{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:40:57Z","timestamp":1770144057440,"version":"3.49.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"EU Operational Program Innovative Economy"},{"DOI":"10.13039\/501100001870","name":"Foundation for Polish Science","doi-asserted-by":"publisher","award":["TEAM\/2010\u20006\/6"],"award-info":[{"award-number":["TEAM\/2010\u20006\/6"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Centre of Poland OPUS","award":["2015\/19\/B\/NZ2\/00201"],"award-info":[{"award-number":["2015\/19\/B\/NZ2\/00201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pentatricopeptide repeat (PPR) proteins bind RNA and are present in mitochondria and chloroplasts of Eukaryota. In fungi, they are responsible for controlling mitochondrial genome expression, mainly on the posttranscriptional level. Candida albicans is a human opportunistic pathogen with a facultative anaerobic metabolism which, unlike the model yeast Saccharomyces cerevisiae, possesses mitochondrially encoded respiratory Complex I (CI) subunits and does not tolerate loss of mtDNA. We characterized the function of 4 PPR proteins of C. albicans that lack orthologs in S. cerevisiae and found that they are required for the expression of mitochondrially encoded CI subunits. We demonstrated that these proteins localize to mitochondria and are essential to maintain the respiratory capacity of cells. Deletion of genes encoding these PPR proteins results in changes in steady-state levels of mitochondrial RNAs and proteins. We demonstrated that C. albicans cells lacking CaPpr4, CaPpr11, and CaPpr13 proteins show no CI assembly, whereas the lack of CaPpr7p results in a decreased CI activity. CaPpr13p is required to maintain the bicistronic NAD4L\u2013NAD5 mRNA, whereas the other 3 PPR proteins are likely involved in translation-related assembly of mitochondrially encoded CI subunits. In addition, we show that CaAep3p, which is an ortholog of ScAep3p, performs the evolutionary conserved function of controlling expression of the ATP8\u2013ATP6 mRNA. We also show that C. albicans cells lacking PPR proteins express a higher level of the inducible alternative oxidase (AOX2) which likely rescues respiratory defects and compensates for oxidative stress.<\/jats:p>","DOI":"10.1093\/genetics\/iyae124","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T23:23:34Z","timestamp":1722295414000},"source":"Crossref","is-referenced-by-count":2,"title":["<i>Candida albicans<\/i> PPR proteins are required for the expression of respiratory Complex I subunits"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-6777","authenticated-orcid":false,"given":"Joanna Maria","family":"Wenda","sequence":"first","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Drzewicka","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Mulica","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-8671","authenticated-orcid":false,"given":"Emmanuel","family":"Tetaud","sequence":"additional","affiliation":[{"name":"IBGC, Univ. Bordeaux, CNRS, UMR 5095 , F-33000, Bordeaux ,","place":["France"]},{"name":"MFP, Univ. Bordeaux, CNRS, UMR 5234 , F-33000, Bordeaux ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Paul","family":"di Rago","sequence":"additional","affiliation":[{"name":"IBGC, Univ. Bordeaux, CNRS, UMR 5095 , F-33000, Bordeaux ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-482X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Golik","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106 ,","place":["Poland"]},{"name":"Polish Academy of Sciences, Institute of Biochemistry and Biophysics , Warsaw 00-901 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-7628","authenticated-orcid":false,"given":"Karolina","family":"\u0141ab\u0119dzka-Dmoch","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"2024121021305114800_iyae124-B1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0079-6603(05)80003-0","article-title":"Function, structure, and biogenesis of mitochondrial ATP synthase","volume":"80","author":"Ackerman","year":"2005","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"issue":"1","key":"2024121021305114800_iyae124-B2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.protis.2018.11.001","article-title":"Alternative type II NAD(P)H dehydrogenases in the mitochondria of protists and fungi","volume":"170","author":"Antos-Krzeminska","year":"2019","journal-title":"Protist"},{"issue":"22","key":"2024121021305114800_iyae124-B3","doi-asserted-by":"publisher","first-page":"13920","DOI":"10.1093\/nar\/gku1132","article-title":"Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation","volume":"42","author":"Baggio","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024121021305114800_iyae124-B4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/emboj\/21.1.43","article-title":"Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome","volume":"21","author":"Barrientos","year":"2002","journal-title":"EMBO