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Plasma membrane subdomains known as the MCC (membrane compartment of Can1) or eisosomes are important for these processes. MCC\/eisosome domains are furrow-shaped invaginations of the plasma membrane that are about 250\u2005nm long and 50\u2005nm deep. To identify proteins that localize to these domains, a proximity labeling method was used in which the TurboID variant of the BirA biotin ligase was fused to Sur7 and Lsp1, 2 proteins that localize to eisosomes and are important for virulence. This resulted in biotinylation of nearby proteins, permitting their identification. Analysis of 19 candidate proteins by tagging with the green fluorescent protein identified 7 proteins that detectably overlapped with MCC\/eisosomes. Deletion mutant analysis showed that one of these, a poorly studied protein known as Ker1, was important for hyphal growth in liquid culture, invasive growth into agar medium, and resistance to stress caused by copper and cell wall perturbing agents. Altogether, these approaches identified novel MCC\/eisosome proteins and show that TurboID can be applied to better define the molecular mechanisms of C. albicans pathogenesis and aid in discovery of targets for novel therapeutic strategies.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf077","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T18:05:22Z","timestamp":1745863522000},"source":"Crossref","is-referenced-by-count":4,"title":["Proximity labeling identification of plasma membrane eisosome proteins in <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-7065","authenticated-orcid":false,"given":"Carla E","family":"Lanze","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-6413","authenticated-orcid":false,"given":"John D","family":"Haley","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 ,","place":["USA"]},{"name":"Biological Mass Spectrometry Shared Resource, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-4086","authenticated-orcid":false,"given":"James B","family":"Konopka","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University , Stony Brook, NY 11794 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"7","key":"2025060408323314400_iyaf077-B1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/nsmb.1829","article-title":"A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking","volume":"17","author":"Aguilar","year":"2010","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"2025060408323314400_iyaf077-B2","doi-asserted-by":"publisher","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The gene ontology knowledgebase in 2023","volume":"224","author":"Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"issue":"12","key":"2025060408323314400_iyaf077-B3","doi-asserted-by":"publisher","first-page":"5214","DOI":"10.1091\/mbc.e08-05-0479","article-title":"The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans","volume":"19","author":"Alvarez","year":"2008","journal-title":"Mol Biol Cell"},{"issue":"4","key":"2025060408323314400_iyaf077-B4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1091\/mbc.E19-04-0218","article-title":"Plasma membrane tension regulates eisosome structure and function","volume":"31","author":"Appadurai","year":"2020","journal-title":"Mol Biol Cell"},{"key":"2025060408323314400_iyaf077-B5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18546.1","article-title":"Recent advances in understanding Candida albicans hyphal growth","volume":"8","author":"Arkowitz","year":"2019","journal-title":"F1000Res"},{"issue":"1","key":"2025060408323314400_iyaf077-B6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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