{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:36:54Z","timestamp":1793162214518,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"NIH NHLBI","award":["F31HL165774"],"award-info":[{"award-number":["F31HL165774"]}]},{"name":"NIH NIGMS","award":["F32GM128252"],"award-info":[{"award-number":["F32GM128252"]}]},{"name":"NIH NIGMS","award":["R35GM157067"],"award-info":[{"award-number":["R35GM157067"]}]},{"name":"NIH NIGMS","award":["R35119455"],"award-info":[{"award-number":["R35119455"]}]},{"name":"NIH NIGMS","award":["R35122535"],"award-info":[{"award-number":["R35122535"]}]},{"name":"NIH NIGMS","award":["R35GM118021"],"award-info":[{"award-number":["R35GM118021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Circadian rhythms, \u223c24-h biological cycles, enable organisms to anticipate rhythmic environmental cycles so they can assign proper day and night functions that align with those cycles. Circadian rhythms are defined by their ability to be reset by external cues, their capacity to continue to oscillate in the absence of those cues, and their capacity to maintain clock speed across a range of ambient temperatures, a property known as temperature compensation. In the Neurospora clock, the White Collar Complex (WCC) drives expression of Frequency (FRQ), which nucleates a complex including FRQ-Interacting RNA Helicase and CK1a that phosphorylates and thereby represses WCC activity. Work to date has suggested that kinases may be involved in temperature compensation and that in Neurospora the primary target of these is FRQ. Here, we investigate the genetic relationship between two clock kinases, Casein Kinase I (CKI) (encoded by ck-1a) and Casein Kinase II (CKII) (encoded by cka), in their regulation of temperature compensation using novel alleles, ck-1aD135G and \u0394cka. A qualitative model supported by biochemical analyses shows that CKI activity on FRQ decreases with increasing temperature, and this decrease is countered by increasing activity of CKII. Quantitative proteomics on FRQ across temperatures shows that the FRQ phosphorylation landscape is dependent on temperature and is altered in temperature compensation mutants. In this phosphorylation-driven model for temperature compensation, key temperature compensation-specific domains on FRQ are phosphorylated by CKI and CKII to regulate period length in response to temperature.<\/jats:p>","DOI":"10.1093\/genetics\/iyag279","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:09:04Z","timestamp":1791436144000},"source":"Crossref","is-referenced-by-count":1,"title":["The case for kinases: a phosphorylation-driven model for circadian temperature compensation in\n                    <i>Neurospora crassa<\/i>"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-7360","authenticated-orcid":false,"given":"Elizabeth-Lauren","family":"Stevenson","sequence":"first","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth , Hanover, NH 03755 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-1818","authenticated-orcid":false,"given":"Christina M","family":"Kelliher","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth , Hanover, NH 03755 ,","place":["United States"]},{"name":"Department of Biology, University of Massachusetts Boston , Boston, MA 02125 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-2887","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth , Hanover, NH 03755 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniyal","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Cornell University , Ithaca, NY 14850 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Cornell University , Ithaca, NY 14850 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-4576","authenticated-orcid":false,"given":"Arminja N","family":"Kettenbach","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth , Hanover, NH 03755 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J","family":"Loros","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth , Hanover, NH 03755 ,","place":["United 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