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Behavioral remodeling may be acute in animals that interact with host organisms, since reproductive adults and the developmentally arrested larvae often have different ethological needs for chemical stimuli. To understand the genes that coordinate the development and host-seeking behavior, we used the entomophilic nematode Pristionchus pacificus to characterize dauer-constitutive mutants (Daf-c) that inappropriately enter developmental diapause to become dauer larvae. We found two Daf-c loci with dauer-constitutive and cuticle exsheathment phenotypes that can be rescued by the feeding of \u03947-dafachronic acid, and that are dependent on the conserved canonical steroid hormone receptor Ppa-DAF-12. Specifically at one locus, deletions in the sole hydroxysteroid dehydrogenase (HSD) in P. pacificus resulted in Daf-c phenotypes. Ppa-hsd-2 is expressed in the canal-associated neurons (CANs) and excretory cells whose homologous cells in Caenorhabditis elegans are not known to be involved in the dauer decision. While in wildtype only dauer larvae are attracted to host odors, hsd-2 mutant adults show enhanced attraction to the host beetle pheromone, along with ectopic activation of a marker for putative olfactory neurons, Ppa-odr-3. Surprisingly, this enhanced odor attraction acts independently of the \u03947-DA\/DAF-12 module, suggesting that Ppa-HSD-2 may be responsible for several steroid hormone products involved in coordinating the dauer decision and host-seeking behavior in P. pacificus.<\/jats:p>","DOI":"10.1093\/genetics\/iyab071","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T18:57:32Z","timestamp":1620500252000},"source":"Crossref","is-referenced-by-count":11,"title":["Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in <i>Pristionchus pacificus<\/i>"],"prefix":"10.1093","volume":"218","author":[{"given":"Heather R","family":"Carstensen","sequence":"first","affiliation":[{"name":"Department of Biology, California State University, Northridge, Northridge, CA 91330-8303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinard M","family":"Villalon","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University, Northridge, Northridge, CA 91330-8303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navonil","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology & Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-3174","authenticated-orcid":false,"given":"Elissa A","family":"Hallem","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology & Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-8659","authenticated-orcid":false,"given":"Ray L","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University, Northridge, Northridge, CA 91330-8303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"2021091718263397400_iyab071-B1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cne.902190407","article-title":"Developmental alterations in sensory neuroanatomy of the Caenorhabditis elegans dauer larva","volume":"219","author":"Albert","year":"1983","journal-title":"J Comp Neurol"},{"key":"2021091718263397400_iyab071-B2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"key":"2021091718263397400_iyab071-B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12862-015-0466-2","article-title":"Ancient gene duplications have shaped developmental 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