{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:05:46Z","timestamp":1790604346845,"version":"4.1.0"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health","doi-asserted-by":"crossref","award":["R01-HD073439"],"award-info":[{"award-number":["R01-HD073439"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health","doi-asserted-by":"crossref","award":["R01-HD094787"],"award-info":[{"award-number":["R01-HD094787"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation Graduate Research Fellowship Program","award":["DGE-1313190"],"award-info":[{"award-number":["DGE-1313190"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB-1754096"],"award-info":[{"award-number":["DEB-1754096"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Student Research from the Society for the Study of Evolution"},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB-2012041"],"award-info":[{"award-number":["DEB-2012041"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/N000463\/1"],"award-info":[{"award-number":["BB\/N000463\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","award":["RPG-2019-414 194"],"award-info":[{"award-number":["RPG-2019-414 194"]}],"id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010046","name":"University of Essex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UKRI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health, or the Society for the Study of Evolution"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Incompatibilities on the sex chromosomes are important in the evolution of hybrid male sterility, but the evolutionary forces underlying this phenomenon are unclear. House mice (Mus musculus) lineages have provided powerful models for understanding the genetic basis of hybrid male sterility. X chromosome\u2013autosome interactions cause strong incompatibilities in M. musculus F1 hybrids, but variation in sterility phenotypes suggests a more complex genetic basis. In addition, XY chromosome conflict has resulted in rapid expansions of ampliconic genes with dosage-dependent expression that is essential to spermatogenesis. Here, we evaluated the contribution of XY lineage mismatch to male fertility and stage-specific gene expression in hybrid mice. We performed backcrosses between two house mouse subspecies to generate reciprocal Y-introgression strains and used these strains to test the effects of XY mismatch in hybrids. Our transcriptome analyses of sorted spermatid cells revealed widespread overexpression of the X chromosome in sterile F1 hybrids independent of Y chromosome subspecies origin. Thus, postmeiotic overexpression of the X chromosome in sterile F1 mouse hybrids is likely a downstream consequence of disrupted meiotic X-inactivation rather than XY gene copy number imbalance. Y chromosome introgression did result in subfertility phenotypes and disrupted expression of several autosomal genes in mice with an otherwise nonhybrid genomic background, suggesting that Y-linked incompatibilities contribute to reproductive barriers, but likely not as a direct consequence of XY conflict. Collectively, these findings suggest that rapid sex chromosome gene family evolution driven by genomic conflict has not resulted in strong male reproductive barriers between these subspecies of house mice.<\/jats:p>","DOI":"10.1093\/genetics\/iyac151","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T08:51:52Z","timestamp":1664873512000},"source":"Crossref","is-referenced-by-count":7,"title":["The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice"],"prefix":"10.1093","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-2491","authenticated-orcid":false,"given":"Emily E K","family":"Kopania","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of Montana , Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-4360","authenticated-orcid":false,"given":"Eleanor M","family":"Watson","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Essex , Colchester CO4 3SQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C","family":"Rathje","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Kent , Canterbury CT2 7NJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-1167","authenticated-orcid":false,"given":"Benjamin M","family":"Skinner","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Essex , Colchester CO4 3SQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9709-7934","authenticated-orcid":false,"given":"Peter J I","family":"Ellis","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Kent , Canterbury CT2 7NJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-645X","authenticated-orcid":false,"given":"Erica L","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Denver , Denver, CO 80208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-5374","authenticated-orcid":false,"given":"Jeffrey M","family":"Good","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana , Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"issue":"1","key":"2023100402163147600_iyac151-B1","doi-asserted-by":"crossref","first-page":"e1004916","DOI":"10.1371\/journal.pgen.1004916","article-title":"PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of 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