{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:13:09Z","timestamp":1788340389144,"version":"build-2803163510"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["GM129266"],"award-info":[{"award-number":["GM129266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Bithorax Complex (BX-C) homeobox proteins specify segmental identities along the anterior\u2013posterior axis during embryogenesis in Drosophila. Differential expression of the BX-C genes abd-A (abdominal-A) and Abd-B (Abdominal-B) distinguishes abdominal from thoracic adipocytes, but the mechanisms underlying this heterogeneity remain unknown. Here, we identify cis-regulatory elements (CREs) and DNA-binding proteins that regulate abdomen-specific expression of abd-A and Abd-B in the larval fat body. Fine-mapping analyses identified a 627-bp CRE within the Abd-B locus and an approximately 6-kb CRE within the abd-A locus that are sufficient to drive region-specific expression. Yeast one-hybrid screening and functional analyses revealed that Lola (Longitudinals lacking), Lolal (Lola like), and Cg (Combgap) repress Abd-B expression, whereas Prg (Piragua) and Svp (Seven up) activate Abd-B transcription. We further show that lola and prg are repressed by Abd-B, whereas lolal and svp are activated by Abd-B, forming a feedback regulatory network. Wnt signaling modulates this network by promoting lola and lolal expression and repressing svp. CUT&amp;RUN (Cleavage Under Targets &amp; Release Using Nuclease) analyses identified dTCF\/Pangolin occupancy at the lola, lolal, and svp loci and Abd-B occupancy at the lola and lolal loci, suggesting that a subset of these interactions is direct. Together, these findings define a gene regulatory network that controls Abd-B expression in the larval fat body and provide a molecular mechanism for establishing adipocyte heterogeneity along the anterior\u2013posterior axis.<\/jats:p>","DOI":"10.1093\/genetics\/iyag183","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:50:29Z","timestamp":1784191829000},"source":"Crossref","is-referenced-by-count":0,"title":["Developmental patterning of adipose tissue by\n                    <i>abd-A<\/i>\n                    and\n                    <i>Abd-B<\/i>\n                    homeotic genes in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-5818","authenticated-orcid":false,"given":"Rajitha-Udakara-Sampath","family":"Hemba-Waduge","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9644-5099","authenticated-orcid":false,"given":"Mengmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-5335","authenticated-orcid":false,"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Lewis-Sigler Institute of Integrative Genomics, Princeton University , Princeton, NJ 08540 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Budslick","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-4169","authenticated-orcid":false,"given":"Sarah E","family":"Bondos","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center, Texas A&M University , College Station, TX 77843 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-9481","authenticated-orcid":false,"given":"Keith A","family":"Maggert","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of Arizona , Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-4336","authenticated-orcid":false,"given":"Jun-Yuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026090204122788700_iyag183-B1","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1002\/j.1460-2075.1985.tb03838.x","article-title":"The distribution of ultrabithorax transcripts in Drosophila embryos","volume":"4","author":"Akam","year":"1985","journal-title":"EMBO J"},{"key":"2026090204122788700_iyag183-B2","doi-asserted-by":"publisher","first-page":"e54074","DOI":"10.7554\/eLife.54074","article-title":"A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord","volume":"9","author":"Allen","year":"2020","journal-title":"Elife"},{"key":"2026090204122788700_iyag183-B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.devcel.2013.11.024","article-title":"Hox proteins mediate developmental and environmental control of autophagy","volume":"28","author":"Banreti","year":"2014","journal-title":"Dev Cell"},{"key":"2026090204122788700_iyag183-B4","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1101\/gad.8.14.1664","article-title":"The POZ domain: a conserved protein-protein interaction motif","volume":"8","author":"Bardwell","year":"1994","journal-title":"Genes Dev"},{"key":"2026090204122788700_iyag183-B5","first-page":"920","article-title":"Elimination of false positives that arise in using the two-hybrid system","volume":"14","author":"Bartel","year":"1993","journal-title":"Biotechniques"},{"key":"2026090204122788700_iyag183-B6","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.ydbio.2007.01.029","article-title":"The axon guidance gene lola is required for programmed cell death in the Drosophila ovary","volume":"304","author":"Bass","year":"2007","journal-title":"Dev