{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:30:12Z","timestamp":1763983812027,"version":"3.45.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chair","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI127375"],"award-info":[{"award-number":["R01AI127375"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chair","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Microbial Genomics & Infectious Disease"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the significant global health burden posed by Candida albicans, a large proportion of its genome has yet to be characterized. While insights from model yeasts have historically provided valuable functional clues, their utility is approaching its limits given the increasing evidence of divergence across fungal species. The C. albicans inner kinetochore is a poorly characterized cellular structure. In particular, the constitutive centromere-associated network has only four previously known components, likely due to DNA sequence divergence between orthologous complex members from Saccharomyces cerevisiae or Schizosaccharomyces pombe. Here, we leveraged a structure-focused approach to identify seven components of the C. albicans constitutive centromere-associated network. Phenotypic characterization of loss-of-function mutants confirmed important roles in fitness and cell cycle progression for various kinetochore subunits. Furthermore, protein interactions identified through affinity purification-mass spectrometry as well as confocal microscopy confirmed the interaction and localization of these predicted kinetochore components with known kinetochore members. Overall, this work significantly enhances our understanding of a key cellular structure in C. albicans and underscores the urgent need for pathogen-specific research to better understand its unique biological mechanisms.<\/jats:p>","DOI":"10.1093\/genetics\/iyaf201","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T02:04:08Z","timestamp":1758333848000},"source":"Crossref","is-referenced-by-count":0,"title":["Identification and characterization of components of the\n                    <i>Candida albicans<\/i>\n                    inner kinetochore"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8756-5612","authenticated-orcid":false,"given":"Emily H","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ci","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health , Toronto, Ontario M5G 1X5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra J","family":"Wong","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health , Toronto, Ontario M5G 1X5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla","family":"Nathwani","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-3372","authenticated-orcid":false,"given":"Hansen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Claude","family":"Gingras","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]},{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health , Toronto, Ontario M5G 1X5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-0110","authenticated-orcid":false,"given":"Leah E","family":"Cowen","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"2025112406271525600_iyaf201-B1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/j.1365-2958.2005.04727.x","article-title":"Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans","volume":"57","author":"Bachewich","year":"2005","journal-title":"Mol Microbiol."},{"key":"2025112406271525600_iyaf201-B2","doi-asserted-by":"publisher","first-page":"e1009071","DOI":"10.1371\/journal.pgen.1009071","article-title":"The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits","volume":"16","author":"Balachandra","year":"2020","journal-title":"PLoS Genet."},{"key":"2025112406271525600_iyaf201-B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/jof4010039","article-title":"FungiDB: an integrated bioinformatic resource for fungi and oomycetes","volume":"4","author":"Basenko","year":"2018","journal-title":"J Fungi (Basel, Switzerland)"},{"key":"2025112406271525600_iyaf201-B4","doi-asserted-by":"publisher","first-page":"14877","DOI":"10.1073\/pnas.0606958103","article-title":"Formation of functional centromeric chromatin is specified epigenetically in Candida albicans","volume":"103","author":"Baum","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B5","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.mib.2006.10.007","article-title":"Morphogenesis and cell cycle progression in Candida albicans","volume":"9","author":"Berman","year":"2006","journal-title":"Curr Opin Microbiol."},{"key":"2025112406271525600_iyaf201-B6","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1371\/journal.pgen.0010001","article-title":"A human-curated annotation of the Candida albicans genome","volume":"1","author":"Braun","year":"2005","journal-title":"PLoS Genet."