{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:07:38Z","timestamp":1791972458608,"version":"4.3.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R01 HD115159"],"award-info":[{"award-number":["R01 HD115159"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["DP2 NS132107"],"award-info":[{"award-number":["DP2 NS132107"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Alabama at Birmingham FCIDD McNulty Scientist Award"},{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A.J.M. Generation of original pIGLET14a line","award":["NIH\/NHLBI 1K99HL168148-01"],"award-info":[{"award-number":["NIH\/NHLBI 1K99HL168148-01"]}]},{"DOI":"10.13039\/100016193","name":"the University of Colorado School of Medicine, Anschutz Medical Campus","doi-asserted-by":"publisher","award":["NIH\/NHLBI 1R01HL168097-01A1"],"award-info":[{"award-number":["NIH\/NHLBI 1R01HL168097-01A1"]}],"id":[{"id":"10.13039\/100016193","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Children\u2019s Hospital Colorado Foundation;"},{"name":"The Helen and Arthur E. Johnson Chair For The Cardiac Research Director"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Gal4\/UAS system is used across model organisms to overexpress target genes in precise cell types and relies on generating transgenic Gal4 driver lines. In zebrafish, the Tg(elavl3:KalTA4) (HuC) Gal4 line drives robust expression in neurons. We observed an increased prevalence of swim bladder defects in Tg(elavl3:KalTA4) zebrafish larvae compared to wildtype siblings, which prompted us to investigate whether transgenic larvae display additional neurobehavioral phenotypes. Tg(elavl3:KalTA4) larvae showed alterations in brain activity, brain morphology, and behavior, including increased hindbrain size and reduced activity of the cerebellum. Bulk RNA-seq analysis revealed dysregulation of the transcriptome and suggested an increased ratio of neuronal progenitor cells compared to differentiated neurons. To understand whether these phenotypes derive from Gal4 toxicity or from positional effects related to transgenesis, we used economical low-pass whole genome sequencing to map the Tol2-mediated insertion site to chromosome eight. Reduced expression of the neighboring gene gadd45ga, a known cell cycle regulator, is consistent with increased proliferation and suggests a role for positional effects. Challenges with creating alternative pan-neuronal lines include the length of the elavl3 promoter (over 8\u2005kb) and random insertion using traditional transgenesis methods. To facilitate the generation of alternative lines, we cloned five neuronal promoters (atp6v0cb, smaller elavl3, rtn1a, sncb, and stmn1b) ranging from 1.7 to 4.3\u2005kb and created KalTA4 lines using Tol2 and the phiC31 integrase-based pIGLET system. Our study highlights the importance of using appropriate genetic controls and interrogating potential positional effects in new transgenic lines.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf195","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:01:31Z","timestamp":1758348091000},"source":"Crossref","is-referenced-by-count":6,"title":["Genetic context of transgene insertion can influence neurodevelopment in zebrafish"],"prefix":"10.1093","volume":"231","author":[{"given":"Anna J","family":"Moyer","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Chrabasz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia K","family":"Barcus","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E S","family":"Capps","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-0983","authenticated-orcid":false,"given":"Robert L","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-2576","authenticated-orcid":false,"given":"Christian","family":"Mosimann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-4148","authenticated-orcid":false,"given":"Summer B","family":"Thyme","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biotechnology, The University of Massachusetts Chan Medical School , Worcester, MA 01605 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"2025112406271371000_iyaf195-B1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ydbio.2011.01.002","article-title":"Transgenerational analysis of transcriptional silencing in zebrafish","volume":"352","author":"Akitake","year":"2011","journal-title":"Dev Biol"},{"key":"2025112406271371000_iyaf195-B2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/zeb.2015.1086","article-title":"Intersectional gene expression in zebrafish using the split kalta4 system","volume":"12","author":"Almeida","year":"2015","journal-title":"Zebrafish"},{"key":"2025112406271371000_iyaf195-B3","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1073\/pnas.0704963105","article-title":"Genetic dissection of neural circuits by tol2 transposon-mediated gal4 gene and enhancer trapping in zebrafish","volume":"105","author":"Asakawa","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025112406271371000_iyaf195-B4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3389\/fncir.2012.00110","article-title":"Brain