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In Caenorhabditis elegans, autophagy participates in diverse processes such as stress resistance, cell fate specification, tissue remodeling, aging, and adaptive immunity. Genetic screens in C. elegans have identified a set of metazoan-specific autophagy genes that form the basis for our molecular understanding of steps unique to the autophagy pathway in multicellular organisms. Suppressor screens have uncovered multiple mechanisms that modulate autophagy activity under physiological conditions. C. elegans also provides a model to investigate how autophagy activity is coordinately controlled at an organismal level. In this chapter, we will discuss the molecular machinery, regulation, and physiological functions of autophagy, and also methods utilized for monitoring autophagy during C. elegans development.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf007","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:48:39Z","timestamp":1743752919000},"source":"Crossref","is-referenced-by-count":11,"title":["Conserved components of the macroautophagy machinery in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"229","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[{"name":"National Laboratory of Biomacromolecules, New Cornerstone Science Laboratory, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101 ,","place":["P.R. China"]},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 ,","place":["P.R. 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