{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:04:21Z","timestamp":1789610661895,"version":"build-2803163510"},"reference-count":118,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stem cell quiescence is a reversible state in which cells temporarily exit the cell cycle but remain poised to re-enter on cue. Robust protection of the balance between stem cell quiescence and proliferation (Q-&amp;gt;P) is critical for long-term tissue health. Proliferation without proper resources drives disease states including cancer or birth defects. Conversely, extended periods of quiescence can lead to irreversible senescence, causing stem cell loss, aging symptoms, and vulnerability to oncogenic transformation. Diet is a central regulator of Q-&amp;gt;P. Tissue stem cells are particularly impacted, entering periods of quiescence during nutrient restriction, with rapid induction of proliferation upon feeding. We demonstrated previously that the Hedgehog (Hh) signaling pathway is necessary and sufficient for controlling Q-&amp;gt;P responses to dietary changes in epithelial follicle stem cells (FSCs) in the fly ovary. The Hh effector, cubitus interruptus (Ci), is a transcriptional regulator that mediates the feeding response. To identify Q-&amp;gt;P regulators induced upon Hh signaling, we labeled transcripts that are induced in FSCs during the 6-h Q-&amp;gt;P timecourse using thiouracil tagging (TU-tagging), and sequenced TU-tagged transcripts vs total input to prioritize candidates. Unexpectedly, cell cycle regulators were not induced, suggesting that other mechanisms control Q-&amp;gt;P in FSCs. We describe a sequential screening approach that uncovered 7 novel, feeding-dependent Q-&amp;gt;P regulators, including a cholesterol transporter and, surprisingly, glial and neuronal regulators. Our results highlight the importance of dynamic regulation of gene expression for translation of dietary signals by stem cells, uncovering new pathways for mechanistic investigation.<\/jats:p>","DOI":"10.1093\/genetics\/iyag231","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:22:04Z","timestamp":1787991724000},"source":"Crossref","is-referenced-by-count":0,"title":["Starve-feed cycles direct quiescence to proliferation transitions in\n                    <i>Drosophila<\/i>\n                    follicle stem cells via transcriptional regulation"],"prefix":"10.1093","author":[{"given":"Eric H","family":"Lee","sequence":"first","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline C","family":"Simonet","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zinshteyn","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Fu","sequence":"additional","affiliation":[{"name":"Van Andel Institute , Grand Rapids, MI 49503 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Ananth","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine","family":"Wingle","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony R","family":"Dyson","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan D","family":"Russell","sequence":"additional","affiliation":[{"name":"University of Maryland , College Park, MD 20742 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruthie M","family":"Njagi","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2805-1968","authenticated-orcid":false,"given":"Gabrielle N","family":"Stills","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiya","family":"Ringgold","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminah","family":"Johnson","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arslie","family":"Louis-Jacques","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6573-237X","authenticated-orcid":false,"given":"Gabriel","family":"Vaughn","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Saurman","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara M","family":"Ruiz-Whalen","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer I","family":"Alexander","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Biostatistics and Bioinformatics Core Facility , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-8623","authenticated-orcid":false,"given":"Alana M","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Program in Cancer Signaling and Microenvironment , Philadelphia, PA 19111 ,","place":["United States"]},{"name":"Fox Chase Cancer Center, Immersion Science Program , Philadelphia, PA 19111 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"2026091621414677000_iyag231-B1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/wdev.48","article-title":"Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond","volume":"1","author":"Ables","year":"2012","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"2026091621414677000_iyag231-B2","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1534\/genetics.119.300238","article-title":"Biology of the Caenorhabditis elegans germline stem cell system","volume":"213","author":"Albert Hubbard","year":"2019","journal-title":"Genetics"},{"key":"2026091621414677000_iyag231-B3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"key":"2026091621414677000_iyag231-B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005004","article-title":"Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner","volume":"16","author":"Ameku","year":"2018","journal-title":"PLoS Biol."