selective transgene expression in zebrafish using an nrse derived motif","volume":"6","author":"Bergeron","year":"2012","journal-title":"Front Neural Circuits"},{"key":"2025112406271371000_iyaf195-B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/zeb.2022.0043","article-title":"Zebrafish sox2 is required for the swim bladder inflation by controlling the swim-up behavior","volume":"20","author":"Cao","year":"2023","journal-title":"Zebrafish"},{"key":"2025112406271371000_iyaf195-B6","doi-asserted-by":"publisher","first-page":"e2402557122","DOI":"10.1073\/pnas.2402557122","article-title":"Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations","volume":"122","author":"Capps","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025112406271371000_iyaf195-B7","doi-asserted-by":"publisher","first-page":"e1005934","DOI":"10.1371\/journal.pgen.1005934","article-title":"Pcp signaling between migrating neurons and their planar-polarized neuroepithelial environment controls filopodial dynamics and directional migration","volume":"12","author":"Davey","year":"2016","journal-title":"PLoS Genet"},{"key":"2025112406271371000_iyaf195-B8","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ydbio.2007.01.033","article-title":"Transactivation from gal4-vp16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish","volume":"304","author":"Davison","year":"2007","journal-title":"Dev Biol"},{"key":"2025112406271371000_iyaf195-B9","doi-asserted-by":"publisher","first-page":"e1006780","DOI":"10.1371\/journal.pgen.1006780","article-title":"Genetic compensation: a phenomenon in search of mechanisms","volume":"13","author":"El-Brolosy","year":"2017","journal-title":"PLoS Genet"},{"key":"2025112406271371000_iyaf195-B10","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/334721a0","article-title":"Negative effect of the transcriptional activator gal4","volume":"334","author":"Gill","year":"1988","journal-title":"Nature"},{"key":"2025112406271371000_iyaf195-B11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/0092-8674(85)90336-8","article-title":"Specific DNA binding of gal4, a positive regulatory protein of yeast","volume":"40","author":"Giniger","year":"1985","journal-title":"Cell"},{"key":"2025112406271371000_iyaf195-B12","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1182\/blood.2020008229","article-title":"Gadd45g acts as a novel tumor suppressor, and its activation suggests new combination regimens for the treatment of aml","volume":"138","author":"Guo","year":"2021","journal-title":"Blood"},{"key":"2025112406271371000_iyaf195-B13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1023\/A:1026055612227","article-title":"Cardiac expression of gal4 causes cardiomyopathy in a dose-dependent manner","volume":"24","author":"Habets","year":"2003","journal-title":"J Muscle Res Cell Motil"},{"key":"2025112406271371000_iyaf195-B14","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/s41467-024-54763-4","article-title":"The widely used ucp1-cre transgene elicits complex developmental and metabolic phenotypes","volume":"16","author":"Halurkar","year":"2025","journal-title":"Nat Commun"},{"key":"2025112406271371000_iyaf195-B15","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1152\/jn.00576.2003","article-title":"Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator","volume":"90","author":"Higashijima","year":"2003","journal-title":"J Neurophysiol"},{"key":"2025112406271371000_iyaf195-B16","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2007.01.040","article-title":"Comprehensive maps of drosophila higher olfactory centers: spatially segregated fruit and pheromone representation","volume":"128","author":"Jefferis","year":"2007","journal-title":"Cell"},{"key":"2025112406271371000_iyaf195-B17","doi-asserted-by":"publisher","first-page":"606900","DOI":"10.3389\/fnbeh.2020.606900","article-title":"A customizable low-cost system for massively parallel zebrafish behavioral phenotyping","volume":"14","author":"Joo","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"2025112406271371000_iyaf195-B18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3389\/fncir.2014.00138","article-title":"Prolonged, brain-wide expression of nuclear-localized gcamp3 for functional circuit mapping","volume":"8","author":"Kim","year":"2014","journal-title":"Front Neural Circuits"},{"key":"2025112406271371000_iyaf195-B19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1006\/dbio.2001.0242","article-title":"Tracing transgene expression in living zebrafish embryos","volume":"233","author":"K\u00f6ster","year":"2001","journal-title":"Dev Biol"},{"key":"2025112406271371000_iyaf195-B20","first-page":"43","article-title":"Gal4 causes developmental defects and apoptosis when expressed in the developing eye of drosophila melanogaster","volume":"2","author":"Kramer","year":"2003","journal-title":"Genet Mol Res"},{"key":"2025112406271371000_iyaf195-B21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-1-0716-3401-1_11","article-title":"Genetic identification of neural