{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:32:41Z","timestamp":1754487161879},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3-4","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A temperature-sensitive (ts) third chromosome Minute (M) mutation, designated Q-III, has been recovered and characterized. Q-III heterozygotes raised at 29\" exhibit all of the dominant traits of M mutants including small bristles, rough eyes, prolonged development, reduced viability 2nd interactions with several unrelated mutations. Q-III homozygotes raised at 29\u00b0 are lethal; death occurs primarily during the first larval instar. When raised at 22\u00b0, Q-Ill heterozygotes are phenotypically normal and Q-III homozygotes display moderate Mtraits. In addition, Q-IIIelicits ts sterility and maternal-effect lethality. As it true of Mlesions, the dominant traits of Q-111 are not expressed in triploid females raised at 29\u00b0. Complementation tests suggest that Q-III is a ts allele of M(3)LS4, which is located in 3L near the centromere.\u2014\u2014Reciprocal temperature-shift experiments revealed that the temperature-sensitive period (TSP) of Q-111 lethality is polyphasic, extending from the first instar to the latter half of pupation. Heat-pulse experiments further resolved this into two post-embryonic TSPs: one occurring during the latter half of the second larval instar, and the other extending from the larval\/pupal boundary to the second half of pupation. In addition, heat pulses elicited a large number of striking adult phenotypes in Q-III individuals. These included pattern alterations such as deficiencies and duplications and cther morphological defects in structures produced by the eye-antennal, leg, wing and genital imaginal discs and the abdominal histoblasts. Each defect or pattern alteration is associated with a specific TSP during development.\u2014\u2014We favor the interpretation that most of the major Q-III defects, particularly the structural duplications and deficiencies, result from temperature-induced cell death in mitotically active imaginal anlagen, while the small macrochaete phene probably results from the direct effects of Q-III on bristle synthesis. The hypothesis that the Q-III locus specifices a component required for protein synthesis is discussed, and it is concluded that this hypothesis can account for the pleiotropy of Q-III, and that perhaps it can be extended to M loci in general.<\/jats:p>","DOI":"10.1093\/genetics\/97.3-4.581","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T16:19:21Z","timestamp":1619108361000},"page":"581-606","source":"Crossref","is-referenced-by-count":19,"title":["GENETIC AND DEVELOPMENTAL ANALYSIS OF A TEMPERATURE-SENSITIVE MINUTE MUTATION OF <i>DROSOPHILA MELANOGASTER<\/i>"],"prefix":"10.1093","volume":"97","author":[{"given":"Donald A R","family":"Sinclair","sequence":"first","affiliation":[{"name":"Department of Zoology, The University of British Columbia, Vancouver, B.C., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Zoology, The University of British Columbia, Vancouver, B.C., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A","family":"Grigliatti","sequence":"additional","affiliation":[{"name":"Department of Zoology, The University of British Columbia, Vancouver, B.C., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,3,1]]},"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/97\/3-4\/581\/35643273\/genetics0581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/genetics\/article-pdf\/97\/3-4\/581\/35643273\/genetics0581.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T16:19:23Z","timestamp":1619108363000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/97\/3-4\/581\/5994468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1981,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/97.3-4.581","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1981,3,1]]},"published":{"date-parts":[[1981,3,1]]}}}