{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:38:05Z","timestamp":1772138285627,"version":"3.50.1"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health Public Health Service","award":["R21AI128103"],"award-info":[{"award-number":["R21AI128103"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32AI007025"],"award-info":[{"award-number":["T32AI007025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The gram-negative bacterium Coxiella burnetii is the causative agent of Query (Q) fever in humans and coxiellosis in livestock. Host genetics are associated with C. burnetii pathogenesis both in humans and animals; however, it remains unknown if specific genes are associated with severity of infection. We employed the Drosophila Genetics Reference Panel to perform a genome-wide association study to identify host genetic variants that affect host survival to C. burnetii infection. The genome-wide association study identified 64 unique variants (P\u2009&amp;lt;\u200910\u22125) associated with 25 candidate genes. We examined the role each candidate gene contributes to host survival during C. burnetii infection using flies carrying a null mutation or RNAi knockdown of each candidate. We validated 15 of the 25 candidate genes using at least one method. This is the first report establishing involvement of many of these genes or their homologs with C. burnetii susceptibility in any system. Among the validated genes, FER and tara play roles in the JAK\/STAT, JNK, and decapentaplegic\/TGF-\u03b2 signaling pathways which are components of known innate immune responses to C. burnetii infection. CG42673 and DIP-\u03b5 play roles in bacterial infection and synaptic signaling but have no previous association with C. burnetii pathogenesis. Furthermore, since the mammalian ortholog of CG13404 (PLGRKT) is an important regulator of macrophage function, CG13404 could play a role in host susceptibility to C. burnetii through hemocyte regulation. These insights provide a foundation for further investigation regarding the genetics of C. burnetii susceptibility across a wide variety of hosts.<\/jats:p>","DOI":"10.1093\/genetics\/iyab005","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T18:37:03Z","timestamp":1611427023000},"source":"Crossref","is-referenced-by-count":9,"title":["Natural genetic variation in\n                    <i>Drosophila melanogaster<\/i>\n                    reveals genes associated with\n                    <i>Coxiella burnetii<\/i>\n                    infection"],"prefix":"10.1093","volume":"217","author":[{"given":"Rosa M","family":"Guzman","sequence":"first","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary P","family":"Howard","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziying","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan D","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisha T","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Omsland","sequence":"additional","affiliation":[{"name":"Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen N","family":"White","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"},{"name":"USDA-ARS Animal Disease Research, Pullman, WA 99164, USA"},{"name":"Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-332X","authenticated-orcid":false,"given":"Alan G","family":"Goodman","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"},{"name":"Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"2021033120173179700_iyab005-B1","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.cub.2015.05.037","article-title":"TARANIS functions with cyclin A and Cdk1 in a novel arousal center to control sleep in Drosophila","volume":"25","author":"Afonso","year":"2015","journal-title":"Curr Biol"},{"key":"2021033120173179700_iyab005-B2","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1128\/IAI.00301-09","article-title":"Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii","volume":"77","author":"Aguilera","year":"2009","journal-title":"Infect 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