circuits essential for active avoidance fear conditioning in adult zebrafish","volume":"2707","author":"Lal","year":"2024","journal-title":"Methods Mol Biol"},{"key":"2025112406271371000_iyaf195-B22","doi-asserted-by":"publisher","first-page":"eadn6603","DOI":"10.1126\/sciadv.adn6603","article-title":"Piglet: safe harbor landing sites for reproducible and efficient transgenesis in zebrafish","volume":"10","author":"Lalonde","year":"2024","journal-title":"Sci Adv"},{"key":"2025112406271371000_iyaf195-B23","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fncir.2015.00078","article-title":"A 3d searchable database of transgenic zebrafish gal4 and cre lines for functional neuroanatomy studies","volume":"9","author":"Marquart","year":"2015","journal-title":"Front Neural Circuits"},{"key":"2025112406271371000_iyaf195-B24","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41596-022-00752-0","article-title":"Optimized single-nucleus transcriptional profiling by combinatorial indexing","volume":"18","author":"Martin","year":"2023","journal-title":"Nat Protoc"},{"key":"2025112406271371000_iyaf195-B25","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/dvdy.23989","article-title":"Site-directed zebrafish transgenesis into single landing sites with the phic31 integrase system","volume":"242","author":"Mosimann","year":"2013","journal-title":"Dev Dyn"},{"key":"2025112406271371000_iyaf195-B26","first-page":"PRJNA1217389","article-title":"Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4)","author":"Moyer","year":"2025","journal-title":"Sequence Read Archive (SRA)"},{"key":"2025112406271371000_iyaf195-B27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1242\/dev.009050","article-title":"Insertional mutagenesis by the tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: Tcf7 and synembryn-like","volume":"135","author":"Nagayoshi","year":"2008","journal-title":"Development"},{"key":"2025112406271371000_iyaf195-B28","doi-asserted-by":"publisher","first-page":"108054","DOI":"10.1016\/j.celrep.2020.108054","article-title":"The zebrafish dorsolateral habenula is required for updating learned behaviors","volume":"32","author":"Palumbo","year":"2020","journal-title":"Cell Rep"},{"key":"2025112406271371000_iyaf195-B29","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1101\/gr.277278.122","article-title":"A single-cell transcriptome atlas of the maturing zebrafish telencephalon","volume":"33","author":"Pandey","year":"2023","journal-title":"Genome Res"},{"key":"2025112406271371000_iyaf195-B30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/dbio.2000.9898","article-title":"Analysis of upstream elements in the huc promoter leads to the establishment of transgenic zebrafish with fluorescent neurons","volume":"227","author":"Park","year":"2000","journal-title":"Dev Biol"},{"key":"2025112406271371000_iyaf195-B31","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.neuron.2020.09.023","article-title":"Emergence of neuronal diversity during vertebrate brain development","volume":"108","author":"Raj","year":"2020","journal-title":"Neuron"},{"key":"2025112406271371000_iyaf195-B32","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nmeth.3581","article-title":"Whole-brain activity mapping onto a zebrafish brain atlas","volume":"12","author":"Randlett","year":"2015","journal-title":"Nat Methods"},{"key":"2025112406271371000_iyaf195-B33","doi-asserted-by":"publisher","first-page":"12692","DOI":"10.1038\/s41598-020-69423-y","article-title":"Evaluation of qpcr reference genes in gh-overexpressing transgenic zebrafish (danio rerio)","volume":"10","author":"Rassier","year":"2020","journal-title":"Sci Rep"},{"key":"2025112406271371000_iyaf195-B34","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1242\/dev.100347","article-title":"Targeted transgene integration overcomes variability of position effects in zebrafish","volume":"141","author":"Roberts","year":"2014","journal-title":"Development"},{"key":"2025112406271371000_iyaf195-B35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/335563a0","article-title":"Gal4-vp16 is an unusually potent transcriptional activator","volume":"335","author":"Sadowski","year":"1988","journal-title":"Nature"},{"key":"2025112406271371000_iyaf195-B36","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1242\/dev.128.7.1099","article-title":"An instructive function for notch in promoting gliogenesis in the zebrafish retina","volume":"128","author":"Scheer","year":"2001","journal-title":"Development"},{"key":"2025112406271371000_iyaf195-B37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nmeth1033","article-title":"Targeting neural circuitry in zebrafish using gal4 enhancer trapping","volume":"4","author":"Scott","year":"2007","journal-title":"Nat Methods"},{"key":"2025112406271371000_iyaf195-B38","doi-asserted-by":"publisher","first-page":"e0281609","DOI":"10.1371\/journal.pone.0281609","article-title":"Multivariate analysis of variegated expression in neurons: a strategy for unbiased localization of gene function to candidate