{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:34:17Z","timestamp":1792708457119,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1979,10,1]],"date-time":"1979-10-01T00:00:00Z","timestamp":307584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Tetraploid stocks of Caenorhabditis elegans var. Bristol carrying autosomal and X-linked markers have been produced. Tetraploid hermaphrodites fall into two categories: those that give about 1% male self-progeny and those that give 25 to 40% male self-progeny, The former are basically 4A;4X\u2014four sets of autosomes and four sex chromosomes\u2014and the latter are 4A;3X. Males are 4A;2X. (Diploid hermaphrodites are 2A;2X; males are 2A;IX.) Triploids wsre produced by crossing tetraploid hermaphrodites and diploid males. Triploids of composition 3A;3X are hermaphrodites; 3A;2X animals are fertile males. Different X-chromosome duplications were added to a 3A;2X chromosome constitution to increase the X-to-autosome ratio. Based on the resulting sexual phenotypes, we conclude that there exists on the C. elegans X chromosome at least three (and perhaps many mare) dose-sensitive sites that act cumulatively in determining sex.<\/jats:p>","DOI":"10.1093\/genetics\/93.2.393","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:22:55Z","timestamp":1619097775000},"page":"393-402","source":"Crossref","is-referenced-by-count":161,"title":["POLYPLOIDS AND SEX DETERMINATION IN <i>CAENORHABDITIS ELEGANS<\/i>"],"prefix":"10.1093","volume":"93","author":[{"given":"James E","family":"Madl","sequence":"first","affiliation":[{"name":"Department of Genetics and Cell Biology, University of Minnesota, Saint Paul, Minnesota 55108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, University of Minnesota, Saint Paul, Minnesota 55108"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1979,10,1]]},"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/93\/2\/393\/34425128\/genetics0393.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/93\/2\/393\/34425128\/genetics0393.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:22:56Z","timestamp":1619097776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/93\/2\/393\/5993504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/93.2.393","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,10,1]]},"published":{"date-parts":[[1979,10,1]]}}}