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We shall also briefly review our emerging interests in the genetic analysis of what we have called Antigeroid Syndromes. While there has been significant progress in that direction via genetic studies of centenarians, the search for genetic pathways that make individuals unusually resistant or resilient to the ravages of specific geriatric disorders has been comparatively neglected. We refer to these disorders as Unimodal Antigeroid Syndromes. It is our hope that our young colleagues will consider research efforts in that direction.<\/jats:p>","DOI":"10.1093\/gerona\/glaa273","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:07:47Z","timestamp":1607544467000},"page":"253-259","source":"Crossref","is-referenced-by-count":13,"title":["Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue\n                    <i>Antigeroid Syndromes<\/i>\n                    !"],"prefix":"10.1093","volume":"76","author":[{"given":"George M","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuki M","family":"Hisama","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Medicine, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"2021011804350755700_CIT0001","first-page":"5","article-title":"Genetic syndromes in man with potential relevance to the pathobiology of aging","volume":"14","author":"Martin","year":"1978","journal-title":"Birth Defects Orig Artic Ser."},{"key":"2021011804350755700_CIT0002","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.272.5259.258","article-title":"Positional cloning of the Werner\u2019s syndrome gene","volume":"272","author":"Yu","year":"1996","journal-title":"Science."},{"key":"2021011804350755700_CIT0003","doi-asserted-by":"crossref","first-page":"a025882","DOI":"10.1101\/cshperspect.a025882","article-title":"How research on human progeroid and antigeroid syndromes can contribute to the longevity dividend initiative","volume":"6","author":"Hisama","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"key":"2021011804350755700_CIT0004","volume-title":"Age Later: Health Span, Life Span, and the New Science of Longevity.","author":"Barzilai","year":"2020"},{"key":"2021011804350755700_CIT0005","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arr.2016.03.002","article-title":"Werner syndrome: clinical features, pathogenesis and potential therapeutic interventions","volume":"33","author":"Oshima","year":"2017","journal-title":"Ageing Res Rev."},{"key":"2021011804350755700_CIT0006","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5070\/D33K77K911","article-title":"Leg ulcer in Werner syndrome (adult progeria): a case report","volume":"19","author":"Fumo","year":"2013","journal-title":"Dermatol Online J."},{"key":"2021011804350755700_CIT0007","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1447-0594.2012.00913.x","article-title":"Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey","volume":"13","author":"Takemoto","year":"2013","journal-title":"Geriatr Gerontol Int."},{"key":"2021011804350755700_CIT0008","doi-asserted-by":"crossref","first-page":"e59709","DOI":"10.1371\/journal.pone.0059709","article-title":"Spectrum and risk of neoplasia in Werner syndrome: a systematic review","volume":"8","author":"Lauper","year":"2013","journal-title":"PLoS ONE."},{"key":"2021011804350755700_CIT0009","first-page":"13","article-title":"Werner syndrome: a changing pattern of clinical manifestations in Japan (1917\u20132008)","volume":"7","author":"Goto","year":"2013","journal-title":"Biosci Trends."},{"key":"2021011804350755700_CIT0010","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/humu.20337","article-title":"The spectrum of WRN mutations in Werner syndrome patients","volume":"27","author":"Huang","year":"2006","journal-title":"Hum Mutat."},{"key":"2021011804350755700_CIT0011","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00005792-196605000-00001","article-title":"Werner\u2019s syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process","volume":"45","author":"Epstein","year":"1966","journal-title":"Medicine (Baltimore)."},{"key":"2021011804350755700_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4684-7853-2_1","article-title":"On cataract in conjunction with scleroderma. 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