Biol"},{"key":"2026090204122788700_iyag183-B7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/313545a0","article-title":"Segmental distribution of bithorax complex proteins during Drosophila development","volume":"313","author":"Beachy","year":"1985","journal-title":"Nature"},{"key":"2026090204122788700_iyag183-B8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-4419-6673-5_3","article-title":"Maintenance of Hox gene expression patterns","volume":"689","author":"Beck","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"2026090204122788700_iyag183-B9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1242\/dev.121.1.225","article-title":"The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination","volume":"121","author":"Begemann","year":"1995","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B10","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1534\/genetics.117.300157","article-title":"Wingless signaling: a genetic journey from morphogenesis to metastasis","volume":"208","author":"Bejsovec","year":"2018","journal-title":"Genetics"},{"key":"2026090204122788700_iyag183-B11","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1534\/genetics.120.303708","article-title":"Molecular elssons from the Drosophila Bithorax Complex","volume":"216","author":"Bender","year":"2020","journal-title":"Genetics"},{"key":"2026090204122788700_iyag183-B12","doi-asserted-by":"publisher","first-page":"5311","DOI":"10.1242\/dev.070946","article-title":"Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development","volume":"138","author":"Benito-Sipos","year":"2011","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B13","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1242\/dev.080549","article-title":"The developmental origins of adipose tissue","volume":"140","author":"Berry","year":"2013","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/yea.320070609","article-title":"A family of low and high copy replicative, integrative and single-stranded S. cerevisiae\/E. coli shuttle vectors","volume":"7","author":"Bonneaud","year":"1991","journal-title":"Yeast"},{"key":"2026090204122788700_iyag183-B15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/jcp.10210","article-title":"HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis","volume":"194","author":"Cantile","year":"2003","journal-title":"J Cell Physiol"},{"key":"2026090204122788700_iyag183-B16","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1002\/j.1460-2075.1990.tb07876.x","article-title":"The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the abdominal-B domain","volume":"9","author":"Celniker","year":"1990","journal-title":"EMBO J"},{"key":"2026090204122788700_iyag183-B17","doi-asserted-by":"publisher","first-page":"dev165753","DOI":"10.1242\/dev.165753","article-title":"Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust","volume":"145","author":"Choi","year":"2018","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B18","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1042\/BJ20060375","article-title":"Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2","volume":"398","author":"Choi","year":"2006","journal-title":"Biochem J"},{"key":"2026090204122788700_iyag183-B19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1080\/21623945.2017.1372871","article-title":"Fifty shades of white: understanding heterogeneity in white adipose stem cells","volume":"6","author":"Cleal","year":"2017","journal-title":"Adipocyte"},{"key":"2026090204122788700_iyag183-B20","doi-asserted-by":"publisher","first-page":"e0311751","DOI":"10.1371\/journal.pone.0311751","article-title":"Depot-specific mRNA expression programs in human adipocytes suggest physiological specialization via distinct developmental programs","volume":"19","author":"Clemons","year":"2024","journal-title":"PLoS One"},{"key":"2026090204122788700_iyag183-B21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/bfgp\/elm002","article-title":"Functional analysis of the role of POK transcriptional repressors","volume":"6","author":"Costoya","year":"2007","journal-title":"Brief Funct Genomic Proteomic"},{"key":"2026090204122788700_iyag183-B22","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1242\/dev.129.6.1317","article-title":"Lola regulates midline crossing of CNS axons in Drosophila","volume":"129","author":"Crowner","year":"2002","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1242\/dev.108.2.323","article-title":"Expression of abdominal-B homeoproteins in Drosophila embryos","volume":"108","author":"Delorenzi","year":"1990","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B24","doi-asserted-by":"publisher","first-page":"e1009812","DOI":"10.1371\/journal.pgen.1009812","article-title":"Patterning with clocks and genetic cascades: segmentation and regionalization of vertebrate versus insect body plans","volume":"17","author":"Diaz-Cuadros","year":"2021","journal-title":"PLoS Genet"},{"key":"2026090204122788700_iyag183-B25","first-page":"1","volume-title":"Behavioral