{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:09:32Z","timestamp":1791497372606,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014434","name":"Polish National Agency for Academic Exchange","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genome sequencing and genetic mapping of molecular markers have demonstrated nearly complete Y-linkage across much of the guppy (Poecilia reticulata) XY chromosome pair. Predominant Y-linkage of factors controlling visible male-specific coloration traits also suggested that these polymorphisms are sexually antagonistic (SA). However, occasional exchanges with the X are detected, and recombination patterns also appear to differ between natural guppy populations, suggesting ongoing evolution of recombination suppression under selection created by partially sex-linked SA polymorphisms. We used molecular markers to directly estimate genetic maps in sires from 4 guppy populations. The maps are very similar, suggesting that their crossover patterns have not recently changed. Our maps are consistent with population genomic results showing that variants within the terminal 5 Mb of the 26.5 Mb sex chromosome, chromosome 12, are most clearly associated with the maleness factor, albeit incompletely. We also confirmed occasional crossovers proximal to the male-determining region, defining a second, rarely recombining, pseudo-autosomal region, PAR2. This fish species may therefore have no completely male-specific region (MSY) more extensive than the male-determining factor. The positions of the few crossover events suggest a location for the male-determining factor within a physically small repetitive region. A sex-reversed XX male had few crossovers in PAR2, suggesting that this region's low crossover rate depends on the phenotypic, not the genetic, sex. Thus, rare individuals whose phenotypic and genetic sexes differ, and\/or occasional PAR2 crossovers in males can explain the failure to detect fully Y-linked variants.<\/jats:p>","DOI":"10.1093\/genetics\/iyad198","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T12:50:44Z","timestamp":1699879844000},"source":"Crossref","is-referenced-by-count":3,"title":["Has recombination changed during the recent evolution of the guppy Y chromosome?"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-9122","authenticated-orcid":false,"given":"Deborah","family":"Charlesworth","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Institute of Ecology and Evolution, University of Edinburgh , Charlotte Auerbach Road, Edinburgh EH9 3LF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Institute of Ecology and Evolution, University of Edinburgh , Charlotte Auerbach Road, Edinburgh EH9 3LF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bergero","sequence":"additional","affiliation":[{"name":"Scottish Rural Agricultural College, Peter Wilson Building, King\u2019s Buildings , W Mains Rd, Edinburgh EH9 3JG , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Gardner","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Institute of Ecology and Evolution, University of Edinburgh , Charlotte Auerbach Road, Edinburgh EH9 3LF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Keegan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Institute of Ecology and Evolution, University of Edinburgh , Charlotte Auerbach Road, Edinburgh EH9 3LF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lengxob","family":"Yong","sequence":"additional","affiliation":[{"name":"Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter , Penryn TR10 9FE , UK"},{"name":"South Carolina Department of Natural Resources, Marine Resources Research Institute , P.O. Box 12559 Charleston, SC 29422-2559 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Hastings","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Institute of Ecology and Evolution, University of Edinburgh , Charlotte Auerbach Road, Edinburgh EH9 3LF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-8075","authenticated-orcid":false,"given":"Mateusz","family":"Konczal","sequence":"additional","affiliation":[{"name":"Evolutionary Biology Group, Faculty of Biology, Adam Mickiewicz University , 60-614 Pozna\u0144 , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"2","key":"2024091716321676400_iyad198-B1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/molbev\/msaa257","article-title":"Divergence and remarkable diversity of the Y chromosome in guppies","volume":"38","author":"Almeida","year":"2021","journal-title":"Mol Biol Evol."