{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:59:17Z","timestamp":1790812757648,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DK116768"],"award-info":[{"award-number":["R01 DK116768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL112281"],"award-info":[{"award-number":["HL112281"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013759","name":"Commonwealth Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Atherosclerosis is the underlying cause of heart attack, ischemic stroke and peripheral arterial disease, and genetic factors involved remain mostly unidentified. We previously identified a significant locus on mouse chromosome 17 for atherosclerosis, Ath49, in an intercross between BALB\/c and SM strains. Ath49 partially overlaps in the confidence interval with Ath22 mapped in an AKR \u00d7 DBA\/2 intercross. Bioinformatics analysis prioritized Mep1a, encoding meprin 1\u03b1 metalloendopeptidase, as a likely candidate gene for Ath49. To prove causality, Mep1a\u2212\/\u2212Apoe\u2212\/\u2212 mice were generated and compared with Mep1a+\/+Apoe\u2212\/\u2212 mice for atherosclerosis development. Mep1a was found abundantly expressed in atherosclerotic lesions but not in healthy aorta and liver of mice. Mep1a\u2212\/\u2212 Apoe\u2212\/\u2212 mice exhibited significant reductions in both early and advanced lesion sizes. Loss of Mep1a led to decreased necrosis but increased macrophage and neutrophil contents in advanced lesions, reduced plasma levels of CXCL5 and an oxidative stress biomarker. In addition, Mep1a\u2212\/\u2212 mice had significantly reduced triglyceride levels on a chow diet. Thus, Mep1a is a susceptibility gene for atherosclerosis and aggravates atherosclerosis partially through action on oxidative stress and inflammation.<\/jats:p>","DOI":"10.1093\/genetics\/iyab160","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T13:14:41Z","timestamp":1632921281000},"source":"Crossref","is-referenced-by-count":11,"title":["Identification of <i>Mep1a<\/i> as a susceptibility gene for atherosclerosis in mice"],"prefix":"10.1093","volume":"219","author":[{"given":"Andrew T.","family":"Grainger","sequence":"first","affiliation":[{"name":"Departments of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA"},{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael","family":"Pilar","sequence":"additional","affiliation":[{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-0799","authenticated-orcid":false,"given":"Ashley M.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker-Pauly","sequence":"additional","affiliation":[{"name":"Biochemical Institute, Kiel University, Kiel D-24118, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9155-613X","authenticated-orcid":false,"given":"Weibin","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA"},{"name":"Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"2022020900355940000_iyab160-B1","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.bbamcr.2017.05.011","article-title":"Meprin metalloproteases: molecular regulation and function in inflammation and fibrosis","volume":"1864","author":"Arnold","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2022020900355940000_iyab160-B2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/mi.2009.3","article-title":"MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease","volume":"2","author":"Banerjee","year":"2009","journal-title":"Mucosal Immunol"},{"key":"2022020900355940000_iyab160-B3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/abbi.1996.0286","article-title":"Expression and distribution of meprin protease subunits in mouse intestine","volume":"331","author":"Bankus","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"2022020900355940000_iyab160-B4","doi-asserted-by":"crossref","first-page":"e1005711","DOI":"10.1371\/journal.pgen.1005711","article-title":"Genetic architecture of atherosclerosis in mice: a systems genetics analysis of common inbred strains","volume":"11","author":"Bennett","year":"2015","journal-title":"PLoS Genet"},{"key":"2022020900355940000_iyab160-B5","doi-asserted-by":"crossref","first-page":"14219","DOI":"10.1073\/pnas.1305464110","article-title":"Metalloproteases meprin \u03b1 and meprin \u03b2 are C- and N-procollagen proteinases important for collagen assembly and tensile strength","volume":"110","author":"Broder","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022020900355940000_iyab160-B6","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1194\/jlr.M400092-JLR200","article-title":"Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility","volume":"45","author":"Brown","year":"2004","journal-title":"J Lipid Res"},{"key":"2022020900355940000_iyab160-B8","doi-asserted-by":"crossref","first-page":"25277","DOI":"10.1016\/S0021-9258(18)47243-2","article-title":"Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene","volume":"269","author":"Chang","year":"1994","journal-title":"J Biol Chem"},{"key":"2022020900355940000_iyab160-B9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng.782","article-title":"A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease","volume":"43","year":"2011","journal-title":"Nat Genet"},{"key":"2022020900355940000_iyab160-B7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"Deloukas","year":"2013","journal-title":"Nat Genet"},{"key":"2022020900355940000_iyab160-B10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol Rev"},{"key":"2022020900355940000_iyab160-B11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/eurheartj\/ehs411","article-title":"Update on acute coronary syndromes: the pathologists\u2019 view","volume":"34","author":"Falk","year":"2013","journal-title":"Eur Heart J"},{"key":"2022020900355940000_iyab160-B12","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1134\/S0006297916110134","article-title":"The role of cytokines in the development of atherosclerosis","volume":"81","author":"Fatkhullina","year":"2016","journal-title":"Biochemistry (Mosc)"},{"key":"2022020900355940000_iyab160-B13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/imammb\/dqr012","article-title":"Growth