J"},{"issue":"11","key":"2024121021305114800_iyae124-B5","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1091\/mbc.E16-11-0775","article-title":"Aep3p-dependent translation of yeast mitochondrial ATP8","volume":"28","author":"Barros","year":"2017","journal-title":"Mol Biol Cell"},{"issue":"4","key":"2024121021305114800_iyae124-B6","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1534\/genetics.104.037473","article-title":"Mitochondrial translation: elongation factor tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast","volume":"169","author":"Chiron","year":"2005","journal-title":"Genetics"},{"key":"2024121021305114800_iyae124-B7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-1-59745-365-3_7","article-title":"Studying mitochondria in an attractive model: Schizosaccharomyces pombe","volume":"372","author":"Chiron","year":"2007","journal-title":"Methods Mol Biol"},{"issue":"3","key":"2024121021305114800_iyae124-B8","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/j.1432-1033.1996.00779.x","article-title":"Computational method to predict mitochondrially imported proteins and their targeting sequences","volume":"241","author":"Claros","year":"1996","journal-title":"Eur J Biochem"},{"issue":"4","key":"2024121021305114800_iyae124-B9","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1104\/pp.114.244616","article-title":"The pentatricopeptide repeat proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 are involved in the splicing of the multipartite nad5 transcript encoding a subunit of mitochondrial Complex I","volume":"165","author":"Colas des Francs-Small","year":"2014","journal-title":"Plant Physiol"},{"issue":"27","key":"2024121021305114800_iyae124-B10","doi-asserted-by":"publisher","first-page":"10352","DOI":"10.1073\/pnas.0601456103","article-title":"A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors","volume":"103","author":"Colot","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2024121021305114800_iyae124-B11","doi-asserted-by":"publisher","first-page":"5729","DOI":"10.1038\/ncomms6729","article-title":"An artificial PPR scaffold for programmable RNA recognition","volume":"5","author":"Coquille","year":"2014","journal-title":"Nat Commun"},{"issue":"2","key":"2024121021305114800_iyae124-B12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/yea.3445","article-title":"Mitochondrial genetics revisited","volume":"37","author":"Dujon","year":"2020","journal-title":"Yeast"},{"issue":"1","key":"2024121021305114800_iyae124-B13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1471-2164-7-98","article-title":"Phylogenomic analysis of the GIY-YIG nuclease superfamily","volume":"7","author":"Dunin-Horkawicz","year":"2006","journal-title":"BMC Genomics"},{"issue":"1","key":"2024121021305114800_iyae124-B14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/iub.2779","article-title":"RNA processing and degradation mechanisms shaping the mitochondrial transcriptome of budding yeasts","volume":"76","author":"Golik","year":"2024","journal-title":"IUBMB Life"},{"issue":"8","key":"2024121021305114800_iyae124-B15","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0300-9084(89)90072-2","article-title":"The second respiratory chain of Candida parapsilosis: a comprehensive study","volume":"71","author":"Guerin","year":"1989","journal-title":"Biochimie"},{"issue":"1","key":"2024121021305114800_iyae124-B16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0005-2728(02)00308-0","article-title":"Characterization of the mitochondrial respiratory pathways in Candida albicans","volume":"1556","author":"Helmerhorst","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"2024121021305114800_iyae124-B17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.mito.2005.04.001","article-title":"The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans","volume":"5","author":"Helmerhorst","year":"2005","journal-title":"Mitochondrion"},{"issue":"9","key":"2024121021305114800_iyae124-B18","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.4161\/rna.25392","article-title":"Yeast PPR proteins, watchdogs of mitochondrial gene expression","volume":"10","author":"Herbert","year":"2013","journal-title":"RNA Biol"},{"issue":"15","key":"2024121021305114800_iyae124-B19","doi-asserted-by":"publisher","first-page":"e2009329118","DOI":"10.1073\/pnas.2009329118","article-title":"The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3\u2032-UTRs of yeast mitochondrial mRNAs","volume":"118","author":"Hillen","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"41","key":"2024121021305114800_iyae124-B20","doi-asserted-by":"publisher","first-page":"37987","DOI":"10.1074\/jbc.M206132200","article-title":"Cbp1 