal-title":"Proc. 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Nat."},{"key":"2022010522210751800_R21","first-page":"191","article-title":"A hypothesis to account for the maintenance of sex within populations","volume":"3","author":"Jaenike","year":"1978","journal-title":"Evol. 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Parasitol."},{"key":"2022010522210751800_R56","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1086\/285825","article-title":"Selection by parasites on components of fitness in Tribolium beetles: the effect of intraspecific competition","volume":"146","author":"Yan","year":"1995","journal-title":"Am. Nat."},{"key":"2022010522210751800_R57","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1086\/285635","article-title":"Behavioral changes in Tribolium beetles infected with a tapeworm: variation in effects between beetle species and among genetic strains","volume":"143","author":"Yan","year":"1994","journal-title":"Am. 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Hered."}],"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/165\/3\/1307\/42051398\/genetics1307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/165\/3\/1307\/42051398\/genetics1307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T22:30:03Z","timestamp":1641421803000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/165\/3\/1307\/6052798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,1]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,11,1]]},"published-print":{"date-parts":[[2003,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/165.3.1307","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,11,1]]},"published":{"date-parts":[[2003,11,1]]}}}