},{"key":"2026091621414677000_iyag231-B5","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.15252\/embj.201387500","article-title":"Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo","volume":"33","author":"Amoyel","year":"2014","journal-title":"Embo J"},{"key":"2026091621414677000_iyag231-B6","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"2026091621414677000_iyag231-B7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2026091621414677000_iyag231-B8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.gde.2007.05.005","article-title":"Patterning signals and proliferation in Drosophila imaginal discs","volume":"17","author":"Baker","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"2026091621414677000_iyag231-B9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.stem.2017.10.003","article-title":"Long-range GABAergic inputs regulate neural stem cell quiescence and control adult hippocampal neurogenesis","volume":"21","author":"Bao","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Methodol"},{"key":"2026091621414677000_iyag231-B11","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1242\/jeb.016451","article-title":"A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis","volume":"211","author":"Bharucha","year":"2008","journal-title":"J Exp Biol"},{"key":"2026091621414677000_iyag231-B12","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.1242\/dev.055871","article-title":"Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling","volume":"137","author":"Biehs","year":"2010","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B13","doi-asserted-by":"publisher","DOI":"10.3390\/foods13131960","article-title":"Intermittent fasting: myths, fakes and truth on this dietary regimen approach","volume":"13","author":"Brogi","year":"2024","journal-title":"Foods"},{"key":"2026091621414677000_iyag231-B14","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1093\/hmg\/ddx118","article-title":"Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease","volume":"26","author":"Canterini","year":"2017","journal-title":"Hum Mol Genet."},{"key":"2026091621414677000_iyag231-B15","doi-asserted-by":"publisher","first-page":"E1734","DOI":"10.1073\/pnas.1300725110","article-title":"Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis","volume":"110","author":"Chang","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026091621414677000_iyag231-B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2411987121","article-title":"Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone","volume":"121","author":"Chen","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091621414677000_iyag231-B17","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.stemcr.2019.05.012","article-title":"Mechanisms, hallmarks, and implications of stem cell quiescence","volume":"12","author":"Cho","year":"2019","journal-title":"Stem Cell Reports"},{"key":"2026091621414677000_iyag231-B18","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1146\/annurev-biochem-062917-012341","article-title":"Defining adult stem cells by function, not by phenotype","volume":"87","author":"Clevers","year":"2018","journal-title":"Annu Rev Biochem."},{"key":"2026091621414677000_iyag231-B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100592","article-title":"Protocol for evaluating autophagy using LysoTracker staining in the epithelial follicle stem cells of the Drosophila ovary","volume":"2","author":"Correa","year":"2021","journal-title":"STAR Protoc"},{"key":"2026091621414677000_iyag231-B20","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1038\/s41467-017-01322-9","article-title":"Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate","volume":"8","author":"Dai","year":"2017","journal-title":"Nat Commun"},{"key":"2026091621414677000_iyag231-B21","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1038\/emboj.2012.106","article-title":"Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells","volume":"31","author":"de Navascu\u00e9s","year":"2012","journal-title":"EMBO J"},{"key":"2026091621414677000_iyag231-B22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1152\/physrev.00036.2013","article-title":"Glial cells as progenitors and stem cells: new roles in the healthy and diseased brain","volume":"94","author":"Dimou","year":"2014","journal-title":"Physiol Rev"},{"key":"2026091621414677000_iyag231-B23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026091621414677000_iyag231-B24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12915-023-01636-9","article-title":"Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium","volume":"21","author":"Dong","year":"2023","journal-title":"BMC Biol."},{"key":"2026091621414677000_iyag231-B25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.mod.2017.04.002","article-title":"The repertoire of epithelial morphogenesis on display: progressive elaboration of Drosophila egg structure","volume":"148","author":"Duhart","year":"2017","journal-title":"Mech Dev."},{"key":"2026091621414677000_iyag231-B26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/417299a","article-title":"Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E","volume":"417","author":"Duman-Scheel","year":"2002","journal-title":"Nature"},{"key":"2026091621414677000_iyag231-B27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B28","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3389\/fphys.2012.00413","article-title":"From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle","volume":"3","author":"G\u00e9rard","year":"2012","journal-title":"Front Physiol"},{"key":"2026091621414677000_iyag231-B29","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.1073\/pnas.1602779113","article-title":"Dynamic heterogeneity as a strategy of stem cell self-renewal","volume":"113","author":"Greulich","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026091621414677000_iyag231-B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050137","article-title":"Dual lipolytic control of body fat storage and mobilization in Drosophila","volume":"5","author":"Gr\u00f6nke","year":"2007","journal-title":"PLoS Biol"},{"key":"2026091621414677000_iyag231-B31","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.stem.2018.04.003","article-title":"Causes and consequences of hematopoietic stem cell