},{"key":"2024091716321676400_iyad198-B2","author":"Andrews","year":"2010"},{"issue":"6","key":"2024091716321676400_iyad198-B3","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/bioinformatics\/btx721","article-title":"PERF: an exhaustive algorithm for ultra-fast and efficient identification of microsatellites from large DNA sequences","volume":"34","author":"Avvaru","year":"2018","journal-title":"Bioinformatics"},{"key":"2024091716321676400_iyad198-B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13100-015-0041-9","article-title":"Repbase update, a database of repetitive elements in eukaryotic genomes","volume":"6","author":"Bao","year":"2015","journal-title":"Mob DNA."},{"issue":"14","key":"2024091716321676400_iyad198-B5","doi-asserted-by":"publisher","first-page":"6924","DOI":"10.1073\/pnas.1818486116","article-title":"Exaggerated heterochiasmy in a fish with sex-linked male coloration polymorphisms","volume":"116","author":"Bergero","year":"2019","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"8","key":"2024091716321676400_iyad198-B6","doi-asserted-by":"publisher","first-page":"e1009704","DOI":"10.1371\/journal.pgen.1009704","article-title":"How did the guppy Y chromosome evolve?","volume":"17","author":"Charlesworth","year":"2021","journal-title":"PLoS Genet."},{"issue":"10","key":"2024091716321676400_iyad198-B7","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1534\/g3.120.401573","article-title":"Locating the sex determining region of linkage group 12 of guppy (Poecilia reticulata)","volume":"10","author":"Charlesworth","year":"2020","journal-title":"G3 (Bethesda)"},{"issue":"2","key":"2024091716321676400_iyad198-B8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0022-5193(75)80082-8","article-title":"Theoretical genetics of Batesian mimicry. II. Evolution of supergenes","volume":"55","author":"Charlesworth","year":"1975","journal-title":"J Theoret Biol"},{"issue":"988","key":"2024091716321676400_iyad198-B9","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1086\/283342","article-title":"A model for the evolution of dioecy and gynodioecy","volume":"112","author":"Charlesworth","year":"1978","journal-title":"Am Nat"},{"issue":"2","key":"2024091716321676400_iyad198-B10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1017\/S0016672300014051","article-title":"Sex differences in fitness and selection for centric fusions between sex-chromosomes and autosomes","volume":"35","author":"Charlesworth","year":"1980","journal-title":"Genet Re"},{"issue":"12","key":"2024091716321676400_iyad198-B11","doi-asserted-by":"publisher","first-page":"3550","DOI":"10.1093\/molbev\/msaa187","article-title":"Using GC content to compare recombination patterns on the sex chromosomes and autosomes of the guppy, Poecilia reticulata, and its close outgroup species","volume":"37","author":"Charlesworth","year":"2020","journal-title":"Mol Biol Evol."},{"issue":"3","key":"2024091716321676400_iyad198-B12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/genetics\/115.3.569","article-title":"Natural selection and Y-linked polymorphism","volume":"115","author":"Clark","year":"1987","journal-title":"Genetics"},{"issue":"2","key":"2024091716321676400_iyad198-B13","doi-asserted-by":"publisher","first-page":"e1010011","DOI":"10.1371\/journal.pgen.1010011","article-title":"Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut","volume":"18","author":"Edvardsen","year":"2022","journal-title":"PLoS Genet."},{"issue":"4","key":"2024091716321676400_iyad198-B14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1469-185X.1931.tb01030.x","article-title":"The evolution of dominance","volume":"6","author":"Fisher","year":"1931","journal-title":"Biol Rev"},{"issue":"17","key":"2024091716321676400_iyad198-B15","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.1073\/pnas.1921046117","article-title":"Repeatmodeler2: automated genomic discovery of transposable element families","volume":"117","author":"Flynn","year":"2020","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"10","key":"2024091716321676400_iyad198-B16","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1093\/gbe\/evaa187","article-title":"Improved reference genome uncovers novel sex-linked regions in the guppy (Poecilia reticulata)","volume":"12","author":"Fraser","year":"2020","journal-title":"Genome Biol Evol."