brain regions in larval zebrafish","volume":"18","author":"Shoenhard","year":"2023","journal-title":"PLoS One"},{"key":"2025112406271371000_iyaf195-B39","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1016\/j.devcel.2023.11.001","article-title":"Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development","volume":"58","author":"Sur","year":"2023","journal-title":"Dev Cell"},{"key":"2025112406271371000_iyaf195-B40","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/dvdy.20720","article-title":"Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis","volume":"235","author":"Takamiya","year":"2006","journal-title":"Dev Dyn"},{"key":"2025112406271371000_iyaf195-B41","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.cell.2019.01.048","article-title":"Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions","volume":"177","author":"Thyme","year":"2019","journal-title":"Cell"},{"key":"2025112406271371000_iyaf195-B42","article-title":"Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4)","volume":"GSE288241","author":"Thyme","year":"2025","journal-title":"Gene Expression Omnibus (GEO)"},{"key":"2025112406271371000_iyaf195-B45","article-title":"Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4) - addition of a second elavl3:KalTA4 bulk RNA-sequencing dataset","author":"Thyme","year":"2025","journal-title":"Gene Expression Omnibus"},{"key":"2025112406271371000_iyaf195-B43","first-page":"GSE288775","article-title":"Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4)","author":"Thyme","year":"2025","journal-title":"ene Expression Omnibus (GEO)"},{"key":"2025112406271371000_iyaf195-B44","unstructured":"Thyme SB . 2025d. Neurobehavioral phenotypes in the pan-neuronal GAL4 zebrafish line Tg(elavl3:KalTA4). Zenodo. 10.5281\/zenodo.16762444."},{"key":"2025112406271371000_iyaf195-B46","doi-asserted-by":"publisher","first-page":"4.22.1","DOI":"10.1002\/0471142727.mb0422s107","article-title":"Preparation of single-cell rna-seq libraries for next generation sequencing","volume":"107","author":"Trombetta","year":"2014","journal-title":"Curr Protoc Mol Biol"},{"key":"2025112406271371000_iyaf195-B47","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/jcp.10140","article-title":"Gadd45b and gadd45g are cdc2\/cyclinb1 kinase inhibitors with a role in s and g2\/m cell cycle checkpoints induced by genotoxic stress","volume":"192","author":"Vairapandi","year":"2002","journal-title":"J Cell Physiol"},{"key":"2025112406271371000_iyaf195-B48","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.245635","article-title":"A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line","volume":"226","author":"Venuto","year":"2023","journal-title":"J Exp Biol"},{"key":"2025112406271371000_iyaf195-B49","doi-asserted-by":"publisher","first-page":"113348","DOI":"10.1016\/j.celrep.2023.113348","article-title":"An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep"},{"key":"2025112406271371000_iyaf195-B50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72825","article-title":"Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants","volume":"11","author":"White","year":"2022","journal-title":"Elife"},{"key":"2025112406271371000_iyaf195-B51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1741-7007-10-93","article-title":"Silencer-delimited transgenesis: Nrse\/re1 sequences promote neural-specific transgene expression in a nrsf\/rest-dependent manner","volume":"10","author":"Xie","year":"2012","journal-title":"BMC Biol"},{"key":"2025112406271371000_iyaf195-B52","doi-asserted-by":"publisher","first-page":"6442","DOI":"10.1158\/1078-0432.CCR-05-0267","article-title":"The stress-responsive gene gadd45g is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors","volume":"11","author":"Ying","year":"2005","journal-title":"Clin Cancer Res"},{"key":"2025112406271371000_iyaf195-B53","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/hep.26628","article-title":"Growth arrest and DNA damage 45g down-regulation contributes to Janus kinase\/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma","volume":"59","author":"Zhang","year":"2014","journal-title":"Hepatology"},{"key":"2025112406271371000_iyaf195-B54","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1038\/s41467-024-47297-2","article-title":"Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyaf195\/64303191\/iyaf195.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/231\/3\/iyaf195\/64303191\/iyaf195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/231\/3\/iyaf195\/64303191\/iyaf195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:27:20Z","timestamp":1763983640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyaf195\/8256811"}},"subtitle":[],"editor":[{"given":"G","family":"Downes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":54,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,17]]},"published-print":{"date-parts":[[2025,11,12]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyaf195","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,9,17]]},"article-number":"iyaf195"}}