{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:16:37Z","timestamp":1778076997450,"version":"3.51.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than nonrepetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while variation at other noncoding loci may affect complex traits, possibly by altering transcription factor occupancy of nearby binding sites. Accordingly, some STRs are inferred to be under purifying selection, regardless of their instability. One or more \u201cinterruptions\u201d, or bases that disrupt the locus's canonical repeat, significantly decrease an STR's mutability. For example, the onset of Huntington's Disease, a neurodegenerative disorder associated with somatic expansions of a trinucleotide coding STR, is delayed in individuals whose inherited alleles contain interruptions. Thus, interruptions that decrease mutation rate at some coding loci may broadly protect against deleterious phenotypes associated with locus instability. However, interruptions may themselves be deleterious at constrained loci, particularly at noncoding loci in gene regulatory elements, possibly disrupting the formation of secondary structures key to their function. We therefore hypothesized that the frequency of interruptions could depend on a locus's functional importance\u2013at constrained loci, the fitness effects of expansions but also interruptions could be more deleterious than at neutral loci. To test this hypothesis, we examined the distribution of interruptions at \u223c650,000 autosomal STRs. In the \u223c2,500 3- or 6bp-motif coding STRs, we find that synonymous interruption density increases with purifying selection on the gene, while the opposite is true for missense-causing interruptions. In contrast, noncoding STRs in gene regulatory elements harbor fewer interruptions than elements that are unassociated with gene regulation and thus more likely to be evolving neutrally. Our findings indicate that the abundance of interruptions may be partially explained at coding STRs by the benefit of lower instability, whereas maintaining a core stretch of uninterrupted repeat may be key to the function of regulatory noncoding STRs, outweighing the benefits of stability.<\/jats:p>","DOI":"10.1093\/genetics\/iyag080","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:35:19Z","timestamp":1774427719000},"source":"Crossref","is-referenced-by-count":0,"title":["The selective dynamics of interruptions at short tandem repeats"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3310-6349","authenticated-orcid":false,"given":"Michael E","family":"Goldberg","sequence":"first","affiliation":[{"name":"Department of Human Genetics, University of Utah , 15 N 2030 E, Salt Lake City, UT 84112 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-6270","authenticated-orcid":false,"given":"Harriet","family":"Dashnow","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Utah , 15 N 2030 E, Salt Lake City, UT 84112 ,","place":["United States"]},{"name":"Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus , 1890 N. Revere Court, Aurora, CO 80045 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-2523","authenticated-orcid":false,"given":"Kelley","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington , 3720 15th Ave NE, Seattle, WA 98195 ,","place":["United States"]},{"name":"Computational Biology Division, Fred Hutchinson Cancer Research Center , 1100 Fairview Ave N, Seattle, WA 98109 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R","family":"Quinlan","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Utah , 15 N 2030 E, Salt Lake City, UT 84112 ,","place":["United 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