},{"key":"2024091716321676400_iyad198-B17","author":"Garrison","year":"2012"},{"issue":"3","key":"2024091716321676400_iyad198-B18","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/j.1558-5646.2011.01495.x","article-title":"Predation-associated differences in sex-linkage of wild guppy coloration","volume":"66","author":"Gordon","year":"2012","journal-title":"Evolution"},{"issue":"1","key":"2024091716321676400_iyad198-B19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13100-021-00259-7","article-title":"A beginner\u2019s Guide to manual curation of transposable elements","volume":"13","author":"Goubert","year":"2022","journal-title":"Mob DNA"},{"issue":"3","key":"2024091716321676400_iyad198-B20","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2307\/2405461","article-title":"The inheritance of certain color patterns in wild populations of Lebistes reticulatus inTrinidad","volume":"5","author":"Haskins","year":"1951","journal-title":"Evolution"},{"key":"2024091716321676400_iyad198-B21","first-page":"320","volume-title":"Vertebrate Speciation","author":"Haskins","year":"1961"},{"issue":"2","key":"2024091716321676400_iyad198-B22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1558-5646.2011.01448.x","article-title":"The potential for sexually antagonistic polymorphism in different genome regions","volume":"66","author":"Jordan","year":"2012","journal-title":"Evolution"},{"issue":"6","key":"2024091716321676400_iyad198-B23","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2108\/zsj.16.893","article-title":"Linkage analysis and mapping of three sex-linked color pattern genes in the guppy, Poecilia reticulata","volume":"16","author":"Khoo","year":"1999","journal-title":"Zool Sci."},{"issue":"2","key":"2024091716321676400_iyad198-B24","doi-asserted-by":"publisher","first-page":"jkab435","DOI":"10.1093\/g3journal\/jkab435","article-title":"Evolution of the canonical sex chromosomes of the guppy and relatives","volume":"12","author":"Kirkpatrick","year":"2022","journal-title":"G3 (Bethesda)"},{"issue":"2","key":"2024091716321676400_iyad198-B25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1534\/genetics.113.156026","article-title":"Signatures of sex-antagonistic selection on recombining sex chromosomes","volume":"197","author":"Kirkpatrick","year":"2014","journal-title":"Genetics"},{"issue":"1","key":"2024091716321676400_iyad198-B26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/biolinnean\/blad032","article-title":"Repeatability of crossover rate in wild sticklebacks","volume":"140","author":"Kivikoski","year":"2023","journal-title":"Biol J Linn Soc"},{"key":"2024091716321676400_iyad198-B27","doi-asserted-by":"publisher","first-page":"e0169087","DOI":"10.1371\/journal.pone.0169087","article-title":"The genome of the Trinidadian guppy, Poecilia reticulata, and variation in the Guanapo population","volume":"11","author":"K\u00fcnstner","year":"2017","journal-title":"PLoS One"},{"issue":"5441","key":"2024091716321676400_iyad198-B28","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.286.5441.964","article-title":"Four evolutionary strata on the human X chromosome","volume":"286","author":"Lahn","year":"1999","journal-title":"Science"},{"key":"2024091716321676400_iyad198-B29","author":"Li","year":"2013"},{"issue":"6","key":"2024091716321676400_iyad198-B30","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1111\/mec.16355","article-title":"Gene duplication to the Y chromosome in Trinidadian Guppies","volume":"31","author":"Lin","year":"2022","journal-title":"Mol Ecol."},{"issue":"S6","key":"2024091716321676400_iyad198-B31","doi-asserted-by":"publisher","first-page":"S214","DOI":"10.1086\/342898","article-title":"Sex chromosomes and sexual selection in Poeciliid fishes","volume":"160","author":"Lindholm","year":"2002","journal-title":"Am Nat"},{"issue":"2","key":"2024091716321676400_iyad198-B32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1089\/zeb.2014.1000","article-title":"Sex chromosome synapsis and recombination in male guppies","volume":"12","author":"Lisachov","year":"2015","journal-title":"Zebrafish"},{"issue":"16","key":"2024091716321676400_iyad198-B33","doi-asserted-by":"publisher","first-page":"R641","DOI":"10.1016\/S0960-9822(03)00570-0","article-title":"Sex chromosomes: how X-Y recombination stops","volume":"13","author":"Marais","year":"2003","journal-title":"Curr Biol."