},{"key":"2025112406271525600_iyaf201-B7","doi-asserted-by":"publisher","first-page":"e00842-22","DOI":"10.1128\/mbio.00842-22","article-title":"Genomic diversity across Candida auris clinical isolates shapes rapid development of antifungal resistance in vitro and in vivo","volume":"13","author":"Burrack","year":"2022","journal-title":"mBio"},{"key":"2025112406271525600_iyaf201-B8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2025112406271525600_iyaf201-B9","doi-asserted-by":"publisher","first-page":"5048","DOI":"10.1073\/pnas.0401416101","article-title":"Tyrosol is a quorum-sensing molecule in Candida albicans","volume":"101","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B10","doi-asserted-by":"publisher","first-page":"D363","DOI":"10.1093\/nar\/gkj123","article-title":"OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups","volume":"34","author":"Chen","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2025112406271525600_iyaf201-B11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cell.2019.01.033","article-title":"Global genetic networks and the genotype-to-phenotype relationship","volume":"177","author":"Costanzo","year":"2019","journal-title":"Cell"},{"key":"2025112406271525600_iyaf201-B12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.copbio.2010.11.001","article-title":"Charting the genetic interaction map of a cell","volume":"22","author":"Costanzo","year":"2011","journal-title":"Curr Opin Biotechnol."},{"key":"2025112406271525600_iyaf201-B13","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.2217\/fmb.15.79","article-title":"The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis","volume":"10","author":"Cota","year":"2015","journal-title":"Future Microbiol."},{"key":"2025112406271525600_iyaf201-B14","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1021\/pr049882h","article-title":"Open source system for analyzing, validating, and storing protein identification data","volume":"3","author":"Craig","year":"2004","journal-title":"J Proteome Res."},{"key":"2025112406271525600_iyaf201-B15","doi-asserted-by":"publisher","first-page":"eadg7480","DOI":"10.1126\/sciadv.adg7480","article-title":"Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere","volume":"9","author":"Dendooven","year":"2023","journal-title":"Sci Adv."},{"key":"2025112406271525600_iyaf201-B16","doi-asserted-by":"publisher","first-page":"e268","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis."},{"key":"2025112406271525600_iyaf201-B17","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1021\/acs.jproteome.2c00624","article-title":"Trans-proteomic pipeline: robust mass spectrometry-based proteomics data analysis suite","volume":"22","author":"Deutsch","year":"2023","journal-title":"J Proteome Res."},{"key":"2025112406271525600_iyaf201-B18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1080\/19491034.2022.2115246","article-title":"Cell cycle control of kinetochore assembly","volume":"13","author":"Dong","year":"2022","journal-title":"Nucleus"},{"key":"2025112406271525600_iyaf201-B19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/pmic.201200439","article-title":"Comet: an open-source MS\/MS sequence database search tool","volume":"13","author":"Eng","year":"2013","journal-title":"Proteomics"},{"key":"2025112406271525600_iyaf201-B20","doi-asserted-by":"publisher","first-page":"6497","DOI":"10.1038\/s41467-021-26850-3","article-title":"Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets","volume":"12","author":"Fu","year":"2021","journal-title":"Nat Commun."},{"key":"2025112406271525600_iyaf201-B21","doi-asserted-by":"publisher","first-page":"14706","DOI":"10.1073\/pnas.0706985104","article-title":"Centromere identity is specified by a single centromeric nucleosome in budding yeast","volume":"104","author":"Furuyama","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B22","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/nrg929","article-title":"The origin and evolution of model organisms","volume":"3","author":"Hedges","year":"2002","journal-title":"Nat Rev Genet."},{"key":"2025112406271525600_iyaf201-B23","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.1073\/pnas.0401648101","article-title":"The diploid genome sequence of Candida albicans","volume":"101","author":"Jones","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B24","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2025112406271525600_iyaf201-B25","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nature02424","article-title":"Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae","volume":"428","author":"Kellis","year":"2004","journal-title":"Nature"},{"key":"2025112406271525600_iyaf201-B26","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/35089568","article-title":"Evolutionary conservation between budding yeast and human kinetochores","volume":"2","author":"Kitagawa","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025112406271525600_iyaf201-B27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nmeth.4330","article-title":"ProHits-viz: a suite of web tools for visualizing interaction proteomics data","volume":"14","author":"Knight","year":"2017","journal-title":"Nat Methods."},{"key":"2025112406271525600_iyaf201-B28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/pro.3289","article-title":"PDBsum: structural summaries of PDB entries","volume":"27","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"key":"2025112406271525600_iyaf201-B29","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1101\/gr.1224503","article-title":"OrthoMCL: identification of ortholog groups for eukaryotic genomes","volume":"13","author":"Li","year":"2003","journal-title":"Genome Res."},{"key":"2025112406271525600_iyaf201-B30","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/s41589-023-01349-8","article-title":"Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii","volume":"19","author":"Liu","year":"2023","journal-title":"Nat Chem Biol."