neurogenetics. Neuromethods","author":"Duckhorn","year":"2022"},{"key":"2026090204122788700_iyag183-B26","doi-asserted-by":"publisher","first-page":"jcs241943","DOI":"10.1242\/jcs.241943","article-title":"Role of a versatile peptide motif controlling Hox nuclear export and autophagy in the Drosophila fat body","volume":"133","author":"Duffraisse","year":"2020","journal-title":"J Cell Sci"},{"key":"2026090204122788700_iyag183-B27","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1002\/j.1460-2075.1991.tb08058.x","article-title":"Optimal DNA sequence recognition by the ultrabithorax homeodomain of Drosophila","volume":"10","author":"Ekker","year":"1991","journal-title":"EMBO J"},{"key":"2026090204122788700_iyag183-B28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1242\/dev.128.3.331","article-title":"The Hox gene abdominal-B antagonizes appendage development in the genital disc of Drosophila","volume":"128","author":"Estrada","year":"2001","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B29","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nmeth.1356","article-title":"G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila","volume":"6","author":"Evans","year":"2009","journal-title":"Nat Methods"},{"key":"2026090204122788700_iyag183-B30","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1128\/MCB.23.4.1181-1195.2003","article-title":"Batman interacts with polycomb and trithorax group genes and encodes a BTB\/POZ protein that is included in a complex containing GAGA factor","volume":"23","author":"Faucheux","year":"2003","journal-title":"Mol Cell Biol"},{"key":"2026090204122788700_iyag183-B31","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1101\/gr.2659105","article-title":"Protein interaction mapping: a Drosophila case study","volume":"15","author":"Formstecher","year":"2005","journal-title":"Genome Res"},{"key":"2026090204122788700_iyag183-B32","doi-asserted-by":"publisher","first-page":"e1006700","DOI":"10.1371\/journal.pgen.1006700","article-title":"Probing the canonicity of the Wnt\/Wingless signaling pathway","volume":"13","author":"Franz","year":"2017","journal-title":"PLoS Genet"},{"key":"2026090204122788700_iyag183-B33","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/ng0797-277","article-title":"Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens","volume":"16","author":"Fromont-Racine","year":"1997","journal-title":"Nat Genet"},{"key":"2026090204122788700_iyag183-B34","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0070-2153(09)88002-2","article-title":"Evolution of the Hox gene complex from an evolutionary ground state","volume":"88","author":"Gehring","year":"2009","journal-title":"Curr Top Dev Biol"},{"key":"2026090204122788700_iyag183-B35","doi-asserted-by":"publisher","first-page":"6676","DOI":"10.1073\/pnas.0601752103","article-title":"Evidence for a role of developmental genes in the origin of obesity and body fat distribution","volume":"103","author":"Gesta","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090204122788700_iyag183-B36","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","article-title":"Developmental origin of fat: tracking obesity to its source","volume":"131","author":"Gesta","year":"2007","journal-title":"Cell"},{"key":"2026090204122788700_iyag183-B37","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1002\/imt2.43","article-title":"Complex heatmap visualization","volume":"1","author":"Gu","year":"2022","journal-title":"iMeta"},{"key":"2026090204122788700_iyag183-B38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fncel.2014.00096","article-title":"Hox gene regulation in the central nervous system of Drosophila","volume":"8","author":"Gummalla","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"2026090204122788700_iyag183-B39","doi-asserted-by":"publisher","first-page":"718308","DOI":"10.3389\/fcell.2021.718308","article-title":"Homeotic genes: clustering, modularity, and diversity","volume":"9","author":"Hajirnis","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026090204122788700_iyag183-B40","doi-asserted-by":"publisher","first-page":"e46181","DOI":"10.7554\/eLife.46181","article-title":"In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer","volume":"8","author":"He","year":"2019","journal-title":"Elife"},{"key":"2026090204122788700_iyag183-B41","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s44319-025-00625-z","article-title":"Adipocyte heterogeneity regulated by the bithorax complex-Wnt signaling crosstalk in Drosophila","volume":"27","author":"Hemba-Waduge","year":"2026","journal-title":"EMBO Rep"},{"key":"2026090204122788700_iyag183-B42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-031-97035-1_4","article-title":"Transcriptional regulation of lipid metabolism by Wnt signaling and Hox protein cues","volume":"1482","author":"Hemba-Waduge","year":"2025","journal-title":"Adv Exp Med Biol"},{"key":"2026090204122788700_iyag183-B43","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s44319-025-00625-z","article-title":"Adipocyte