{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:20:33Z","timestamp":1787008833231,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["5T32GM141848-3"],"award-info":[{"award-number":["5T32GM141848-3"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01GM141422"],"award-info":[{"award-number":["R01GM141422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, few examples directly linking meiotic drive to hybrid sterility. In this study, we report that the Sex-Ratio chromosome of Drosophila pseudoobscura, which causes X-chromosome drive within the USA subspecies, causes near-complete male sterility when it is moved into the genetic background of the Bogota subspecies. In addition, we show that this new form of sterility is genetically distinct from the sterility of F1 hybrid males in crosses between USA males and Bogota females. Our observations provide a tractable study system where noncryptic drive within species is transformed into strong hybrid sterility between very young subspecies.<\/jats:p>","DOI":"10.1093\/genetics\/iyae133","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T16:19:05Z","timestamp":1724861945000},"source":"Crossref","is-referenced-by-count":14,"title":["Transformation of meiotic drive into hybrid sterility in Drosophila"],"prefix":"10.1093","volume":"228","author":[{"given":"Jackson","family":"Bladen","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Utah , Salt Lake City, UT 84112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9489-6439","authenticated-orcid":false,"given":"Hyuck-Jin","family":"Nam","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah , Salt Lake City, UT 84112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Phadnis","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah , Salt Lake City, UT 84112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"issue":"2","key":"2026032801024258000_iyae133-B1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/oxfordjournals.molbev.a025589","article-title":"Molecular evolution of the Sex-Ratio inversion complex in Drosophila pseudoobscura: analysis of the Esterase-5 gene region","volume":"13","author":"Babcock","year":"1996","journal-title":"Mol Biol Evol"},{"key":"2026032801024258000_iyae133-B2","first-page":"9","article-title":"Fruitless experiments with fruit flies: the \u2018sex ratio\u2019 chromosomes of D. pseudoobscura","volume":"58","author":"Beckenbach","year":"1982","journal-title":"Drosoph Inf Serv"},{"issue":"2","key":"2026032801024258000_iyae133-B3","doi-asserted-by":"publisher","first-page":"e1008350","DOI":"10.1371\/journal.pgen.1008350","article-title":"Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency","volume":"16","author":"Bravo N\u00fa\u00f1ez","year":"2020","journal-title":"PLoS Genet"},{"issue":"2","key":"2026032801024258000_iyae133-B4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/genetics\/147.2.635","article-title":"The sex-ratio trait in Drosophila simulans: genetic analysis of distortion and suppression","volume":"147","author":"Cazemajor","year":"1997","journal-title":"Genetics"},{"issue":"1","key":"2026032801024258000_iyae133-B5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1558-5646.1997.tb02412.x","article-title":"Patterns of speciation in Drosophila revisited","volume":"51","author":"Coyne","year":"1997","journal-title":"Evolution"},{"issue":"1","key":"2026032801024258000_iyae133-B6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1601-5223.1974.tb01356.x","article-title":"Genetic analysis of hybrid sterility within the species Drosophila pseudoobscura","volume":"77","author":"Dobzhansky","year":"1974","journal-title":"Hereditas"},{"issue":"1","key":"2026032801024258000_iyae133-B7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/genetics\/48.1.91","article-title":"Genetics of natural populations. 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