heterogeneity","volume":"22","author":"Haas","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B32","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1083\/jcb.201007142","article-title":"Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation","volume":"191","author":"Hartman","year":"2010","journal-title":"J Cell Biol"},{"key":"2026091621414677000_iyag231-B33","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1534\/genetics.114.173617","article-title":"Novel tools for genetic manipulation of follicle stem cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation","volume":"199","author":"Hartman","year":"2015","journal-title":"Genetics"},{"key":"2026091621414677000_iyag231-B34","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1083\/jcb.201212094","article-title":"Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release","volume":"201","author":"Hartman","year":"2013","journal-title":"J Cell Biol"},{"key":"2026091621414677000_iyag231-B35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fcell.2020.00019","article-title":"Coordinating proliferation, polarity, and cell fate in the Drosophila female germline","volume":"8","author":"Hinnant","year":"2020","journal-title":"Front Cell Dev Biol."},{"key":"2026091621414677000_iyag231-B118","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1101\/gr.185579.114","article-title":"The release 6 reference sequence of the Drosophila melanogaster genome","volume":"25","author":"Hoskins","year":"2015","journal-title":"Genome Res."},{"key":"2026091621414677000_iyag231-B36","doi-asserted-by":"publisher","first-page":"4480","DOI":"10.1038\/s41598-017-04052-6","article-title":"The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary","volume":"7","author":"Hsu","year":"2017","journal-title":"Sci Rep."},{"key":"2026091621414677000_iyag231-B37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1083\/jcb.201309141","article-title":"Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation","volume":"205","author":"Huang","year":"2014","journal-title":"J Cell Biol"},{"key":"2026091621414677000_iyag231-B38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53103","article-title":"High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila","volume":"9","author":"Huang","year":"2020","journal-title":"Elife"},{"key":"2026091621414677000_iyag231-B39","first-page":"1","volume-title":"Current topics in developmental biology","author":"Ingham","year":"2022"},{"key":"2026091621414677000_iyag231-B40","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/353184a0","article-title":"Role of the Drosophila patched gene in positional signalling","volume":"353","author":"Ingham","year":"1991","journal-title":"Nature"},{"key":"2026091621414677000_iyag231-B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000538","article-title":"A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis","volume":"18","author":"Jevitt","year":"2020","journal-title":"PLoS Biol"},{"key":"2026091621414677000_iyag231-B42","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.stem.2007.10.021","article-title":"Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary","volume":"2","author":"Jin","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12703\/r\/12-5","article-title":"Cell cycle exits and U-turns: quiescence as multiple reversible forms of arrest","volume":"12","author":"Johnson","year":"2023","journal-title":"Fac Rev"},{"key":"2026091621414677000_iyag231-B44","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1434","article-title":"Generalizing moving averages for tiling arrays using combined p-value statistics","volume":"9","author":"Kechris","year":"2010","journal-title":"Stat Appl Genet Mol Biol."},{"key":"2026091621414677000_iyag231-B45","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.devcel.2005.09.013","article-title":"BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary","volume":"9","author":"Kirilly","year":"2005","journal-title":"Dev Cell"},{"key":"2026091621414677000_iyag231-B46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/sj.cr.7310123","article-title":"The Drosophila ovary: an active stem cell community","volume":"17","author":"Kirilly","year":"2007","journal-title":"Cell Res."},{"key":"2026091621414677000_iyag231-B47","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.cell.2009.08.035","article-title":"A neural circuit mechanism integrating motivational state with memory expression in Drosophila","volume":"139","author":"Krashes","year":"2009","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101085","article-title":"Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary","volume":"9","author":"Kronen","year":"2014","journal-title":"PLoS One"},{"key":"2026091621414677000_iyag231-B49","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1242\/dev.050351","article-title":"Specific roles of target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary","volume":"137","author":"LaFever","year":"2010","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41525-023-00365-w","article-title":"Understanding the phenotypic variability in Niemann-Pick disease type C (NPC): a need for precision medicine","volume":"8","author":"Las Heras","year":"2023","journal-title":"NPJ Genom Med."