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The cellular communication network factors family of matricellular proteins serve regulatory roles to regulate cell function and are defined by their conserved multimodular organization. Here, we characterize the expression and neuronal requirement for the Drosophila cellular communication network factor family member. Drosophila cellular communication network factor is expressed in the nervous system throughout development including in subsets of monoamine-expressing neurons. Drosophila cellular communication network factor-expressing abdominal ganglion neurons innervate the ovaries and uterus and the loss of Drosophila cellular communication network factor results in reduced female fertility. In addition, Drosophila cellular communication network factor accumulates at the synaptic cleft and is required for neurotransmission at the larval neuromuscular junction. Analyzing the function of the single Drosophila cellular communication network factor family member will enhance our potential to understand how the microenvironment impacts neurotransmitter release in distinct cellular contexts and in response to activity.<\/jats:p>","DOI":"10.1093\/genetics\/iyac190","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T16:52:52Z","timestamp":1672937572000},"source":"Crossref","is-referenced-by-count":3,"title":["The matricellular protein <i>Drosophila<\/i> Cellular Communication Network Factor is required for synaptic transmission and female fertility"],"prefix":"10.1093","volume":"223","author":[{"given":"Elizabeth","family":"Catudio Garrett","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of Montana , Missoula, MT 59812 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M","family":"Bielawski","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana , Missoula, MT 59812 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Ruchti","sequence":"additional","affiliation":[{"name":"Brain Mind Institute, Swiss Federal Institute of Technology (EPFL) , 1015 Lausanne , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis M","family":"Sherer","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana , Missoula, MT 59812 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrayani","family":"Waghmare","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Program in Developmental Biology, Vanderbilt-Ingram Center, Vanderbilt University School of Medicine , Nashville, TN 37232 , 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