{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:48:47Z","timestamp":1791661727526,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuronal circuits sustain stable function by self-regulating their gene expression and neurosecretion. Patterns for autocrine feedback by neuropeptides are widespread across nervous systems, but how they contribute to neuronal homeostasis is less well understood. Here, we identify an autocrine homeostatic mechanism in a C. elegans peptidergic hub neuron. FLP-1 neuropeptide release activates the inhibitory receptor DMSR-7 on the AVK hub neurons to self-regulate flp-1 transcription, dense-core vesicle accumulation, and peptide secretion. We show that a parallel PDF-1\/PDFR-1 pathway drives flp-1 expression, establishing a \u201cpush-and-pull\u201d peptidergic feedback on the AVK neurons. AVK\u2019s peptidergic output also depends on the number of FLP-1 peptides encoded in its precursor, revealing a dosage mechanism in behavioral regulation. Moreover, flp-1 expression coordinates transcript levels of additional neuropeptides in AVK. These findings uncover FLP-1 as a self-regulating homeostatic controller within a peptidergic hub neuron and fit a model where precursor-encoded redundancy supports stable yet adaptable circuit states.<\/jats:p>","DOI":"10.1093\/genetics\/iyag281","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:01:16Z","timestamp":1791658876000},"source":"Crossref","is-referenced-by-count":0,"title":["Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergic hub neuron"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-8284","authenticated-orcid":false,"given":"Luca","family":"Golinelli","sequence":"first","affiliation":[{"name":"Animal Physiology and Neurobiology, Department of Biology, University of Leuven (KU Leuven) , Naamsestraat 59, 3000, Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-4360","authenticated-orcid":false,"given":"Isabel","family":"Beets","sequence":"additional","affiliation":[{"name":"Animal Physiology and Neurobiology, Department of Biology, University of Leuven (KU Leuven) , Naamsestraat 59, 3000, Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-3995","authenticated-orcid":false,"given":"Liesbet","family":"Temmerman","sequence":"additional","affiliation":[{"name":"Animal Physiology and Neurobiology, Department of Biology, University of Leuven (KU Leuven) , Naamsestraat 59, 3000, Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"container-title":["GENETICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyag281\/71838513\/iyag281.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article-pdf\/doi\/10.1093\/genetics\/iyag281\/71838513\/iyag281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:01:16Z","timestamp":1791658876000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/genetics\/advance-article\/doi\/10.1093\/genetics\/iyag281\/8907349"}},"subtitle":[],"editor":[{"given":"Xiajing","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/genetics\/iyag281","relation":{},"ISSN":["1943-2631"],"issn-type":[{"value":"1943-2631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"article-number":"iyag281"}}