},{"key":"2026091621414677000_iyag231-B51","doi-asserted-by":"publisher","author":"Lee","year":"2020","DOI":"10.1101\/2020.11.07.372664"},{"key":"2026091621414677000_iyag231-B52","doi-asserted-by":"publisher","DOI":"10.1242\/bio.059625","article-title":"Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary","volume":"12","author":"Lee","year":"2023","journal-title":"Biol Open"},{"key":"2026091621414677000_iyag231-B53","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1534\/genetics.167.1.311","article-title":"Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster","volume":"167","author":"Lee","year":"2004","journal-title":"Genetics"},{"key":"2026091621414677000_iyag231-B54","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B55","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026091621414677000_iyag231-B56","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20304","article-title":"Cholesterol activates the G-protein coupled receptor smoothened to promote Hedgehog signaling","volume":"5","author":"Luchetti","year":"2016","journal-title":"eLife"},{"key":"2026091621414677000_iyag231-B57","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.stem.2021.01.017","article-title":"Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation","volume":"28","author":"Machado","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B58","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3390\/ijms25020884","article-title":"The role of intracellular potassium in cell quiescence, proliferation, and death","volume":"25","author":"Marakhova","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026091621414677000_iyag231-B59","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.devcel.2020.09.029","article-title":"Cellular mechanisms and regulation of quiescence","volume":"55","author":"Marescal","year":"2020","journal-title":"Dev Cell"},{"key":"2026091621414677000_iyag231-B60","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1242\/dev.121.11.3797","article-title":"Identification and behavior of epithelial stem cells in the Drosophila ovary","volume":"121","author":"Margolis","year":"1995","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B61","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J"},{"key":"2026091621414677000_iyag231-B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010965","article-title":"Spatial regulation of Drosophila ovarian follicle stem cell division rates and cell cycle transitions","volume":"19","author":"Melamed","year":"2023","journal-title":"PLoS Genet."},{"key":"2026091621414677000_iyag231-B63","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61204","article-title":"Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders","volume":"9","author":"Melamed","year":"2020","journal-title":"Elife"},{"key":"2026091621414677000_iyag231-B64","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nmeth.1329","article-title":"TU-tagging: cell type-specific RNA isolation from intact complex tissues","volume":"6","author":"Miller","year":"2009","journal-title":"Nat Methods"},{"key":"2026091621414677000_iyag231-B65","first-page":"203","volume-title":"Current topics in developmental Biology","author":"Nelson","year":"2019"},{"key":"2026091621414677000_iyag231-B66","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13101084","article-title":"The sterol transporter Npc2c controls intestinal stem cell mitosis and host-microbiome interactions in Drosophila","volume":"13","author":"Neophytou","year":"2023","journal-title":"Metabolites"},{"key":"2026091621414677000_iyag231-B67","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1101\/gad.346973.120","article-title":"Dietary interventions as regulators of stem cell behavior in homeostasis and disease","volume":"35","author":"Novak","year":"2021","journal-title":"Genes Dev"},{"key":"2026091621414677000_iyag231-B68","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.stem.2007.07.009","article-title":"An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement","volume":"1","author":"Nystul","year":"2007","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B69","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1046\/j.1365-2443.1997.d01-284.x","article-title":"Phenotypic analysis of null mutants for DE-cadherin and Armadillo in Drosophila ovaries reveals distinct aspects of their functions in cell adhesion and cytoskeletal organization","volume":"2","author":"Oda","year":"1997","journal-title":"Genes Cells"},{"key":"2026091621414677000_iyag231-B70","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1083\/jcb.200710141","article-title":"Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary","volume":"182","author":"O'Reilly","year":"2008","journal-title":"J Cell Biol"},{"key":"2026091621414677000_iyag231-B71","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/0092-8674(87)90706-9","article-title":"Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila","volume":"48","author":"Patel","year":"1987","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B72","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1242\/dev.118.4.1191","article-title":"A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis","volume":"118","author":"Peifer","year":"1993","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B73","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1002\/1873-3468.13867","article-title":"Restriction point regulation at the crossroads between quiescence and cell proliferation","volume":"594","author":"Pennycook","year":"2020","journal-title":"FEBS Lett."},{"key":"2026091621414677000_iyag231-B74","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/ncb3505","article-title":"Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling","volume":"19","author":"Reilein","year":"2017","journal-title":"Nat Cell Biol"},{"key":"2026091621414677000_iyag231-B75","doi-asserted-by":"publisher","first-page":"E3182","DOI":"10.1073\/pnas.1718646115","article-title":"Division-independent differentiation mandates proliferative competition among stem cells","volume":"115","author":"Reilein","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091621414677000_iyag231-B76","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1242\/dev.124.7.1405","article-title":"Examination of the function of two Kelch proteins generated by stop codon suppression","volume":"124","author":"Robinson","year":"1997","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B77","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cell.2011.02.008","article-title":"Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search","volume":"145","author":"Root","year":"2011","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B78","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0925-4773(98)00157-9","article-title":"Gal4 in the Drosophila female germline","volume":"78","author":"R\u00f8rth","year":"1998","journal-title":"Mech Dev."