of necrotic cores in atherosclerotic plaque","volume":"29","author":"Fok","year":"2012","journal-title":"Math Med Biol"},{"key":"2022020900355940000_iyab160-B14","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1038\/s41467-018-07340-5","article-title":"GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes","volume":"9","author":"Franceschini","year":"2018","journal-title":"Nat Commun"},{"key":"2022020900355940000_iyab160-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2019.11.034","article-title":"Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains","volume":"293","author":"Fuller","year":"2020","journal-title":"Atherosclerosis"},{"key":"2022020900355940000_iyab160-B16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.atherosclerosis.2009.04.036","article-title":"A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-\/- mice","volume":"207","author":"Gao","year":"2009","journal-title":"Atherosclerosis"},{"key":"2022020900355940000_iyab160-B17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrneph.2017.51","article-title":"The immunology of atherosclerosis","volume":"13","author":"Gister\u00e5","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2022020900355940000_iyab160-B18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2016.10.011","article-title":"Genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice","volume":"254","author":"Grainger","year":"2016","journal-title":"Atherosclerosis"},{"key":"2022020900355940000_iyab160-B19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2008.12.161","article-title":"Meprin A and meprin \u03b1 generate biologically functional IL-1\u03b2 from pro-IL-1\u03b2","volume":"379","author":"Herzog","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"2022020900355940000_iyab160-B20","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1172\/JCI117179","article-title":"Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice","volume":"93","author":"Ishibashi","year":"1994","journal-title":"J Clin Invest"},{"key":"2022020900355940000_iyab160-B21","doi-asserted-by":"crossref","first-page":"10380","DOI":"10.1016\/S0021-9258(18)82212-8","article-title":"Tissue-specific expression and chromosomal localization of the alpha subunit of mouse meprin A","volume":"268","author":"Jiang","year":"1993","journal-title":"J Biol Chem"},{"key":"2022020900355940000_iyab160-B22","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1534\/g3.120.401856","article-title":"Regional variation in genetic control of atherosclerosis in hyperlipidemic mice","volume":"10","author":"Jones","year":"2020","journal-title":"G3 (Bethesda)."},{"key":"2022020900355940000_iyab160-B23","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1074\/jbc.M113.546309","article-title":"Meprin metalloproteases inactivate interleukin 6","volume":"289","author":"Keiffer","year":"2014","journal-title":"J Biol Chem"},{"key":"2022020900355940000_iyab160-B24","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1038\/jid.2010.202","article-title":"Processing of procollagen III by Meprins: new players in extracellular matrix assembly?","volume":"130","author":"Kronenberg","year":"2010","journal-title":"J Invest Dermatol"},{"key":"2022020900355940000_iyab160-B25","doi-asserted-by":"crossref","first-page":"H1056","DOI":"10.1152\/ajpheart.00366.2011","article-title":"Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression","volume":"301","author":"Manichaikul","year":"2011","journal-title":"Am J Physiol Circ Physiol"},{"key":"2022020900355940000_iyab160-B26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.immuni.2010.07.009","article-title":"CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection","volume":"33","author":"Mei","year":"2010","journal-title":"Immunity"},{"key":"2022020900355940000_iyab160-B27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.lfs.2006.01.043","article-title":"Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice","volume":"79","author":"Miyoshi","year":"2006","journal-title":"Life Sci"},{"key":"2022020900355940000_iyab160-B28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.atherosclerosis.2005.12.001","article-title":"Differential response of vascular smooth muscle cells to oxidized LDL in mouse strains with different atherosclerosis susceptibility","volume":"189","author":"Miyoshi","year":"2006","journal-title":"Atherosclerosis"},{"key":"2022020900355940000_iyab160-B29","first-page":"29","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"2022020900355940000_iyab160-B30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","article-title":"ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree","volume":"14","author":"Nakashima","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"2022020900355940000_iyab160-B31","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/ng.3913","article-title":"Association analyses based on false discovery rate implicate new loci for coronary artery disease","volume":"49","author":"Nelson","year":"2017","journal-title":"Nat Genet"},{"key":"2022020900355940000_iyab160-B32","first-page":"1121","article-title":"A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary arterydisease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat Genet"},{"key":"2022020900355940000_iyab160-B33","first-page":"1480","article-title":"Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification","volume":"14","author":"Qiao","year":"1994","journal-title":"Arterioscler Thromb J Vasc Biol Am Heart Assoc"},{"key":"2022020900355940000_iyab160-B34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0008-6363(98)00321-6","article-title":"Collagen synthesis in atherosclerosis: too much and not enough","volume":"41","author":"Rekhter","year":"1999","journal-title":"Cardiovasc Res"},{"key":"2022020900355940000_iyab160-B35","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI66580","article-title":"CXCL5 limits macrophage foam cell formation in atherosclerosis","volume":"123","author":"Rousselle","year":"2013","journal-title":"J Clin