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To bridge the gap in our understanding of the link between living in poverty and adverse health outcomes, we performed RNA-sequencing of blood immune cells from 204 participants of the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study in Baltimore, Maryland. We identified 138 genes differentially expressed in association with poverty. Genes differentially expressed were enriched in wound healing and coagulation processes. Of the genes differentially expressed in individuals living in poverty, EEF1DP7 and VIL1 are also associated with hypertension in transcriptome-wide association studies. Our results suggest that living in poverty influences inflammation and the risk for cardiovascular disease through gene expression changes in immune cells.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf072","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T01:56:36Z","timestamp":1744336596000},"source":"Crossref","is-referenced-by-count":3,"title":["Living in poverty is associated with gene expression changes in immune cells"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-755X","authenticated-orcid":false,"given":"Nicole S","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Biology, Morgan State University , Baltimore 21251 ,","place":["USA"]},{"name":"Center for Molecular Medicine and Genetics, Wayne State University , Detroit 48201 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