{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:38:43Z","timestamp":1787823523559,"version":"build-2784847793"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nuclear receptors regulate numerous critical biological processes. The C. elegans genome is predicted to encode \u223c270 nuclear receptors of which &amp;gt;250 are unique to nematodes. ODR-7 is the only member of this large divergent family whose functions have been defined genetically. ODR-7 is expressed in the AWA olfactory neurons and specifies AWA sensory identity by promoting the expression of AWA-specific signaling genes and repressing the expression of an AWC-specific olfactory receptor gene. To elucidate the molecular mechanisms of action of a divergent nuclear receptor, we have identified residues and domains required for different aspects of ODR-7 function in vivo. ODR-7 utilizes an unexpected diversity of mechanisms to regulate the expression of different sets of target genes. Moreover, these mechanisms are distinct in normal and heterologous cellular contexts. The odr-7 ortholog in the closely related nematode C. briggsae can fully substitute for all ODR-7-mediated functions, indicating conservation of function across 25\u2013120 million years of divergence.<\/jats:p>","DOI":"10.1093\/genetics\/165.4.1779","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T16:21:18Z","timestamp":1619540478000},"page":"1779-1791","source":"Crossref","is-referenced-by-count":31,"title":["The Divergent Orphan Nuclear Receptor ODR-7 Regulates Olfactory Neuron Gene Expression via Multiple Mechanisms in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"165","author":[{"given":"Marc E","family":"Colosimo","sequence":"first","affiliation":[{"name":"Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piali","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"2022010522431810600_R1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"key":"2022010522431810600_R2","doi-asserted-by":"crossref","first-page":"48479","DOI":"10.1074\/jbc.C200570200","article-title":"Mutations in the estrogen receptor DNA-binding domain discriminate between the classical mechanism of action and cross-talk with Stat5b and activating protein 1 (AP-1)","volume":"277","author":"Bjornstrom","year":"2002","journal-title":"J. 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