Invest"},{"key":"2022020900355940000_iyab160-B36","doi-asserted-by":"crossref","first-page":"e000260","DOI":"10.1161\/JAHA.113.000260","article-title":"Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain","volume":"2","author":"Rowlan","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2022020900355940000_iyab160-B37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"2022020900355940000_iyab160-B38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.CIR.102.1.75","article-title":"Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice","volume":"102","author":"Shi","year":"2000","journal-title":"Circulation"},{"key":"2022020900355940000_iyab160-B39","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/01.RES.86.10.1078","article-title":"Determinants of atherosclerosis susceptibility in the C3H and C57BL\/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism","volume":"86","author":"Shi","year":"2000","journal-title":"Circ Res"},{"key":"2022020900355940000_iyab160-B40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbrc.2004.03.037","article-title":"Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice","volume":"317","author":"Shi","year":"2004","journal-title":"Biochem. Biophys. Res Commun"},{"key":"2022020900355940000_iyab160-B41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.amjms.2021.06.014","article-title":"Hyperlipidemia influences the accuracy of glucometer-measured blood glucose concentrations in genetically diverse mice","volume":"362","author":"Shi","year":"2021","journal-title":"Am J Med Sci"},{"key":"2022020900355940000_iyab160-B42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/01.ATV.0000201044.33220.5c","article-title":"Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan","volume":"26","author":"Smith","year":"2006","journal-title":"ATVB"},{"key":"2022020900355940000_iyab160-B43","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1534\/genetics.105.051912","article-title":"Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL\/6 and C3H mice carrying the mutant apolipoprotein E gene","volume":"172","author":"Su","year":"2006","journal-title":"Genetics"},{"key":"2022020900355940000_iyab160-B44","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.exphem.2008.10.016","article-title":"Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells","volume":"37","author":"Sun","year":"2009","journal-title":"Exp Hematol"},{"key":"2022020900355940000_iyab160-B45","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bbrc.2005.02.090","article-title":"Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility","volume":"329","author":"Tian","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"2022020900355940000_iyab160-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2015.123","article-title":"SIFT missense predictions for genomes","volume":"11","author":"Vaser","year":"2016","journal-title":"Nat Protoc"},{"key":"2022020900355940000_iyab160-B47","first-page":"50933","article-title":"Quantitative analysis and characterization of atherosclerotic lesions in the murine aortic sinus","author":"Venegas-Pino","year":"2013","journal-title":"J Vis Exp"},{"key":"2022020900355940000_iyab160-B48","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1093\/eurheartj\/ehz008","article-title":"Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis","volume":"40","author":"Vromman","year":"2019","journal-title":"Eur Heart J"},{"key":"2022020900355940000_iyab160-B49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12863-015-0292-y","article-title":"Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB\/cJ and SM\/J Apoe-deficient mouse strains","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Genet"},{"key":"2022020900355940000_iyab160-B50","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1161\/hh0202.105292","article-title":"Interleukin-18 enhances atherosclerosis in apolipoprotein E(-\/-) mice through release of interferon-gamma","volume":"90","author":"Whitman","year":"2002","journal-title":"Circ Res"},{"key":"2022020900355940000_iyab160-B51","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1073\/pnas.0130101100","article-title":"Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse","volume":"100","author":"Wiltshire","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022020900355940000_iyab160-B52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10554-009-9520-8","article-title":"Relation of plaque size to compositions as determined by an in vivo volumetric intravascular ultrasound radiofrequency analysis","volume":"26","author":"Xu","year":"2010","journal-title":"Int J Cardiovasc Imaging"},{"key":"2022020900355940000_iyab160-B53","doi-asserted-by":"crossref","first-page":"H1336","DOI":"10.1152\/ajpheart.01095.2008","article-title":"Microarray analysis of gene expression in mouse aorta reveals role of the calcium signaling pathway in control of atherosclerosis susceptibility","volume":"296","author":"Yuan","year":"2009","journal-title":"Am J Physiol Circ Physiol"},{"key":"2022020900355940000_iyab160-B54","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000502691","article-title":"Atherogenesis in the carotid artery with and without interrupted blood flow of two hyperlipidemic mouse strains","volume":"56","author":"Zhao","year":"2019","journal-title":"J Vasc Res"}],"container-title":["Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyab160\/41270859\/iyab160.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/219\/4\/iyab160\/42391177\/iyab160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/219\/4\/iyab160\/42391177\/iyab160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:41:04Z","timestamp":1644367264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyab160\/6377788"}},"subtitle":[],"editor":[{"given":"A.","family":"Ralston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,9,29]]},"published-print":{"date-parts":[[2021,12,10]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyab160","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,9,29]]},"article-number":"iyab160"}}