is required for translation of the mitochondrial cytochrome b mRNA of Saccharomyces cerevisiae","volume":"277","author":"Islas-Osuna","year":"2002","journal-title":"J Biol Chem"},{"issue":"7873","key":"2024121021305114800_iyae124-B21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"6","key":"2024121021305114800_iyae124-B22","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.celrep.2015.01.012","article-title":"Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies","volume":"10","author":"Kehrein","year":"2015","journal-title":"Cell Rep"},{"issue":"1","key":"2024121021305114800_iyae124-B23","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1186\/s12864-015-2078-z","article-title":"The transcriptome of Candida albicans mitochondria and the evolution of organellar transcription units in yeasts","volume":"16","author":"Kolondra","year":"2015","journal-title":"BMC Genomics"},{"issue":"6","key":"2024121021305114800_iyae124-B24","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1091\/mbc.E04-02-0126","article-title":"The mitochondrial message-specific mRNA protectors Cbp1 and Pet309 are associated in a high-molecular weight complex","volume":"15","author":"Krause","year":"2004","journal-title":"Mol Biol Cell"},{"issue":"18","key":"2024121021305114800_iyae124-B25","doi-asserted-by":"publisher","first-page":"8029","DOI":"10.1093\/nar\/gkr511","article-title":"A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression","volume":"39","author":"K\u00fchl","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024121021305114800_iyae124-B26","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/nph.14528","article-title":"The mitochondrial pentatricopeptide repeat protein PPR19 is involved in the stabilization of NADH dehydrogenase 1 transcripts and is crucial for mitochondrial function and Arabidopsis thaliana development","volume":"215","author":"Lee","year":"2017","journal-title":"New Phytol"},{"issue":"5","key":"2024121021305114800_iyae124-B27","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1128\/EC.00303-10","article-title":"Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death","volume":"10","author":"Li","year":"2011","journal-title":"Eukaryotic Cell"},{"issue":"10","key":"2024121021305114800_iyae124-B28","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1093\/molbev\/msr120","article-title":"Revisiting the yeast PPR proteins\u2013application of an iterative hidden Markov model algorithm reveals new members of the rapidly evolving family","volume":"28","author":"Lipinski","year":"2011","journal-title":"Mol Biol Evol."},{"issue":"1","key":"2024121021305114800_iyae124-B29","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1038\/s41467-023-40209-w","article-title":"Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence","volume":"14","author":"Liu","year":"2023","journal-title":"Nat Commun"},{"issue":"19","key":"2024121021305114800_iyae124-B30","doi-asserted-by":"publisher","first-page":"fnaa170","DOI":"10.1093\/femsle\/fnaa170","article-title":"Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation","volume":"367","author":"Liu","year":"2020","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"2024121021305114800_iyae124-B31","doi-asserted-by":"publisher","first-page":"100869","DOI":"10.1016\/j.jbc.2021.100869","article-title":"Schizosaccharomyces pombe Ppr10 and mpa1 together mediate mitochondrial translational initiation","volume":"297","author":"Luo","year":"2021","journal-title":"J Biol Chem"},{"key":"2024121021305114800_iyae124-B32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0076-6879(08)02222-2","article-title":"In vivo and in vitro approaches for studying the yeast mitochondrial RNA degradosome complex","volume":"447","author":"Malecki","year":"2008","journal-title":"Meth Enzymol"},{"issue":"2","key":"2024121021305114800_iyae124-B33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"issue":"2","key":"2024121021305114800_iyae124-B34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/s0014-5793(01)03060-5","article-title":"Respiratory chain network in mitochondria of Candida parapsilosis: ADP\/O appraisal of the multiple electron pathways","volume":"508","author":"Milani","year":"2001","journal-title":"FEBS Lett"},{"issue":"7597","key":"2024121021305114800_iyae124-B35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"issue":"1","key":"2024121021305114800_iyae124-B36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev.genet.41.042007.170146","article-title":"Genetics of Candida albicans, a diploid human fungal pathogen","volume":"41","author":"Noble","year":"2007","journal-title":"Annu Rev Genet"},{"issue":"1","key":"2024121021305114800_iyae124-B37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1146\/annurev-biochem-060815-014334","article-title":"Organization