},{"issue":"1","key":"2024091716321676400_iyad198-B34","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1016\/j.cub.2016.11.002","article-title":"Meiotic recombination: taking the path less traveled","volume":"27","author":"Miller","year":"2017","journal-title":"Curr Biol."},{"issue":"2","key":"2024091716321676400_iyad198-B35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1534\/genetics.119.302232","article-title":"Instability of the pseudoautosomal boundary in house mice","volume":"212","author":"Morgan","year":"2019","journal-title":"Genetics"},{"issue":"1937","key":"2024091716321676400_iyad198-B36","doi-asserted-by":"publisher","first-page":"20201677","DOI":"10.1098\/rspb.2020.1677","article-title":"High-resolution characterization of male ornamentation and re-evaluation of sex linkage in guppies","volume":"287","author":"Morris","year":"2020","journal-title":"Proc Biol Sci"},{"issue":"11","key":"2024091716321676400_iyad198-B37","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1101\/gr.253435.119","article-title":"A chromosome-level assembly of the Atlantic herring genome-detection of a supergene and other signals of selection","volume":"29","author":"Pettersson","year":"2019","journal-title":"Genome Res"},{"issue":"8","key":"2024091716321676400_iyad198-B38","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1111\/j.1558-5646.2011.01314.x","article-title":"Sex-dependent selection differentially shapes genetic variation on and off the guppy Y chromosome","volume":"65","author":"Postma","year":"2011","journal-title":"Evolution"},{"issue":"6642","key":"2024091716321676400_iyad198-B39","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.ade5671","article-title":"Female preference for rare males is maintained by indirect selection in Trinidadian guppies","volume":"380","author":"Potter","year":"2023","journal-title":"Science"},{"issue":"21","key":"2024091716321676400_iyad198-B40","doi-asserted-by":"publisher","first-page":"5524","DOI":"10.1111\/mec.16674","article-title":"Partial sex linkage and linkage disequilibrium on the guppy sex chromosome","volume":"31","author":"Qiu","year":"2022","journal-title":"Mol Ecol."},{"issue":"23","key":"2024091716321676400_iyad198-B41","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1093\/bioinformatics\/btx494","article-title":"Lep-MAP3: robust linkage mapping even for low-coverage whole genome sequencing data","volume":"33","author":"Rastas","year":"2017","journal-title":"Bioinformatics"},{"issue":"4","key":"2024091716321676400_iyad198-B42","doi-asserted-by":"publisher","first-page":"911","DOI":"10.2307\/2408899","article-title":"The accumulation of sexually antagonistic genes as a selective agent promoting the evolution of reduced recombination between primitive sex-chromosomes","volume":"41","author":"Rice","year":"1987","journal-title":"Evolution"},{"issue":"6051","key":"2024091716321676400_iyad198-B43","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/319291a0","article-title":"A gradient of sex linkage in the pseudoautosomal region of the human sex-chromosomes","volume":"319","author":"Rouyer","year":"1986","journal-title":"Nature"},{"issue":"2","key":"2024091716321676400_iyad198-B44","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1086\/704943","article-title":"Sex differences in the recombination landscape","volume":"195","author":"Sardell","year":"2020","journal-title":"Am Nat"},{"issue":"9","key":"2024091716321676400_iyad198-B45","doi-asserted-by":"publisher","first-page":"evac116","DOI":"10.1093\/gbe\/evac116","article-title":"The rattlesnake W chromosome: a GC-rich retroelement refugium with retained gene function across ancient evolutionary strata","volume":"14","author":"Schield","year":"2022","journal-title":"Genome Biol Evol."