},{"key":"2025112406271525600_iyaf201-B31","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1073\/pnas.0712255105","article-title":"Defining genetic interaction","volume":"105","author":"Mani","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B32","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/s0092-86740081602-5","article-title":"Cse4p is a component of the core centromere of Saccharomyces cerevisiae","volume":"94","author":"Meluh","year":"1998","journal-title":"Cell"},{"key":"2025112406271525600_iyaf201-B33","doi-asserted-by":"publisher","first-page":"R23","DOI":"10.1186\/gb-2006-7-3-r23","article-title":"Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins","volume":"7","author":"Meraldi","year":"2006","journal-title":"Genome Biol."},{"key":"2025112406271525600_iyaf201-B34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00438-007-0263-8","article-title":"Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity","volume":"278","author":"Mishra","year":"2007","journal-title":"Mol Genet Genomics."},{"key":"2025112406271525600_iyaf201-B35","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1128\/EC.3.5.1111-1123.2004","article-title":"Msn2- and msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans","volume":"3","author":"Nicholls","year":"2004","journal-title":"Eukaryot Cell."},{"key":"2025112406271525600_iyaf201-B36","doi-asserted-by":"publisher","first-page":"6741","DOI":"10.1038\/ncomms7741","article-title":"Global analysis of fungal morphology exposes mechanisms of host cell escape","volume":"6","author":"O\u2019Meara","year":"2015","journal-title":"Nat Commun."},{"key":"2025112406271525600_iyaf201-B37","doi-asserted-by":"publisher","first-page":"e01245-20","DOI":"10.1128\/mSphere.01245-20","article-title":"DeORFanizing Candida albicans genes using coexpression","volume":"6","author":"O\u2019Meara","year":"2021","journal-title":"mSphere"},{"key":"2025112406271525600_iyaf201-B38","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1101\/gad.14.7.783","article-title":"Distinct protein interaction domains and protein spreading in a complex centromere","volume":"14","author":"Partridge","year":"2000","journal-title":"Genes Dev."},{"key":"2025112406271525600_iyaf201-B39","doi-asserted-by":"publisher","first-page":"D418","DOI":"10.1093\/nar\/gkac993","article-title":"InterPro in 2022","volume":"51","author":"Paysan-Lafosse","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2025112406271525600_iyaf201-B40","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18%253C3551::AID-ELPS3551%253E3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"Perkins","year":"1999","journal-title":"Electrophoresis"},{"key":"2025112406271525600_iyaf201-B41","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1093\/genetics\/141.3.903","article-title":"Evolutionary origin of nonuniversal cug(ser) Codon in some Candida Species as inferred from a molecular phylogeny","volume":"141","author":"Pesole","year":"1995","journal-title":"Genetics"},{"key":"2025112406271525600_iyaf201-B42","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.4161\/cc.4.10.2106","article-title":"Spindle checkpoint maintenance requires Ame1 and Okp1","volume":"4(10)","author":"Pot","year":"2005","journal-title":"Cell Cycle (Georgetown, Tex.)"},{"key":"2025112406271525600_iyaf201-B43","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10555-013-9436\u20136","article-title":"Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos","volume":"32","author":"Potapova","year":"2013","journal-title":"Cancer Metastasis Rev."},{"key":"2025112406271525600_iyaf201-B44","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1093\/bioinformatics\/btq572","article-title":"Pre-calculated protein structure alignments at the RCSB PDB website","volume":"26","author":"Prli\u0107","year":"2010","journal-title":"Bioinformatics"},{"key":"2025112406271525600_iyaf201-B45","doi-asserted-by":"publisher","first-page":"baac011","DOI":"10.1093\/database\/baac011","article-title":"A review on antimicrobial peptides databases and the computational tools","volume":"2022","author":"Ramazi","year":"2022","journal-title":"Database"},{"key":"2025112406271525600_iyaf201-B46","doi-asserted-by":"publisher","first-page":"R522","DOI":"10.1016\/j.cub.2025.01.063","article-title":"Candida","volume":"35","author":"Robbins","year":"2025","journal-title":"Curr Biol."},{"key":"2025112406271525600_iyaf201-B47","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1365-2958.2003.03697.x","article-title":"Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery","volume":"50","author":"Roemer","year":"2003","journal-title":"Mol Microbiol."},{"key":"2025112406271525600_iyaf201-B48","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1365-2958.2011.07558.x","article-title":"Camtw1, a member of the evolutionarily conserved Mis12 kinetochore protein family, is required for efficient inner kinetochore assembly in the pathogenic yeast Candida albicans","volume":"80","author":"Roy","year":"2011","journal-title":"Mol Microbiol."},{"key":"2025112406271525600_iyaf201-B49","doi-asserted-by":"publisher","first-page":"11374","DOI":"10.1073\/pnas.0404318101","article-title":"Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique","volume":"101","author":"Sanyal","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2025112406271525600_iyaf201-B50","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.15252\/embj.201796636","article-title":"Molecular basis for inner kinetochore configuration through RWD domain\u2013peptide interactions","volume":"36","author":"Schmitzberger","year":"2017","journal-title":"EMBO J."