heterogeneity regulated by the Bithorax Complex-Wnt signaling crosstalk in Drosophila","volume":"27","author":"Hemba-Waduge","year":"2026","journal-title":"EMBO Reports"},{"key":"2026090204122788700_iyag183-B44","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2026090204122788700_iyag183-B45","doi-asserted-by":"publisher","first-page":"D908","DOI":"10.1093\/nar\/gkaa936","article-title":"FlyRNAi.org\u2014the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update","volume":"49","author":"Hu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026090204122788700_iyag183-B46","doi-asserted-by":"publisher","first-page":"dev192476","DOI":"10.1242\/dev.192476","article-title":"Hox genes in development and beyond","volume":"150","author":"Hubert","year":"2023","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1741-7007-9-5","article-title":"Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assay","volume":"9","author":"Hudry","year":"2011","journal-title":"BMC Biol"},{"key":"2026090204122788700_iyag183-B48","doi-asserted-by":"publisher","first-page":"e10820","DOI":"10.1371\/journal.pone.0010820","article-title":"Improving Hox protein classification across the major model organisms","volume":"5","author":"Hueber","year":"2010","journal-title":"PLoS One"},{"key":"2026090204122788700_iyag183-B49","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00018-010-0536-y","article-title":"The gap gene network","volume":"68","author":"Jaeger","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2026090204122788700_iyag183-B50","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","article-title":"A GAL4-driver line resource for Drosophila neurobiology","volume":"2","author":"Jenett","year":"2012","journal-title":"Cell Rep"},{"key":"2026090204122788700_iyag183-B51","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1101\/gad.4.9.1573","article-title":"Abda expression in Drosophila embryos","volume":"4","author":"Karch","year":"1990","journal-title":"Genes Dev"},{"key":"2026090204122788700_iyag183-B52","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1534\/genetics.115.185116","article-title":"Polycomb and trithorax group genes in Drosophila","volume":"206","author":"Kassis","year":"2017","journal-title":"Genetics"},{"key":"2026090204122788700_iyag183-B53","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0065-2660(08)60029-2","article-title":"Molecular and genetic organization of the antennapedia gene complex of Drosophila melanogaster","volume":"27","author":"Kaufman","year":"1990","journal-title":"Adv Genet"},{"key":"2026090204122788700_iyag183-B54","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.molcel.2022.12.032","article-title":"Deciphering the multi-scale, quantitative cis-regulatory code","volume":"83","author":"Kim","year":"2023","journal-title":"Mol Cell"},{"key":"2026090204122788700_iyag183-B55","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/wdev.25","article-title":"Anterior-posterior patterning in early development: three strategies","volume":"1","author":"Kimelman","year":"2012","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"2026090204122788700_iyag183-B56","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-biochem-120219-103641","article-title":"Dynamic competition of Polycomb and Trithorax in transcriptional programming","volume":"89","author":"Kuroda","year":"2020","journal-title":"Annu Rev Biochem"},{"key":"2026090204122788700_iyag183-B57","doi-asserted-by":"publisher","first-page":"dmm049650","DOI":"10.1242\/dmm.049650","article-title":"Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila","volume":"15","author":"Li","year":"2022","journal-title":"Dis Model Mech"},{"key":"2026090204122788700_iyag183-B58","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.molcel.2023.03.011","article-title":"GAGA-associated factor fosters loop formation in the Drosophila genome","volume":"83","author":"Li","year":"2023","journal-title":"Mol Cell"},{"key":"2026090204122788700_iyag183-B59","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2026090204122788700_iyag183-B60","doi-asserted-by":"publisher","first-page":"e2322066121","DOI":"10.1073\/pnas.2322066121","article-title":"Wnt\/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression","volume":"121","author":"Liu","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090204122788700_iyag183-B61","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026090204122788700_iyag183-B62","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1242\/dev.110.4.1197","article-title":"Expression and regulation of the abd-A gene of Drosophila","volume":"110","author":"Macias","year":"1990","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B63","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1242\/dev.02323","article-title":"The ABC of the BX-C: the bithorax complex explained","volume":"133","author":"Maeda","year":"2006","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0070-2153(09)88001-0","article-title":"The