{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:10:09Z","timestamp":1790475009356,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program"},{"name":"Marie Sklodowska-Curie","award":["H2020-MSCA-ITN-2014-642095"],"award-info":[{"award-number":["H2020-MSCA-ITN-2014-642095"]}]},{"name":"Spanish Ministry of Economy, Industry, and Competitiveness","award":["PGC2018-099921-B-I00"],"award-info":[{"award-number":["PGC2018-099921-B-I00"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CERCA Programme\/Generalitat de Catalunya"},{"name":"Catalan Research Agency","award":["SGR857"],"award-info":[{"award-number":["SGR857"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["ERC-2016-724173"],"award-info":[{"award-number":["ERC-2016-724173"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["MSCA-747607"],"award-info":[{"award-number":["MSCA-747607"]}]},{"name":"INB","award":["PT17\/0009\/0023"],"award-info":[{"award-number":["PT17\/0009\/0023"]}]},{"name":"INB","award":["ISCIII-SGEFI\/ERDF"],"award-info":[{"award-number":["ISCIII-SGEFI\/ERDF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida albicans is the most commonly reported species causing candidiasis. The taxonomic classification of C. albicans and related lineages is controversial, with Candida africana (syn. C. albicans var. africana) and Candida stellatoidea (syn. C. albicans var. stellatoidea) being considered different species or C. albicans varieties depending on the authors. Moreover, recent genomic analyses have suggested a shared hybrid origin of C. albicans and C. africana, but the potential parental lineages remain unidentified. Although the genomes of C. albicans and C. africana have been extensively studied, the genome of C. stellatoidea has not been sequenced so far. In order to get a better understanding of the evolution of the C. albicans clade, and to assess whether C. stellatoidea could represent one of the unknown C. albicans parental lineages, we sequenced C. stellatoidea type strain (CBS 1905). This genome was compared to that of C. albicans and of the closely related lineage C. africana. Our results show that, similarly to C. africana, C. stellatoidea descends from the same hybrid ancestor as other C. albicans strains and that it has undergone a parallel massive loss of heterozygosity.<\/jats:p>","DOI":"10.1093\/genetics\/iyaa004","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T14:34:48Z","timestamp":1612881288000},"source":"Crossref","is-referenced-by-count":21,"title":["Extreme diversification driven by parallel events of massive loss of heterozygosity in the hybrid lineage of <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"217","author":[{"given":"Ver\u00f3nica","family":"Mix\u00e3o","sequence":"first","affiliation":[{"name":"Life Sciences Department, Barcelona Supercomputing Center (BSC) , 08034 Barcelona, Spain"},{"name":"Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology , 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Saus","sequence":"additional","affiliation":[{"name":"Life Sciences Department, Barcelona Supercomputing Center (BSC) , 08034 Barcelona, Spain"},{"name":"Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology , 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Boekhout","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute , 3584 CT Utrecht, The Netherlands"},{"name":"Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam , 1090 GE Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Gabald\u00f3n","sequence":"additional","affiliation":[{"name":"Life Sciences Department, Barcelona Supercomputing Center (BSC) , 08034 Barcelona, Spain"},{"name":"Mechanisms of Disease Department, Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology , 08028 Barcelona, Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA) , 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"2024022117341828300_iyaa004-B1","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1007\/s00018-010-0421-8","article-title":"Sexual reproduction in the Candida clade: cryptic cycles, diverse mechanisms, and alternative functions","volume":"67","author":"Alby","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"2024022117341828300_iyaa004-B2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1534\/genetics.118.301482","article-title":"Diverse lineages of Candida albicans live on Old 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