},{"key":"2024091716321676400_iyad198-B46","first-page":"8","article-title":"The genetic behavlour of a secondary sexual character","volume":"14","author":"Schmidt","year":"1920","journal-title":"Comptes-rendus des travails du Laborotoire Carlsberg"},{"issue":"1","key":"2024091716321676400_iyad198-B47","doi-asserted-by":"publisher","first-page":"5448","DOI":"10.1038\/ncomms6448","article-title":"Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes","volume":"5","author":"Smeds","year":"2014","journal-title":"Nat Commun."},{"issue":"1665","key":"2024091716321676400_iyad198-B48","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1098\/rspb.2008.1930","article-title":"Genetic linkage map of the guppy, Poecilia reticulata, and quantitative trait loci analysis of male size and colour variation","volume":"276","author":"Tripathi","year":"2009","journal-title":"Proc Biol Sci"},{"key":"2024091716321676400_iyad198-B49","first-page":"163","article-title":"Butterfly mimicry: the genetical evolution of an adaptation","volume":"10","author":"Turner","year":"1977","journal-title":"Evol Biol."},{"issue":"4","key":"2024091716321676400_iyad198-B50","doi-asserted-by":"publisher","first-page":"evac040","DOI":"10.1093\/gbe\/evac040","article-title":"High-resolution estimates of crossover and noncrossover recombination from a captive baboon colony","volume":"14","author":"Wall","year":"2022","journal-title":"Genome Biol Evol."},{"issue":"5","key":"2024091716321676400_iyad198-B51","doi-asserted-by":"publisher","first-page":"e1009566","DOI":"10.1371\/journal.pgen.1009566","article-title":"Drainage-structuring of ancestral variation and a common functional pathway shape limited genomic convergence in natural high- and low-predation guppies","volume":"17","author":"Whiting","year":"2021","journal-title":"PLoS Genet."},{"issue":"1","key":"2024091716321676400_iyad198-B52","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/BF03052599","article-title":"The location of eighteen genes in Lebistes reticulatus","volume":"18","author":"Winge","year":"1927","journal-title":"J Genet."},{"issue":"1","key":"2024091716321676400_iyad198-B53","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF03052594","article-title":"On the occurrence of XX males in Lebistes with some remarks on Aida's So called \u2018non-disjunctional males' in Aplocheilus","volume":"23","author":"Winge","year":"1930","journal-title":"J Genet."},{"key":"2024091716321676400_iyad198-B100","first-page":"1","article-title":"The experimental alteration of sex chromosomes into autosomes and vice versa, as illustrated by Lebistes","volume":"21","author":"Winge","year":"1934","journal-title":"C. R. Lab. Carlsberg Physiol"},{"issue":"1","key":"2024091716321676400_iyad198-B54","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/hdy.1947.4","article-title":"Colour inheritance and sex determination in Lebistes","volume":"1","author":"Winge","year":"1947","journal-title":"Heredity (Edinb)."},{"key":"2024091716321676400_iyad198-B55","doi-asserted-by":"publisher","first-page":"14251","DOI":"10.1038\/ncomms14251","article-title":"Convergent recombination suppression suggests a role of sexual conflict in guppy sex chromosome formation","volume":"8","author":"Wright","year":"2017","journal-title":"Nat Commun."},{"issue":"6","key":"2024091716321676400_iyad198-B56","doi-asserted-by":"publisher","first-page":"e1010801","DOI":"10.1371\/journal.pgen.1010801","article-title":"The evolutionary maintenance of ancient recombining sex chromosomes in the ostrich","volume":"19","author":"Yazdi","year":"2023","journal-title":"PLoS Genet."}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyad198\/54022699\/iyad198.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/226\/1\/iyad198\/59152528\/iyad198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/226\/1\/iyad198\/59152528\/iyad198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T12:32:24Z","timestamp":1726576344000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyad198\/7416750"}},"subtitle":[],"editor":[{"given":"C","family":"Peichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,11,13]]},"published-print":{"date-parts":[[2024,1,3]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyad198","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.17.541215","asserted-by":"object"}]},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,11,13]]},"article-number":"iyad198"}}