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In multivariable regression analyses, dependent variables included mobility (Timed Up &amp; Go [TUG]), dual tasking (TUG with a simultaneous subtraction task, that is, TUG-Cog, as well as dual task cost), and balance (Figure-of-eight). The analyses were controlled for age, sex, education, diagnosis (ie, MCI), and comorbidity (stroke, diabetes, and ischemic heart disease). Independent variables included WML volume, and measures of \u03b2-amyloid (abnormal cerebrospinal fluid [CSF] A\u03b242\/40 ratio) and tau pathology (CSF phosphorylated tau [p-tau]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariable regression analyses showed that an increased WML volume was independently associated with decreased mobility, that is, TUG (standardized \u03b2 = 0.247; p &amp;lt; .001). Tau pathology was independently associated with dual tasking both when using the raw data of TUG-Cog (\u03b2 = 0.224; p = .003) and the dual-task cost (\u03b2= \u22120.246; p = .001). Amyloid pathology was associated with decreased balance, that is, Figure-of-eight (\u03b2 = 0.172; p = .028). The independent effects of WML and tau pathology were mainly observed in those with MCI, which was not the case for the effects of amyloid pathology on balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Common brain pathologies have different effects where WML are independently associated with mobility, tau pathology has the strongest effect on dual tasking, and amyloid pathology seems to be independently associated with balance. Although these novel findings need to be confirmed in longitudinal studies, they suggest that different brain pathologies have different effects on mobility, balance, and dual-tasking in older nondemented individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glaa143","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T09:34:28Z","timestamp":1591522468000},"page":"683-691","source":"Crossref","is-referenced-by-count":20,"title":["The Effects of Tau, Amyloid, and White Matter Lesions on Mobility, Dual Tasking, and Balance in Older People"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-6721","authenticated-orcid":false,"given":"Maria H","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine, Lund University, Sweden"},{"name":"Clinical Memory Research Unit, Faculty of Medicine, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro Gujord","family":"Tangen","sequence":"additional","affiliation":[{"name":"Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tonsberg, Norway"},{"name":"Department of Geriatric Medicine, Oslo University Hospital, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Palmqvist","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Faculty of Medicine, Lund University, Sweden"},{"name":"Memory Clinic, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-9874","authenticated-orcid":false,"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology, Department of Clinical Sciences, Lund University, Sweden"},{"name":"Image and Function, Skane University Hospital, Lund, 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