and regulation of mitochondrial protein synthesis","volume":"85","author":"Ott","year":"2016","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"2024121021305114800_iyae124-B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01006890","article-title":"The biology of yeast mitochondrial introns","volume":"18","author":"Pel","year":"1993","journal-title":"Mol Biol Rep"},{"issue":"9","key":"2024121021305114800_iyae124-B39","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1261\/rna.074880.120","article-title":"Yeast pentatricopeptide protein Dmr1 (Ccm1) binds a repetitive AU-rich motif in the small subunit mitochondrial ribosomal RNA","volume":"26","author":"Pi\u0105tkowski","year":"2020","journal-title":"RNA"},{"issue":"1","key":"2024121021305114800_iyae124-B40","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1073\/pnas.1012076108","article-title":"Mechanism of RNA stabilization and translational activation by a pentatricopeptide repeat protein","volume":"108","author":"Prikryl","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2024121021305114800_iyae124-B41","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1534\/genetics.110.113969","article-title":"DMR1 (CCM1\/YGR150C) of Saccharomyces cerevisiae encodes an RNA-binding protein from the pentatricopeptide repeat family required for the maintenance of the mitochondrial 15S ribosomal RNA","volume":"184","author":"Puchta","year":"2010","journal-title":"Genetics"},{"issue":"11","key":"2024121021305114800_iyae124-B42","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1111\/pbi.13659","article-title":"OsNBL3, a mitochondrion-localized pentatricopeptide repeat protein, is involved in splicing nad5 intron 4 and its disruption causes lesion mimic phenotype with enhanced resistance to biotic and abiotic stresses","volume":"19","author":"Qiu","year":"2021","journal-title":"Plant Biotechnol J"},{"key":"2024121021305114800_iyae124-B43","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.gene.2004.06.021","article-title":"The SAT1 flipper, an optimized tool for gene disruption in Candida albicans","volume":"341","author":"Reuss","year":"2004","journal-title":"Gene"},{"issue":"13","key":"2024121021305114800_iyae124-B44","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1134\/S0006297914130112","article-title":"Alternative oxidase: distribution, induction, properties, structure, regulation, and functions","volume":"79","author":"Rogov","year":"2014","journal-title":"Biochemistry Mosc"},{"issue":"4","key":"2024121021305114800_iyae124-B45","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat Protoc"},{"issue":"2","key":"2024121021305114800_iyae124-B46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10863-006-9012-7","article-title":"Inhibition of specific electron transport pathways leads to oxidative stress and decreased Candida albicans proliferation","volume":"38","author":"Ruy","year":"2006","journal-title":"J Bioenerg Biomembr."},{"issue":"51","key":"2024121021305114800_iyae124-B47","doi-asserted-by":"publisher","first-page":"49397","DOI":"10.1074\/jbc.M207219200","article-title":"A pathogenic cytochrome b mutation reveals new interactions between subunits of the mitochondrial bc1 complex","volume":"277","author":"Saint-Georges","year":"2002","journal-title":"J Biol Chem"},{"issue":"9","key":"2024121021305114800_iyae124-B48","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.fgb.2011.04.003","article-title":"Milestones in Candida albicans gene manipulation","volume":"48","author":"Samaranayake","year":"2011","journal-title":"Fungal Genet Biol"},{"issue":"7","key":"2024121021305114800_iyae124-B49","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"12","key":"2024121021305114800_iyae124-B50","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.tplants.2008.10.001","article-title":"Pentatricopeptide repeat proteins: a socket set for organelle gene expression","volume":"13","author":"Schmitz-Linneweber","year":"2008","journal-title":"Trends Plant Sci"},{"issue":"12","key":"2024121021305114800_iyae124-B51","doi-asserted-by":"publisher","first-page":"6759","DOI":"10.1093\/nar\/gkaa424","article-title":"The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis","volume":"48","author":"Seshadri","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024121021305114800_iyae124-B52","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1038\/s41467-017-01221-z","article-title":"LRPPRC-mediated folding of the mitochondrial transcriptome","volume":"8","author":"Siira","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"2024121021305114800_iyae124-B53","doi-asserted-by":"publisher","first-page":"e1007976","DOI":"10.1371\/journal.pgen.1007976","article-title":"Mitochondrial proline catabolism activates Ras1\/cAMP\/PKA-induced filamentation in