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Subsequent to its establishment during embryogenesis, neuronal architecture is maintained throughout life in the face of the animal\u2019s growth, maturation processes, the addition of new neurons, body movements, and aging. The Caenorhabditis elegans protein SAX-7, homologous to the vertebrate L1 protein family of neural adhesion molecules, is required for maintaining the organization of neuronal ganglia and fascicles after their successful initial embryonic development. To dissect the function of sax-7 in neuronal maintenance, we generated a null allele and sax-7S-isoform-specific alleles. We find that the null sax-7(qv30) is, in some contexts, more severe than previously described mutant alleles and that the loss of sax-7S largely phenocopies the null, consistent with sax-7S being the key isoform in neuronal maintenance. Using a sfGFP::SAX-7S knock-in, we observe sax-7S to be predominantly expressed across the nervous system, from embryogenesis to adulthood. Yet, its role in maintaining neuronal organization is ensured by postdevelopmentally acting SAX-7S, as larval transgenic sax-7S(+) expression alone is sufficient to profoundly rescue the null mutants\u2019 neuronal maintenance defects. Moreover, the majority of the protein SAX-7 appears to be cleaved, and we show that these cleaved SAX-7S fragments together, not individually, can fully support neuronal maintenance. These findings contribute to our understanding of the role of the conserved protein SAX-7\/L1CAM in long-term neuronal maintenance and may help decipher processes that go awry in some neurodegenerative conditions.<\/jats:p>","DOI":"10.1093\/genetics\/iyab086","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:59:15Z","timestamp":1623412755000},"source":"Crossref","is-referenced-by-count":12,"title":["Neuronal postdevelopmentally acting SAX-7S\/L1CAM can function as cleaved fragments to maintain neuronal architecture in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"218","author":[{"given":"Virginie E","family":"Desse","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, CERMO-FC Research Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC H2X 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra R","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Nadour","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, CERMO-FC Research Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC H2X 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Perrat","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Rivollet","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, CERMO-FC Research Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC H2X 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anagha","family":"Khandekar","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire Y","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, CERMO-FC Research Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC H2X 1Y4, Canada"},{"name":"Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"2022022205482850300_iyab086-B1","author":"Ackermann","year":"2017"},{"key":"2022022205482850300_iyab086-B2","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1523\/JNEUROSCI.13-11-04764.1993","article-title":"Several extracellular domains of the neural cell adhesion molecule L1 are involved in neurite outgrowth and cell body adhesion","volume":"13","author":"Appel","year":"1993","journal-title":"J Neurosci"},{"key":"2022022205482850300_iyab086-B3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1534\/genetics.114.169730","article-title":"Efficient marker-free recovery of custom genetic modifications with CRISPR\/Cas9 in Caenorhabditis 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