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Using the testes of Drosophila melanogaster as a proven model for investigating these processes, we identified a polycistronic locus from which 2 non-coding transcripts, miR-317 and the long non-coding RNA Peony, are produced, with alternative polyadenylation implicated in regulation of their differential expression levels. We report here that each transcript has a distinct role in Drosophila testes; the absence of miR-317 leads to the emergence of germ-cell tumors in developing flies, and the increased expression of Peony results in the disruption of the muscle sheath covering the testis. We also show that miR-317 deficiency increases Notch signaling activity in somatic cyst cells, upregulates multiple predicted targets of miR-317, and drives germline tumorigenesis. Our findings establish miR-317 as a tumor suppressor controlling Notch signaling strength and uncover alternative polyadenylation as an unrecognized mechanism governing miRNA expression.<\/jats:p>","DOI":"10.1093\/genetics\/iyag141","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:47:52Z","timestamp":1780512472000},"source":"Crossref","is-referenced-by-count":0,"title":["A single non-coding RNA locus produces small and long regulatory RNAs with distinct biological functions"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-3368","authenticated-orcid":false,"given":"Travis D","family":"Carney","sequence":"first","affiliation":[{"name":"Institute of Cell Biochemistry, Hannover Medical School , Carl-Neuberg-Strasse 1, 30625 Hannover ,","place":["Germany"]},{"name":"Mount Desert Island Biological Laboratory , 159 Old Bar Harbor Road, Bar Harbor, ME 04609 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-0345","authenticated-orcid":false,"given":"Halyna R","family":"Shcherbata","sequence":"additional","affiliation":[{"name":"Institute of Cell Biochemistry, Hannover Medical School , Carl-Neuberg-Strasse 1, 30625 Hannover ,","place":["Germany"]},{"name":"Mount Desert Island Biological Laboratory , 159 Old Bar Harbor Road, Bar Harbor, ME 04609 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026080509272918200_iyag141-B1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.156315","article-title":"Direct control of somatic stem cell proliferation factors by the Drosophila testis stem cell 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