bithorax complex of Drosophila an exceptional Hox cluster","volume":"88","author":"Maeda","year":"2009","journal-title":"Curr Top Dev Biol"},{"key":"2026090204122788700_iyag183-B65","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00412-015-0522-0","article-title":"The open for business model of the bithorax complex in Drosophila","volume":"124","author":"Maeda","year":"2015","journal-title":"Chromosoma"},{"key":"2026090204122788700_iyag183-B66","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1242\/dev.00587","article-title":"Differential expression of the Drosophila BX-C in polytene chromosomes in cells of larval fat bodies: a cytological approach to identifying in vivo targets of the homeotic Ubx, Abd-A and Abd-B proteins","volume":"130","author":"Marchetti","year":"2003","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B67","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1203\/00006450-199710000-00001","article-title":"Homeobox genes in embryogenesis and pathogenesis","volume":"42","author":"Mark","year":"1997","journal-title":"Pediatr Res"},{"key":"2026090204122788700_iyag183-B68","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1534\/genetics.119.301292","article-title":"The physical mechanisms of Drosophila gastrulation: mesoderm and endoderm invagination","volume":"214","author":"Martin","year":"2020","journal-title":"Genetics"},{"key":"2026090204122788700_iyag183-B69","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature07522","article-title":"Pulsed contractions of an actin-myosin network drive apical constriction","volume":"457","author":"Martin","year":"2009","journal-title":"Nature"},{"key":"2026090204122788700_iyag183-B70","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0925-4773(03)00046-7","article-title":"Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes","volume":"120","author":"Mishra","year":"2003","journal-title":"Mech Dev"},{"key":"2026090204122788700_iyag183-B71","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1534\/genetics.118.300770","article-title":"Seven-up is a novel regulator of insulin signaling","volume":"208","author":"Musselman","year":"2018","journal-title":"Genetics"},{"key":"2026090204122788700_iyag183-B72","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.mod.2016.12.003","article-title":"Piragua encodes a zinc finger protein required for development in Drosophila","volume":"144","author":"Nazario-Yepiz","year":"2017","journal-title":"Mech Dev"},{"key":"2026090204122788700_iyag183-B73","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/embor.2011.159","article-title":"Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye","volume":"12","author":"Olson","year":"2011","journal-title":"EMBO Rep"},{"key":"2026090204122788700_iyag183-B74","doi-asserted-by":"publisher","first-page":"iyac022","DOI":"10.1093\/genetics\/iyad211","article-title":"FlyBase: updates to the Drosophila genes and genomes database","volume":"227","author":"\u00d6zt\u00fcrk-\u00c7olak","year":"2024","journal-title":"GENETICS"},{"key":"2026090204122788700_iyag183-B75","doi-asserted-by":"publisher","first-page":"786129","DOI":"10.3389\/fcell.2021.786129","article-title":"Origin and development of the adipose tissue, a key organ in physiology and disease","volume":"9","author":"Parra-Peralbo","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026090204122788700_iyag183-B76","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nrg1726","article-title":"Modulating Hox gene functions during animal body patterning","volume":"6","author":"Pearson","year":"2005","journal-title":"Nat Rev Genet"},{"key":"2026090204122788700_iyag183-B77","doi-asserted-by":"publisher","first-page":"9715","DOI":"10.1073\/pnas.0803697105","article-title":"Tools for neuroanatomy and neurogenetics in Drosophila","volume":"105","author":"Pfeiffer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090204122788700_iyag183-B78","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.1242\/dev.129.19.4509","article-title":"Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling","volume":"129","author":"Ponzielli","year":"2002","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B79","doi-asserted-by":"publisher","first-page":"e1007702","DOI":"10.1371\/journal.pgen.1007702","article-title":"Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila bithorax complex","volume":"14","author":"Postika","year":"2018","journal-title":"PLoS Genet"},{"key":"2026090204122788700_iyag183-B80","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/35051615","article-title":"The protein-protein interaction map of Helicobacter pylori","volume":"409","author":"Rain","year":"2001","journal-title":"Nature"},{"key":"2026090204122788700_iyag183-B81","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1073\/pnas.1520926113","article-title":"Combgap contributes to recruitment of Polycomb group proteins in