{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:49:35Z","timestamp":1779320975880,"version":"3.51.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160177"],"award-info":[{"award-number":["32160177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160292"],"award-info":[{"award-number":["82160292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The maternal inheritance of mitochondria is a widely accepted paradigm, and mechanisms that prevent paternal mitochondria transmission to offspring during spermatogenesis and postfertilization have been described. Although certain species do retain paternal mitochondria, the factors affecting paternal mitochondria inheritance in these cases are unclear. More importantly, the evolutionary benefit of retaining paternal mitochondria and their ultimate fate are unknown. Here we show that transplanted exogenous paternal D. yakuba mitochondria can be transmitted to offspring when maternal mitochondria are dysfunctional in D. melanogaster. Furthermore, we show that the preserved paternal mitochondria are functional, and can be stably inherited, such that the proportion of paternal mitochondria increases gradually in subsequent generations. Our work has important implications that paternal mitochondria inheritance should not be overlooked as a genetic phenomenon in evolution, especially when paternal mitochondria are of significant differences from the maternal mitochondria or the maternal mitochondria are functionally abnormal. Our results improve the understanding of mitochondrial inheritance and provide a new model system for its study.<\/jats:p>","DOI":"10.1093\/genetics\/iyae014","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T20:27:47Z","timestamp":1706646467000},"source":"Crossref","is-referenced-by-count":8,"title":["Maternal mitochondrial function affects paternal mitochondrial inheritance in <i>Drosophila<\/i>"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2990-5691","authenticated-orcid":false,"given":"Jinguo","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Basic Medicine, Gannan Medical University , Ganzhou 341000 , China"},{"name":"Key Laboratory of Mitochondrial Medicine, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Health Management, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Gannan Medical University, Ministry of Education , Ganzhou 341000 , China"},{"name":"Key Laboratory of Genetic and Developmental Related Diseases, Gannan Medical University , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Gannan Medical University, Ministry of Education , Ganzhou 341000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"issue":"6059","key":"2024091717051556200_iyae014-B1","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1126\/science.1211878","article-title":"Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission","volume":"334","author":"Al 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