{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:37:23Z","timestamp":1783651043585,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM118127"],"award-info":[{"award-number":["1R35GM118127"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5T32GM007092-45"],"award-info":[{"award-number":["5T32GM007092-45"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1F31AG074637"],"award-info":[{"award-number":["1F31AG074637"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Failures in chromosome segregation during meiosis result in aneuploid gametes and are the leading cause of miscarriage. The position and number of crossovers, genetic exchanges between homologous chromosomes, are essential to their accurate disjunction in meiosis. Previous research analyzing nondisjunction of acro- and telocentric chromosomes in human and Drosophila has identified altered positioning and number of crossovers that differs between meiosis I and meiosis II nondisjunction. Limited data from positioning in chromosomes that segregated normally in metacentric trisomies has suggested discrepancies between the behavior of these chromosomes and the acro\/telocentrics in nondisjunction, which warrants further investigation. Here, we employ whole-genome sequencing to study spontaneous meiotic nondisjunction of the metacentric chromosome 2 in Drosophila melanogaster. Several patterns of recombination may differentially impact telo- versus metacentric chromosomes: lack of a crossover, distal crossovers, and proximal crossovers. We find that unlike meiotic nondisjunction of the Drosophila X chromosome, nondisjunction of chromosome 2 is not associated with dramatic changes in crossover landscape, but is associated with reduced recombination. Differences in the proportions of NDJ events with altered recombination patterns between chromosomes X and 2 suggest that abnormal crossover positions disparately affect chromosomes with different shapes. Taken together, these findings highlight that the underlying triggers of meiotic nondisjunction are chromosome-specific.<\/jats:p>","DOI":"10.1093\/genetics\/iyag076","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:59:03Z","timestamp":1774382343000},"source":"Crossref","is-referenced-by-count":1,"title":["Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction"],"prefix":"10.1093","volume":"233","author":[{"given":"Carolyn A","family":"Turcotte","sequence":"first","affiliation":[{"name":"Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-677X","authenticated-orcid":false,"given":"Jeff","family":"Sekelsky","sequence":"additional","affiliation":[{"name":"Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]},{"name":"Department of Biology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"2026050609305728400_iyag076-B1","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","article-title":"The genome sequence of Drosophila melanogaster","volume":"287","author":"Adams","year":"2000","journal-title":"Science"},{"key":"2026050609305728400_iyag076-B2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/genetics\/71.2.255","article-title":"Genetic analysis of sex chromosomal meiotic mutants in Drosophila melanogaster","volume":"71","author":"Baker","year":"1972","journal-title":"Genetics"},{"key":"2026050609305728400_iyag076-B3","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/hmg\/7.4.661","article-title":"Non-disjunction of chromosome 18","volume":"7","author":"Bugge","year":"1998","journal-title":"Hum Mol Genet"},{"key":"2026050609305728400_iyag076-B4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/pd.1123","article-title":"A comparison of maternal age, sex ratio and associated major anomalies among fetal trisomy 18 cases with different cell division of error","volume":"25","author":"Chen","year":"2005","journal-title":"Prenat Diagn"},{"key":"2026050609305728400_iyag076-B5","doi-asserted-by":"publisher","first-page":"e1002905","DOI":"10.1371\/journal.pgen.1002905","article-title":"The many landscapes of recombination in Drosophila melanogaster","volume":"8","author":"Comeron","year":"2012","journal-title":"PLoS Genet"},{"key":"2026050609305728400_iyag076-B6","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1016\/j.cub.2018.07.004","article-title":"Local inversion heterozygosity alters recombination throughout the genome","volume":"28","author":"Crown","year":"2018","journal-title":"Curr Biol"},{"key":"2026050609305728400_iyag076-B7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1508\/cytologia.3.169","article-title":"The origin and behavior of chiasmata, II. 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