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Previously, we demonstrated that Tudor domain-containing protein 5-like plays an important role in the germline where it promotes male identity. However, Tudor domain-containing protein 5-like is also expressed in both the ovary and testis during later stages of germline development, suggesting that it plays a role in germline differentiation in both sexes. We found that Tudor domain-containing protein 5-like localizes to a potentially novel germline body and plays a role in posttranscriptional gene regulation. Additionally, embryos laid by Tdrd5l-mutant females exhibited reduced viability and displayed dorsal appendage defects suggesting a failure of proper dorsal\u2013ventral patterning. As dorsal\u2013ventral patterning is dependent on gurken (grk), we examined Gurken expression during oogenesis. We observed premature accumulation of Gurken protein in nurse cells indicating that translation is no longer properly repressed during mRNA transport to the oocyte. We also observed increased nurse cell accumulation of the cytoplasmic polyadenylation element binding protein Oo18 RNA-binding protein, a translational activator of grk. Decreasing orb function was able to partially rescue the Tdrd5l-mutant phenotype, and so defects in Orb expression are likely a primary cause of the defects in Tdrd5l mutants. Our data indicate that Tdrd5l is important for translational repression of maternal mRNAs such as orb, and possibly others, following their synthesis in the nurse cells and during their transport to the oocyte.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf024","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T15:20:39Z","timestamp":1739892039000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Tudor domain containing protein 5-like<\/i>\n                    identifies a novel germline body and regulates maternal RNAs during oogenesis in\n                    <i>Drosophila<\/i>"],"prefix":"10.1093","volume":"229","author":[{"given":"Caitlin","family":"Pozmanter","sequence":"first","affiliation":[{"name":"Department of Biology, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Benner","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health , 6 Center Drive, Bldg. 6B Room 3B326, Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney E","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Biology, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison","family":"Curnutte","sequence":"additional","affiliation":[{"name":"Department of Biology, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Emilfork","sequence":"additional","affiliation":[{"name":"Department of Biology, Johns Hopkins University , 3400 N. Charles Street, Baltimore, MD 21218 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Van Doren","sequence":"additional","affiliation":[{"name":"Department of Biology, Johns Hopkins University , 3400 N. 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