{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:09:37Z","timestamp":1777468177754,"version":"3.51.4"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS045873"],"award-info":[{"award-number":["R01NS045873"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>L1CAMs are immunoglobulin cell adhesion molecules that function in nervous system development and function. Besides being associated with autism and schizophrenia spectrum disorders, impaired L1CAM function also underlies the X-linked L1 syndrome, which encompasses a group of neurological conditions, including spastic paraplegia and congenital hydrocephalus. Studies on vertebrate and invertebrate L1CAMs established conserved roles that include axon guidance, dendrite morphogenesis, synapse development, and maintenance of neural architecture. We previously identified a genetic interaction between the Caenorhabditis elegans L1CAM encoded by the sax-7 gene and RAB-3, a GTPase that functions in synaptic neurotransmission; rab-3; sax-7 mutant animals exhibit synthetic locomotion abnormalities and neuronal dysfunction. Here, we show that this synergism also occurs when loss of SAX-7 is combined with mutants of other genes encoding key players of the synaptic vesicle (SV) cycle. In contrast, sax-7 does not interact with genes that function in synaptogenesis. These findings suggest a postdevelopmental role for sax-7 in the regulation of synaptic activity. To assess this possibility, we conducted electrophysiological recordings and ultrastructural analyses at neuromuscular junctions; these analyses did not reveal obvious synaptic abnormalities. Lastly, based on a forward genetic screen for suppressors of the rab-3; sax-7 synthetic phenotypes, we determined that mutants in the ERK Mitogen-activated Protein Kinase (MAPK) pathway can suppress the rab-3; sax-7 locomotion defects. Moreover, we established that Erk signaling acts in a subset of cholinergic neurons in the head to promote coordinated locomotion. In combination, these results suggest a modulatory role for Erk MAPK in L1CAM-dependent locomotion in C. elegans.<\/jats:p>","DOI":"10.1093\/genetics\/iyab215","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:31:25Z","timestamp":1638322285000},"source":"Crossref","is-referenced-by-count":7,"title":["A role for the Erk MAPK pathway in modulating SAX-7\/L1CAM-dependent locomotion in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"220","author":[{"given":"Melinda","family":"Moseley-Alldredge","sequence":"first","affiliation":[{"name":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"},{"name":"Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-856X","authenticated-orcid":false,"given":"Seema","family":"Sheoran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Illinois, Chicago, IL 60607, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-7734","authenticated-orcid":false,"given":"Lihsia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"},{"name":"Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"2022042009354463300_iyab215-B1","doi-asserted-by":"crossref","first-page":"e12018","DOI":"10.1371\/journal.pone.0012018","article-title":"CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex","volume":"5","author":"Andreyeva","year":"2010","journal-title":"PLoS 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