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In the vinegar fly Drosophila melanogaster, the seminal protein sex peptide (SP) decreases the likelihood of female flies remating and causes additional behavioral and physiological changes that promote fertility including increasing egg production. Although SP is only found in the Drosophila genus, its receptor, sex peptide receptor (SPR), is the widely conserved myoinhibitory peptide (MIP) receptor. To test the functional role of SPR in mediating postmating responses in a non-Drosophila dipteran, we generated 2 independent Spr-knockout alleles in the yellow fever mosquito, Aedes aegypti. Although SPR is needed for postmating responses in Drosophila and the cotton bollworm Helicoverpa armigera, Spr mutant Ae. aegypti show completely normal postmating decreases in remating propensity and increases in egg laying. In addition, injection of synthetic SP or accessory gland homogenate from D. melanogaster into virgin female mosquitoes did not elicit these postmating responses. Our results demonstrate that Spr is not required for these canonical postmating responses in Ae. aegypti, indicating that other, as yet unknown, signaling pathways are likely responsible for these behavioral switches in this disease vector.<\/jats:p>","DOI":"10.1093\/genetics\/iyae034","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T14:15:30Z","timestamp":1711721730000},"source":"Crossref","is-referenced-by-count":16,"title":["Sex peptide receptor is not required for refractoriness to remating or induction of egg laying in <i>Aedes aegypti<\/i>"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-2429","authenticated-orcid":false,"given":"I Alexandra","family":"Amaro","sequence":"first","affiliation":[{"name":"Department of Entomology, Cornell University , Ithaca, NY 14853 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot P","family":"Wohl","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Pitcher","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University , Ithaca, NY 14853 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-9356","authenticated-orcid":false,"given":"Catalina","family":"Alfonso-Parra","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University , Ithaca, NY 14853 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-0646","authenticated-orcid":false,"given":"Frank W","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Cornell University , Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"Paige","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Columbia University , New York, NY 10027 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle E H","family":"Helinski","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University , Ithaca, NY 14853 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Columbia University , New York, NY 10027 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University , Ithaca, NY 14853 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-9505","authenticated-orcid":false,"given":"Mariana F","family":"Wolfner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Cornell University , Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-8712","authenticated-orcid":false,"given":"Conor J","family":"McMeniman","sequence":"additional","affiliation":[{"name":"W. 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