},{"key":"2025112406271525600_iyaf201-B51","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1126\/science.1128242","article-title":"Aneuploidy and isochromosome formation in drug-resistant Candida albicans","volume":"313(5785)","author":"Selmecki","year":"2006","journal-title":"Science (New York, N.Y.)"},{"key":"2025112406271525600_iyaf201-B52","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/j.1365-2958.2008.06176.x","article-title":"An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1","volume":"68","author":"Selmecki","year":"2008","journal-title":"Mol Microbiol."},{"key":"2025112406271525600_iyaf201-B53","doi-asserted-by":"publisher","first-page":"D592","DOI":"10.1093\/nar\/gkw924","article-title":"The Candida genome database (CGD): incorporation of assembly 22, systematic identifiers and visualization of high throughput sequencing data","volume":"45","author":"Skrzypek","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2025112406271525600_iyaf201-B54","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/nar\/26.1.320","article-title":"Pfam: multiple sequence alignments and HMM-profiles of protein domains","volume":"26","author":"Sonnhammer","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"2025112406271525600_iyaf201-B55","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41467-020-20161-9","article-title":"Bridgin connects the outer kinetochore to centromeric chromatin","volume":"12","author":"Sridhar","year":"2021","journal-title":"Nat Commun."},{"key":"2025112406271525600_iyaf201-B56","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1126\/science.288.5474.2215","article-title":"Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast","volume":"288","author":"Takahashi","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"2025112406271525600_iyaf201-B57","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jprot.2013.10.023","article-title":"SAINTexpress: improvements and additional features in significance analysis of interactome software","volume":"100","author":"Teo","year":"2014","journal-title":"J Proteomics."},{"key":"2025112406271525600_iyaf201-B58","doi-asserted-by":"publisher","first-page":"e1002661","DOI":"10.1371\/journal.pgen.1002661","article-title":"A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans","volume":"8","author":"Thakur","year":"2012","journal-title":"PLoS Genet."},{"key":"2025112406271525600_iyaf201-B59","doi-asserted-by":"publisher","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"The UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2025112406271525600_iyaf201-B60","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/gb-2007-8-3-r31","article-title":"Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database","volume":"8","author":"Tung","year":"2007","journal-title":"Genome Biol."},{"key":"2025112406271525600_iyaf201-B61","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.15252\/embr.201744102","article-title":"Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics","volume":"18","author":"van Hooff","year":"2017","journal-title":"EMBO Rep."},{"key":"2025112406271525600_iyaf201-B62","doi-asserted-by":"publisher","first-page":"e202209096","DOI":"10.1083\/jcb.202209096","article-title":"Unraveling the kinetochore nanostructure in Schizosaccharomyces pombe using multi-color SMLM imaging","volume":"222","author":"Virant","year":"2023","journal-title":"J Cell Biol."},{"key":"2025112406271525600_iyaf201-B63","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1128\/JB.183.1.46-54.2001","article-title":"Divergence of eukaryotic secretory components: the Candida albicans homolog of the Saccharomyces cerevisiae Sec20 protein is N-terminally truncated, and its levels determine antifungal drug resistance and growth","volume":"183","author":"Weber","year":"2001","journal-title":"J Bacteriol."},{"key":"2025112406271525600_iyaf201-B64","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41467-018-08248-w","article-title":"Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus","volume":"10","author":"Whitesell","year":"2019","journal-title":"Nat Commun."},{"issue":"8","key":"2025112406271525600_iyaf201-B65","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.celrep.2024.114601","article-title":"Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions","volume":"43","author":"Xiong","year":"2024","journal-title":"Cell Rep."},{"key":"2025112406271525600_iyaf201-B66","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1093\/nar\/gki524","article-title":"TM-align: a protein structure alignment algorithm based on the TM-score","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyaf201\/64322255\/iyaf201.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/231\/3\/iyaf201\/64322255\/iyaf201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/231\/3\/iyaf201\/64322255\/iyaf201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:27:22Z","timestamp":1763983642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyaf201\/8258207"}},"subtitle":[],"editor":[{"given":"J","family":"Kronstad","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,19]]},"published-print":{"date-parts":[[2025,11,12]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyaf201","relation":{},"ISSN":["1943-2631"],"issn-type":[{"type":"electronic","value":"1943-2631"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,9,19]]},"article-number":"iyaf201"}}