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We have previously shown that homeostatic feedback of embryo accumulation in the uterus regulates bursting activity of the serotonergic HSN command neurons that sustains the egg-laying active state. How sensory feedback of egg release signals to terminate the egg-laying active state is less understood. We find that G\u03b1o, a conserved Pertussis Toxin-sensitive G protein, signals within HSN to inhibit egg-laying circuit activity and prevent entry into the active state. G\u03b1o signaling hyperpolarizes HSN, reducing HSN Ca2+ activity and input onto the postsynaptic vulval muscles. Loss of inhibitory G\u03b1o signaling uncouples presynaptic HSN activity from a postsynaptic, stretch-dependent homeostat, causing precocious entry into the egg-laying active state when only a few eggs are present in the uterus. Feedback of vulval opening and egg release activates the uv1 neuroendocrine cells which release NLP-7 neuropeptides which signal to inhibit egg laying through G\u03b1o-independent mechanisms in the HSNs and G\u03b1o-dependent mechanisms in cells other than the HSNs. Thus, neuropeptide and inhibitory G\u03b1o signaling maintain a bi-stable state of electrical excitability that dynamically controls circuit activity in response to both external and internal sensory input to drive a two-state behavior output.<\/jats:p>","DOI":"10.1093\/genetics\/iyab080","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T08:41:52Z","timestamp":1622018512000},"source":"Crossref","is-referenced-by-count":26,"title":["Presynaptic G\u03b1o (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"218","author":[{"given":"Bhavya","family":"Ravi","sequence":"first","affiliation":[{"name":"Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA"},{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, 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