Candida albicans","volume":"15","author":"Silao","year":"2019","journal-title":"PLoS Genet"},{"issue":"6","key":"2024121021305114800_iyae124-B54","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.molcel.2020.07.024","article-title":"Molecular connectivity of mitochondrial gene expression and OXPHOS biogenesis","volume":"79","author":"Singh","year":"2020","journal-title":"Mol Cell"},{"issue":"2","key":"2024121021305114800_iyae124-B55","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0968-0004(99)01520-0","article-title":"The PPR motif\u2014a TPR-related motif prevalent in plant organellar proteins","volume":"25","author":"Small","year":"2000","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"2024121021305114800_iyae124-B56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00294-014-0441-2","article-title":"Two pentatricopeptide repeat domain proteins are required for the synthesis of respiratory complex I","volume":"61","author":"Solotoff","year":"2015","journal-title":"Curr Genet"},{"issue":"6","key":"2024121021305114800_iyae124-B57","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"Spinazzi","year":"2012","journal-title":"Nat Protoc"},{"issue":"3","key":"2024121021305114800_iyae124-B58","doi-asserted-by":"publisher","first-page":"e00300","DOI":"10.1128\/mBio.00300-19","article-title":"Unique, diverged, and conserved mitochondrial functions influencing Candida albicans respiration","volume":"10","author":"Sun","year":"2019","journal-title":"mBio"},{"issue":"3","key":"2024121021305114800_iyae124-B59","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1074\/jbc.M708437200","article-title":"The pentatricopeptide repeats present in Pet309 are necessary for translation but not for stability of the mitochondrial COX1 mRNA in yeast","volume":"283","author":"Tavares-Carre\u00f3n","year":"2008","journal-title":"J Biol Chem"},{"issue":"21","key":"2024121021305114800_iyae124-B60","doi-asserted-by":"publisher","first-page":"11815","DOI":"10.1093\/nar\/gkaa627","article-title":"Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA","volume":"48","author":"Teramoto","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2024121021305114800_iyae124-B61","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2024121021305114800_iyae124-B62","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nprot.2008.137","article-title":"PCR-based gene targeting in Candida albicans","volume":"3","author":"Walther","year":"2008","journal-title":"Nat Protoc"},{"issue":"6","key":"2024121021305114800_iyae124-B63","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1093\/nar\/gkx127","article-title":"The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2024121021305114800_iyae124-B64","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1128\/JB.181.6.1868-1874.1999","article-title":"Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions","volume":"181","author":"Wilson","year":"1999","journal-title":"J Bacteriol."},{"issue":"19","key":"2024121021305114800_iyae124-B65","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1002\/pmic.200800017","article-title":"Features and applications of blue-native and clear-native electrophoresis","volume":"8","author":"Wittig","year":"2008","journal-title":"Proteomics"},{"issue":"4","key":"2024121021305114800_iyae124-B66","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1093\/jac\/dkp273","article-title":"The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility","volume":"64","author":"Yan","year":"2009","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"2024121021305114800_iyae124-B67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat Methods"},{"issue":"7","key":"2024121021305114800_iyae124-B68","doi-asserted-by":"publisher","first-page":"953","DOI":"10.4161\/rna.29780","article-title":"The Pet309 pentatricopeptide repeat motifs mediate efficient binding to the mitochondrial COX1 transcript in yeast","volume":"11","author":"Zamudio-Ochoa","year":"2014","journal-title":"RNA Biol"},{"issue":"1","key":"2024121021305114800_iyae124-B69","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyae124\/58867485\/iyae124.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/228\/2\/iyae124\/60968311\/iyae124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/228\/2\/iyae124\/60968311\/iyae124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T21:54:36Z","timestamp":1733867676000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyae124\/7723236"}},"subtitle":[],"editor":[{"given":"A","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":69,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,7,29]]},"published-print":{"date-parts":[[2024,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyae124","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,7,29]]},"article-number":"iyae124"}}