},{"key":"2026091621414677000_iyag231-B79","doi-asserted-by":"publisher","first-page":"5628","DOI":"10.1038\/s41467-020-19361-0","article-title":"A single-cell atlas and lineage analysis of the adult Drosophila ovary","volume":"11","author":"Rust","year":"2020","journal-title":"Nat Commun."},{"key":"2026091621414677000_iyag231-B80","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cois.2019.11.005","article-title":"Signal transduction in the early Drosophila follicle stem cell lineage","volume":"37","author":"Rust","year":"2020","journal-title":"Curr Opin Insect Sci"},{"key":"2026091621414677000_iyag231-B81","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01103","article-title":"Hedgehog signal and genetic disorders","volume":"10","author":"Sasai","year":"2019","journal-title":"Front Genet"},{"key":"2026091621414677000_iyag231-B82","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s42003-024-05804-7","article-title":"Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling","volume":"7","author":"Schmeisser","year":"2024","journal-title":"Commun Biol"},{"key":"2026091621414677000_iyag231-B83","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev-biochem-052521-040313","article-title":"The inseparable relationship between cholesterol and hedgehog signaling","volume":"92","author":"Siebold","year":"2023","journal-title":"Annu Rev Biochem."},{"key":"2026091621414677000_iyag231-B84","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.devcel.2018.08.008","article-title":"Opposing action of hedgehog and insulin signaling balances proliferation and autophagy to determine follicle stem cell lifespan","volume":"46","author":"Singh","year":"2018","journal-title":"Dev Cell"},{"key":"2026091621414677000_iyag231-B85","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1101\/gr.274340.120","article-title":"A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries","volume":"31","author":"Slaidina","year":"2021","journal-title":"Genome Res"},{"key":"2026091621414677000_iyag231-B86","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/1097-0320(20000801)40:4&lt;280::aid-cyto4&gt;3.0.co;2-7","article-title":"Characteristics of a novel deep red\/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy","volume":"40","author":"Smith","year":"2000","journal-title":"Cytometry"},{"key":"2026091621414677000_iyag231-B87","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","article-title":"Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells","volume":"143","author":"Snippert","year":"2010","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B88","doi-asserted-by":"publisher","first-page":"14813","DOI":"10.1073\/pnas.232389399","article-title":"DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary","volume":"99","author":"Song","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091621414677000_iyag231-B89","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1126\/science.1069871","article-title":"Germline stem cells anchored by adherens junctions in the Drosophila ovary niches","volume":"296","author":"Song","year":"2002","journal-title":"Science"},{"key":"2026091621414677000_iyag231-B90","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30413","article-title":"Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila","volume":"7","author":"Sp\u00e9der","year":"2018","journal-title":"Elife"},{"key":"2026091621414677000_iyag231-B91","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cell.2013.08.062","article-title":"The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit","volume":"155","author":"Spencer","year":"2013","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B92","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1073\/pnas.052556499","article-title":"Molecular identification of the insect adipokinetic hormone receptors","volume":"99","author":"Staubli","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091621414677000_iyag231-B93","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1534\/genetics.118.300839","article-title":"Drosophila glypicans regulate follicle stem cell maintenance and niche competition","volume":"209","author":"Su","year":"2018","journal-title":"Genetics"},{"key":"2026091621414677000_iyag231-B94","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256475","article-title":"Single-cell RNA sequencing identifies eggplant as a regulator of germ cell development in Drosophila","volume":"24","author":"Sun","year":"2023","journal-title":"EMBO Rep."