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The rate of recombination varies substantially across living organisms depending on cis- or trans-acting genetic elements, as seen in many species, including the yeast Saccharomyces cerevisiae. Here, we report on an experimental evolution-based study to better understand the factors shaping this natural variation. Starting with a genetically diverse population of S. cerevisiae, we have carried out recurrent divergent selection on recombination rate using a fluorescence-based sorting approach in 4 independent lineages. After 10 generations, we observed an average response of recombination rate of +28% after positive selection and \u221224% after negative selection, within the interval used for selection. In the adjacent region, however, we observed a weaker response in the opposite direction, and no response in 4 other unlinked genomic regions. Whole-genome sequencing of individuals selected for high recombination revealed mixed outcomes in the 4 independently evolved lineages for high genome-wide recombination rates. However, all 4 lineages showed selection for high recombination locally, with particular haplotypes heavily favored and sequence- or structural variation-based heterozygosity selected against within the selection interval. Overall, this experimental evolution approach provides original and useful insights into the evolvability of the meiotic recombination rate and the associated genetic determinants.<\/jats:p>","DOI":"10.1093\/genetics\/iyag239","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:00:12Z","timestamp":1788465612000},"source":"Crossref","is-referenced-by-count":0,"title":["Response to divergent selection on meiotic recombination in\n                    <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0518-0904","authenticated-orcid":false,"given":"Xavier","family":"Raffoux","sequence":"first","affiliation":[{"name":"INRAE, AgroParisTech, GQE\u2014Le Moulon, Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xanita","family":"Saayman","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, IRCAN, Universit\u00e9 C\u00f4te d\u2019Azur , Nice 06107 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A","family":"Abuelgassim","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, GQE\u2014Le Moulon, Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4049-1985","authenticated-orcid":false,"given":"Thomas","family":"Maret","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, GQE\u2014Le Moulon, Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Venon","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, GQE\u2014Le Moulon, Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Dumas","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, GQE\u2014Le Moulon, Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Tattini","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, IRCAN, Universit\u00e9 C\u00f4te d\u2019Azur , Nice 06107 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-5963","authenticated-orcid":false,"given":"Olivier C","family":"Martin","sequence":"additional","affiliation":[{"name":"CNRS, INRAE, Universit\u00e9 Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Universit\u00e9 Paris-Saclay , Gif-sur-Yvette 91190 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