{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:02:30Z","timestamp":1762390950661,"version":"3.41.2"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Extra-mural Research","award":["EMR\/2016\/004978"],"award-info":[{"award-number":["EMR\/2016\/004978"]}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ramanujan Fellowship","award":["SR\/S2\/RJN-140\/2011"],"award-info":[{"award-number":["SR\/S2\/RJN-140\/2011"]}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Science and Technology, Inspire studentship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Insulin signaling in Drosophila has a significant role in regulating growth, metabolism, fecundity, stress response, and longevity. The molecular mechanism by which insulin signaling regulates these vital processes is dependent on the nutrient status and oxygen availability of the organism. In a genetic screen to identify novel genes that regulate Drosophila insulin signaling, we discovered lumens interrupted (lint), a gene that has previously been shown to act in tracheal development. The knockdown of lint gene expression using a Dilp2Gal4 driver which expresses in the neuronal insulin producing cells (IPCs), led to defects in systemic insulin signaling, metabolic status and growth. However, our analysis of lint knockdown phenotypes revealed that downregulation of lint in the trachea and not IPCs was responsible for the growth phenotypes, as the Gal4 driver is also expressed in the tracheal system. We found various tracheal terminal branch defects, including reduction in the length as well as number of branches in the lint knockdown background. Our study reveals that substantial effects of lint downregulation arose because of tracheal defects, which induced tissue hypoxia, altered systemic insulin\/TOR signaling, and resulted in effects on developmental growth regulation.<\/jats:p>","DOI":"10.1093\/genetics\/iyab035","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T08:59:41Z","timestamp":1615453181000},"source":"Crossref","is-referenced-by-count":1,"title":["Lint, a transmembrane serine protease, regulates growth and metabolism in <i>Drosophila<\/i>"],"prefix":"10.1093","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0423","authenticated-orcid":false,"given":"Himani","family":"Pathak","sequence":"first","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research (IISER TVM), Maruthamala Post, Vithura, Thiruvananthapuram, Kerala 695551, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananthakrishnan","family":"Vijaykumar Maya","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Immunobiology and Epigenetics, St\u00fcbeweg 51, 79108 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Basith","family":"Tanari","sequence":"additional","affiliation":[{"name":"Universite de C\u00f4te d\u2019Azur, iBV\u2014Institut de Biologie Valrose, Bat. Sciences Naturalles, Park Valrose, 28, Avenue Valrose, 06108 Nice Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohela","family":"Sarkar","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research (IISER TVM), Maruthamala Post, Vithura, Thiruvananthapuram, Kerala 695551, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-3094","authenticated-orcid":false,"given":"Jishy","family":"Varghese","sequence":"additional","affiliation":[{"name":"School of Biology, Indian Institute of Science Education and Research (IISER TVM), Maruthamala Post, Vithura, Thiruvananthapuram, Kerala 695551, 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