},{"key":"2026091621414677000_iyag231-B95","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1083\/jcb.151.4.891","article-title":"Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis","volume":"151","author":"Tanentzapf","year":"2000","journal-title":"J Cell Biol"},{"key":"2026091621414677000_iyag231-B96","doi-asserted-by":"publisher","first-page":"ENEURO-0181","DOI":"10.1523\/ENEURO.0181-17.2017","article-title":"TU-tagging: a method for identifying layer-enriched neuronal genes in developing mouse visual cortex","volume":"4","author":"Tomorsky","year":"2017","journal-title":"eNeuro"},{"key":"2026091621414677000_iyag231-B97","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cub.2020.12.024","article-title":"Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation","volume":"31","author":"Tu","year":"2021","journal-title":"Curr Biol"},{"key":"2026091621414677000_iyag231-B98","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.tcb.2019.05.002","article-title":"Quiescence: good and bad of stem cell aging","volume":"29","author":"T\u00fcmpel","year":"2019","journal-title":"Trends Cell Biol"},{"key":"2026091621414677000_iyag231-B99","doi-asserted-by":"publisher","DOI":"10.1242\/dev.165084","article-title":"Stem cell quiescence: the challenging path to activation","volume":"148","author":"Urb\u00e1n","year":"2021","journal-title":"Development"},{"key":"2026091621414677000_iyag231-B100","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0094","article-title":"Potassium channels in cell cycle and cell proliferation","volume":"369","author":"Urrego","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026091621414677000_iyag231-B101","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nmeth.4437","article-title":"Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations","volume":"14","author":"van den Brink","year":"2017","journal-title":"Nat Methods"},{"key":"2026091621414677000_iyag231-B102","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.stem.2019.01.001","article-title":"Stem cell quiescence: dynamism, restraint, and cellular idling","volume":"24","author":"van Velthoven","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2026091621414677000_iyag231-B103","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.devcel.2012.09.010","article-title":"Regulation of stem cells by intersecting gradients of long-range niche signals","volume":"23","author":"Vied","year":"2012","journal-title":"Dev Cell."},{"key":"2026091621414677000_iyag231-B104","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/genes9030127","article-title":"Wnt signaling in stem cell maintenance and differentiation in the drosophila germarium","volume":"9","author":"Waghmare","year":"2018","journal-title":"Genes (Basel)"},{"key":"2026091621414677000_iyag231-B105","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14533","article-title":"Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate","volume":"8","author":"Wahlestedt","year":"2017","journal-title":"Nat Commun."},{"key":"2026091621414677000_iyag231-B106","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J Mol Diagn"},{"key":"2026091621414677000_iyag231-B107","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061678","article-title":"Niemann-pick type C2 protein regulates free cholesterol accumulation and influences hepatic stellate cell proliferation and mitochondrial respiration function","volume":"19","author":"Wang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026091621414677000_iyag231-B108","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12983-022-00472-x","article-title":"Tissue dissociation for single-cell and single-nuclei RNA sequencing for low amounts of input material","volume":"19","author":"Wiegleb","year":"2022","journal-title":"Front Zool"},{"key":"2026091621414677000_iyag231-B109","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF00444042","article-title":"Specificity of embryonic lethal mutations in Drosophila analyzed in germ line clones","volume":"195","author":"Wieschaus","year":"1986","journal-title":"Rouxs Arch Dev Biol"},{"key":"2026091621414677000_iyag231-B110","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0896-6273(03)00396-9","article-title":"Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system","volume":"39","author":"Wu","year":"2003","journal-title":"Neuron"},{"key":"2026091621414677000_iyag231-B111","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.cell.2016.02.041","article-title":"Hardwiring stem cell communication through tissue structure","volume":"164","author":"Xin","year":"2016","journal-title":"Cell"},{"key":"2026091621414677000_iyag231-B112","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1186\/s13287-025-04687-7","article-title":"Cholesterol metabolism on stem cell fate determination: a frontier horizon","volume":"16","author":"Xu","year":"2025","journal-title":"Stem Cell Res Ther."},{"key":"2026091621414677000_iyag231-B113","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0378-1119(99)00269-3","article-title":"Organization and transcriptional regulation of Drosophila Na(+), K(+)-ATPase beta subunit genes: Nrv1 and Nrv2","volume":"236","author":"Xu","year":"1999","journal-title":"Gene"},{"key":"2026091621414677000_iyag231-B114","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1038\/s41467-021-25146-w","article-title":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster","volume":"12","author":"Yoshinari","year":"2021","journal-title":"Nat Commun."},{"key":"2026091621414677000_iyag231-B115","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"2026091621414677000_iyag231-B116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000721","article-title":"Dilp-2-mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche","volume":"18","author":"Yuan","year":"2020","journal-title":"PLoS Biol"},{"key":"2026091621414677000_iyag231-B117","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35069099","article-title":"Hedgehog acts as a somatic stem cell factor in the Drosophila ovary","volume":"410","author":"Zhang","year":"2001","journal-title":"Nature"}],"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyag231\/70834038\/iyag231.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyag231\/70834038\/iyag231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:41:52Z","timestamp":1789609312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article\/doi\/10.1093\/genetics\/iyag231\/8772958"}},"subtitle":[],"editor":[{"given":"D","family":"Greenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":118,"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyag231","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"article-number":"iyag231"}}