{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:21:55Z","timestamp":1775323315311,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ramalingaswami Re-entry Fellowship","award":["BT\/RLF\/Re-entry\/50\/2020"],"award-info":[{"award-number":["BT\/RLF\/Re-entry\/50\/2020"]}]},{"name":"Har-Gobind Khorana-Innovative Young Biotechnologist Fellowship","award":["HRD-17011\/2\/2023-HRD-DBT"],"award-info":[{"award-number":["HRD-17011\/2\/2023-HRD-DBT"]}]},{"name":"Department of Biotechnology, India; Anusandhan National Research Foundation (ANRF) Core Research Grant","award":["CRG\/2023\/001136"],"award-info":[{"award-number":["CRG\/2023\/001136"]}]},{"name":"STARS","award":["MoE-STARS\/STARS-2\/2023-0116"],"award-info":[{"award-number":["MoE-STARS\/STARS-2\/2023-0116"]}]},{"name":"Ministry of Education, India; Research Grant","award":["37\/1741\/23\/EMR-II"],"award-info":[{"award-number":["37\/1741\/23\/EMR-II"]}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific & Industrial Research (CSIR), India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011652","name":"IISER Mohali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cellular redox homeostasis depends on a finely tuned balance between oxidizing and reducing conditions, and disturbances in this balance lead to oxidative or reductive stress. While oxidative stress and its pathological outcomes are well studied, the molecular mechanisms underlying cellular responses to reductive stress remain poorly understood. Using Caenorhabditis elegans as a model, we investigate thiol reductive stress induced by dithiothreitol (DTT) and uncover a critical protective role for the hypoxia response pathway. We identify RHY-1, a membrane-associated acyltransferase and known negative regulator of the hypoxia-inducible factor HIF-1, as essential for survival under thiol reductive stress. Notably, rhy-1 is a direct transcriptional target of HIF-1, and overexpression of rhy-1 fully rescues the sensitivity of hif-1 loss-of-function mutants to DTT. We demonstrate that RHY-1 functions in an autoinhibitory feedback loop, where elevated RHY-1 levels suppress activation of the hypoxia response pathway even during reductive stress. Together, our findings establish RHY-1 as both a regulatory and effector component of the hypoxia response pathway that mediates cellular protection against thiol reductive stress.<\/jats:p>","DOI":"10.1093\/genetics\/iyag018","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:59:57Z","timestamp":1769108397000},"source":"Crossref","is-referenced-by-count":0,"title":["Protection from thiol reductive stress through an autoinhibitory hypoxia response pathway in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-7683","authenticated-orcid":false,"family":"Ravi","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Indian Institute of Science Education and Research , Mohali, Punjab 140306 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