Drosophila","volume":"113","author":"Ray","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090204122788700_iyag183-B82","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/nmeth.1748","article-title":"Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping","volume":"8","author":"Reece-Hoyes","year":"2011","journal-title":"Nat Methods"},{"key":"2026090204122788700_iyag183-B83","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ymeth.2012.07.027","article-title":"Yeast one-hybrid assays: a historical and technical perspective","volume":"57","author":"Reece-Hoyes","year":"2012","journal-title":"Methods"},{"key":"2026090204122788700_iyag183-B84","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1242\/dev.111.2.437","article-title":"Control of the expression of the bithorax complex genes abdominal-A and abdominal-B by cis-regulatory regions in Drosophila embryos","volume":"111","author":"Sanchez-Herrero","year":"1991","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B85","doi-asserted-by":"publisher","first-page":"203722","DOI":"10.1016\/j.cdev.2021.203722","article-title":"The early Drosophila embryo as a model system for quantitative biology","volume":"168","author":"Saunders","year":"2021","journal-title":"Cells Dev"},{"key":"2026090204122788700_iyag183-B86","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cell.2017.08.002","article-title":"Genome regulation by Polycomb and Trithorax: 70 years and counting","volume":"171","author":"Schuettengruber","year":"2017","journal-title":"Cell"},{"key":"2026090204122788700_iyag183-B87","doi-asserted-by":"publisher","first-page":"dev172098","DOI":"10.1242\/dev.172098","article-title":"Assembling the adipose organ: adipocyte lineage segregation and adipogenesis in vivo","volume":"146","author":"Sebo","year":"2019","journal-title":"Development"},{"key":"2026090204122788700_iyag183-B88","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.1171468","article-title":"Epigenetic temporal control of mouse Hox genes in vivo","volume":"324","author":"Soshnikova","year":"2009","journal-title":"Science"},{"key":"2026090204122788700_iyag183-B89","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.ydbio.2011.07.028","article-title":"Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs","volume":"359","author":"Starr","year":"2011","journal-title":"Dev Biol"},{"key":"2026090204122788700_iyag183-B90","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1673-8527(08)60059-4","article-title":"Epigenetic regulation of genes during development: a conserved theme from flies to mammals","volume":"35","author":"Vasanthi","year":"2008","journal-title":"J Genet Genomics"},{"key":"2026090204122788700_iyag183-B91","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1242\/bio.20122915","article-title":"Homeotic functions of the Teashirt transcription factor during adult Drosophila development","volume":"2","author":"Wang","year":"2013","journal-title":"Biol Open"},{"key":"2026090204122788700_iyag183-B92","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1002\/j.1460-2075.1985.tb03889.x","article-title":"Distribution of ultrabithorax proteins in Drosophila","volume":"4","author":"White","year":"1985","journal-title":"EMBO J"},{"key":"2026090204122788700_iyag183-B93","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1261\/rna.032052.111","article-title":"RNASTAR: an RNA STructural alignment repository that provides insight into the evolution of natural and artificial RNAs","volume":"18","author":"Widmann","year":"2012","journal-title":"RNA"},{"key":"2026090204122788700_iyag183-B94","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0022-2836(02)01009-4","article-title":"Prediction, assessment and validation of protein interaction maps in bacteria","volume":"323","author":"Wojcik","year":"2002","journal-title":"J Mol Biol"},{"key":"2026090204122788700_iyag183-B95","doi-asserted-by":"publisher","first-page":"E7469","DOI":"10.1073\/pnas.1621048114","article-title":"Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids","volume":"114","author":"Zhang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090204122788700_iyag183-B96","doi-asserted-by":"publisher","first-page":"10717","DOI":"10.1073\/pnas.91.22.10717","article-title":"The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila","volume":"91","author":"Zollman","year":"1994","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyag183\/69004385\/iyag183.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/234\/1\/iyag183\/69004385\/iyag183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/article-pdf\/234\/1\/iyag183\/69004385\/iyag183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:14:05Z","timestamp":1788336845000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/article\/doi\/10.1093\/genetics\/iyag183\/8735619"}},"subtitle":[],"editor":[{"given":"H","family":"Jafar-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,7,16]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyag183","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,7,16]]},"article-number":"iyag183"}}