{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:32Z","timestamp":1790263652209,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a nationwide, multicenter, retrospective, observational study in patients \u2265 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1\u2013May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index &amp;lt; 60 were 30.8%, 25.6%, 30.5%, and 21.0%, respectively. The overall case-fatality rate was 46.9% (n: 1301) and increased with age (80\u201384 years: 41.6%; 85\u201390 years: 47.3%; 90\u201394 years: 52.7%; \u226595 years: 54.2%). After analysis, male sex and moderate-to-severe dependence were independently associated with in-hospital mortality; comorbidities were not predictive. At admission, independent risk factors for death were: oxygen saturation &amp;lt; 90%; temperature \u2265 37.8\u00b0C; quick sequential organ failure assessment (qSOFA) score \u2265 2; and unilateral\u2013bilateral infiltrates on chest x-rays. Some analytical findings were independent risk factors for death, including estimated glomerular filtration rate &amp;lt; 45 mL\/min\/1.73 m2; lactate dehydrogenase \u2265 500 U\/L; C-reactive protein \u2265 80 mg\/L; neutrophils \u2265 7.5 \u00d7 103\/\u03bcL; lymphocytes &amp;lt; 0.8 \u00d7 103\/\u03bcL; and monocytes &amp;lt; 0.5 \u00d7 103\/\u03bcL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status\u2014not comorbidities\u2014are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gerona\/glaa243","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T08:30:48Z","timestamp":1603701048000},"page":"e28-e37","source":"Crossref","is-referenced-by-count":104,"title":["Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-9867","authenticated-orcid":false,"given":"Jose-Manuel","family":"Ramos-Rincon","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Miguel Hernandez University of Elche, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Buonaiuto","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, M\u00e1laga Regional University Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ricci","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, M\u00e1laga Regional University Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesica","family":"Mart\u00edn-Carmona","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, M\u00e1laga Regional University Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Paredes-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, 12 de Octubre University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calder\u00f3n-Moreno","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Gregorio Mara\u00f1on University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Rubio-Rivas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Bellvitge University Hospital, L\u2019Hospitalet de Llobregat (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Luis","family":"Beato-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Albacete University Hospital Complex, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arnalich-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, La Paz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Monge-Monge","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Segovia Hospital Complex, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Antonio","family":"Vargas-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Acebes-Repiso","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Miguel Servet, Zaragoza Hospital, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mendez-Bailon","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Clinico San Carlos Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Perales-Fraile","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Infanta Sof\u00eda Hospital, S. 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